Cardiovascular disease (CVD) remains a leading cause of death in China. Systemic inflammation (SI) is an emerging risk factor in atherosclerotic CVD (ASCVD) and chronic kidney disease (CKD). High-sensitivity C-reactive protein (hsCRP) is increasingly recognised for prognostication. The SPARK-CVD China survey assessed Chinese cardiologists' and nephrologists' awareness and perceptions of SI and hsCRP in patients with both ASCVD and CKD. A nationwide cross-sectional survey was conducted (September to December 2024) across 31 provinces in China mainland among physicians with ≥3 years of clinical experience and managing ≥20 adult patients with both ASCVD and CKD per month. Descriptive and comparative statistics were used. Among 1500 respondents, SI was used more to aid treatment than diagnosis (65.2% vs 45.5%). Although 73.3% viewed SI as a key determinant of cardiovascular events, only 35.2% discussed SI as a risk factor with patients. Non-testers cited no expected impact on decisions (71.3%), lack of guideline direction (44.0%), and limited treatments (37.2%). A knowledge-practice gap for hsCRP was observed: 29.7% identified hsCRP unprompted versus 87.7% when prompted; perceived diagnostic thresholds varied widely. Fewer than 1/4 of ASCVD and/or CKD patients would be prescribed colchicine; barriers included limited experience (55.2%), potential contraindications (54.1%), and side effects (47.1%). Cardiorenal benefits of GLP-1 receptor agonists were widely recognised (97.9%), with 76.5% attributing benefits partly to anti-inflammatory effects. SI is acknowledged but inconsistently operationalised domestically. Targeted professional education, explicit guideline recommendations, and further evidence for risk-stratified, inflammation-guided care may help refine treatment pathways for ASCVD with CKD.
The osteo-odonto keratoprosthesis (OOKP) remains a groundbreaking treatment for end-stage corneal blindness after 50 years, but is surgically complex and unsuitable for certain patients, particularly those without healthy teeth. We developed a novel keratoprosthesis (KPro) comprising spark plasma sintered titania-graphene oxide (TiGO) and a 5-mm PMMA optical cylinder, and evaluated its performance as an alternative to the tooth in the OOKP. The KPro's suitability for implantation was first demonstrated through the preservation of surface integrity, chemical structure, and mechanical strength following ethylene oxide sterilization. Mechanical pull-out tests showed that PMMA adhered more strongly to TiGO than to primate teeth after bonding with dental cement, suggesting that the same cement used in OOKP procedures can be used with TiGO skirts. In addition, in vitro studies confirmed TiGO's biocompatibility, supporting adhesion, proliferation, and viability of human corneal stromal fibroblasts. In a rabbit model of OOKP stage 1 surgery, the TiGO integrated successfully into dermal tissue, showing vascularized connective tissue with positive staining for collagen I and III and CD31. In stage 2 simulation, implantation of fibrovascularized KPro onto the ocular surface, under the nictitating membrane, was uneventful with no evidence of tissue melt, PMMA detachment, or adverse inflammatory response over six months. Immunohistological analysis showed that fibrovascular and immune cell markers in the implanted eyes were highest in the nictitating membrane proximal to the PMMA optical cylinder, decreased toward the distal regions, and were low throughout the host cornea. In conclusion, our TiGO-based KPro offers a promising alternative to OOKP, with advantages including a larger PMMA optical cylinder, less complex surgery, and broader surgical indications.
The Brazilian Health Reform Movement succeeded in enshrining health as a constitutional social right, resulting in the creation of the Unified Health System (Sistema Único de Saúde, or SUS), based on the principles of universality, comprehensive care, equity, and democratized participation of users and workers in system management. However, the SUS faces a process of privatization by private Social Health Organizations (Organizações Sociais de Saúde, or OSS). This article reports part of a study involving researchers, including public mental health service workers. The methodological strategy explored narratives related to episodes of care in workplaces. The results revealed what we termed the 'enterprise-mode,' impacting both workers and the care provided in services managed by OSS. SUS health care workers on the shop floor face the challenge of commercial privatizing forces acting against the foundational principles of democratic management inscribed in the Brazilian Psychiatric Reform law enacted in 2001. A relationship is imposed that corrodes interactions within the team and between the team and service users, attempting to silence those who defend the SUS. However, the narratives also reveal sparks of resistance and insubordination emerging in the daily lives of SUS shop floor workers that can strengthen resistance movements for social health rights.
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RyR2 channels regulate Ca2+ release from the sarcoplasmic reticulum (SR), the Ca storage organelle in cardiac muscle. Altered RyR2 activity is a key factor promoting atrial and ventricular Ca- arrhythmias, but it is unclear how changes in RyR2 open probability underlie a sustained pro- or anti-arrhythmic affect against a background of "autoregulation" whereby SR load adjusts until the RyR2 Ca2+ leak once again balances Ca2+ uptake by SERCA2a. Accordingly, tetracaine, a closed channel blocker that increases RyR2 closed durations, increases SR Ca2+ load and promotes Ca2+ waves in CSQ knockout cells. However, flecainide, an open channel blocker that decreases RyR2 open durations inhibits RyR2 activity with no change in SR Ca2+ load and has a sustained anti-arrhythmic action. In quiescent cells flecainide increases Ca2+ spark frequency and decreases spark mass whereas tetracaine decreases spark frequency but not spark mass. We present a multiscale, dynamic model for SR Ca2+ release and uptake in permeabilised cardiomyocytes using experimentally determined RyR2 gating kinetics and SERCA2a uptake that explains the initiation and termination of Ca2+ sparks and these different actions of open and closed RyR2 block on SR Ca2+ load and Ca2+ spark properties. Spark initiation results from opening of a single RyR2 followed by a regenerative phase of Ca2+ induced activation between RyR2s within the dyad cleft. Termination of spark fluorescence occurs as [Ca2+] in the terminal SR declines, reducing the RyR2 Ca2+ flux and dyad [Ca2+] to a point where RyR2s deactivate. Both RyR2 open and closed block produced similar acute inhibition of Ca2+ release during a spark with a consequent increase in SR load. Acute closed block also decreased spark frequency due to reduced frequency of RyR2 opening. This resulted in a much stronger inhibition of overall spark Ca2+ leak and a larger increase in SR load to achieve a new stead-state.
With the increasingly widespread application of artificial intelligence technology, generative artificial intelligence has become an important tool for people to obtain health information due to its convenience and flexibility in health education or health promotion. However, the readability and accuracy of such AI-generated materials still need to be evaluated. To comprehensively evaluate and compare the quality and readability of health education texts about diabetes generated by different generative artificial intelligence (AI) models. We followed a fixed list of ten questions without modifications, systematically presenting the same inquiries to seven generative AI models and exporting their results into defined forms in the text generation process. Five experts were invited to evaluate the texts based on five criteria. The readability index, a readability formula, was used to evaluate the text's readability. Kendall's coefficient of concordance was employed to assess inter-rater reliability. The linear mixed model was used to compare the differences in five dimensions and readability among the health education texts generated by different AI models. Kimi-K1.5 and Doubao attained the highest overall scores in scientific accuracy, whereas iFlytek Spark-V3.5 received lower scores compared to other models. In terms of practical value and logical clarity, Kimi-K1.5 received the highest scores, while iFlytek Spark-V3.5 scored the lowest. In the dimension of reference basis, Kimi-K1.5 and ERNIE Bot-3.5 received relatively high scores, while iFlytek Spark-V3.5 and Doubao scored lower. In the assessment of text readability, higher R-value scores indicate poorer readability. The health education text generated by Doubao had the highest R-value, while iFlytek Spark-V3.5 had the lowest R-value. Kimi-K1.5 performed better across multiple assessment parameters in the overall evaluation of diabetes-related health education texts created by different generative AI models. Notably, among all the models tested, iFlytek Spark-V3.5 showed the best readability.
Nanosecond-level synchronization of a large number of spark gap switches is one of the challenges in building large-scale linear transformer drivers (LTDs). A method using LTD cavities internally integrated with fiber-optic controlled trigger bricks is proposed to simplify the topology of the trigger system. To verify the feasibility of this trigger method, a two-stage LTD is developed with two fiber-optic controlled trigger bricks. The core component of the trigger brick is a ±80 kV fiber-optic controlled spark gap switch, which integrates a DC bias avalanche photoconductive semiconductor switch and a four-gap field distortion spark gap switch. This switch can be reliably triggered over 3000 shots with a jitter below 3 ns at laser energy below 100 μJ and exhibits no self-discharge. The two-stage LTD is synchronously triggered for 180 shots under a bipolar DC voltage of ±60 kV, generating an output current of ∼240 kA with a jitter of less than 3 ns. The proposed trigger method demonstrates potential for extension to multi-stage LTD modules.
Prior biological knowledge and phenotype information can help identify disease genes from whole genome/exome sequencing studies, but how best to incorporate external knowledge with variant data remains challenging. We developed a machine learning algorithm called RankVar to prioritize causative variants for rare diseases, based on clinical notes and genome/exome sequencing profiles. RankVar uses a random forest classifier trained on ~ 1 million variants from the 1000 Genomes Project with spiked-in pathogenic variants. For testing, we compiled sequencing data and phenotype information from several independent datasets: 260 subjects from the Children's Hospital of Philadelphia (CHOP) with positive genetic diagnosis of various Mendelian diseases, 135 subjects from Birth Defects Biorepository (BDB), as well as 356 and 97 subjects with candidate causal variants for autism spectrum disorders from the Simons Simplex Collection (SSC) and the Simons Foundation Powering Autism Research for Knowledge (SPARK), respectively. RankVar achieves a top 10 variant accuracy of 90.0%, 81.5%, 46.1%, and 76.3% for CHOP, BDB, SSC, and SPARK, respectively, with improved performance over existing approaches. Notably, RankVar successfully identified X-linked and Y-linked disease-causal variants, such as KDM6A (p.N915Kfs5*) and SRY (p.W98X), as the top candidate variants. Moreover, we evaluated RankVar for genomic reinterpretation of 130 unsolved CHOP cases with hearing loss and successfully identified 61 candidate causal variants after manual review. In summary, RankVar performed favorably relative to existing methods in our evaluation, accommodated different genetic models and X/Y chromosome variants, and may provide a useful framework for prioritizing variants in monogenic or oligogenic diseases. We anticipate that RankVar may aid in primary genetic diagnosis, genome reinterpretation of previously unsolved cases, and the discovery of novel disease genes.
Ozone therapy, a clinical application of various ozone forms that is used for its antiseptic techniques, has sparked interest in recent years over its unique antimicrobial and anti-inflammatory properties in the body. Moreover, its ability to work as an antiseptic while avoiding antimicrobial resistance has sparked interest in the dental field as no other antiseptic agent is able to do so. As a triatomic molecule of oxygen (O₃), ozone functions through oxidative mechanisms that disrupt microbial cell walls, inhibit biofilm formation, and modulate host immune responses without contributing to antimicrobial resistance. Types of study reviewed: Peer-reviewed articles published in English, including systematic reviews, meta-analyses, observational studies, narrative reviews, case series, and case reports were included in the article. This narrative review synthesizes current evidence on the mechanisms of ozone as well as the therapeutic efficacy of ozone in clinical applications across multiple dental specialties. Three main delivery modalities (gaseous ozone, ozonated water, and ozonated oils) demonstrate diverse clinical benefits and are discussed in the review. Comparative studies indicate that for some dental applications ozone achieves antimicrobial efficacy comparable to conventional agents such as chlorhexidine gluconate (CHX) while exhibiting reduced cytotoxicity.
Ferroptosis therapy is fundamentally constrained by the robust and adaptive redox homeostasis networks of tumor cells. Notably, 7-dehydrocholesterol (7-DHC) has recently emerged as a formidable, non-canonical metabolic firewall that directly intercepts lipid peroxyl radicals at the plasma membrane, rendering conventional glutathione (GSH)-depleting strategies insufficient. To overcome the dual-layered antioxidant defense, we developed a TME-responsive nanoreactor (TS/GLA@HMION) to orchestrate a synchronized "fuel-spark-breach" lipid peroxidation (LPO) cascade. The nanoreactor was constructed by co-encapsulating TASIN-1 (TS) and γ-linolenic acid (GLA) within hollow mesoporous iron oxide nanoparticles (HMION). Upon TME-triggered disassembly, the released GLA undergoes targeted metabolic incorporation via ACSL1, massively expanding the membrane-localized substrate pool for peroxidation to serve as the required fuel. The iron oxide framework functions as a continuous catalytic engine, driving a sustained Fenton-like reaction to generate abundant •OH as the essential catalytic spark. Meanwhile, TS-mediated inhibition of 7-DHC biosynthesis eliminates the terminal membrane-associated radical scavenging capacity. Coupling 7-DHC blockade with iron-mediated GSH depletion decisively breaches the cellular antioxidant shields. Consequently, the synergy of substrate enrichment, radical generation, and antioxidant disruption transforms restricted oxidative stress into the strong LPO cascade, presenting a potent metabolic redox paradigm for treating refractory malignancies.
The success of high-performance n-type Mg3Sb2 has sparked interest in n-type thermoelectric transport of other AM2X2 compounds. However, only a few such compounds have realized n-type transport so far, and their zT values remain low. Therefore, there is an urgent need to systematically understand the factors limiting their n-type thermoelectric performance. Here, using first-principles calculations, this work systematically investigates the defect chemistry, electronic structure, and thermoelectric properties of three-dimensional (3D) bulk CaMg2Sb2. Calculated results show that the n-type system shows a much higher power factor than the p-type counterpart, reaching 59 µW cm-1 K-1 at 300 K and 39 µW cm-1 K-1 at 725 K, and exhibits a maximum zT of ∼1.52 at 725 K. Defect analysis reveals that Sb-rich conditions favor the formation of Ca vacancies, while Mg-rich and Ca-rich conditions favor the formation of Mg and Ca interstitials, yielding n-type conduction with an electron concentration of 3 × 1016 cm-3 at 725 K. These findings suggest that establishing Mg-rich and Ca-rich growth conditions is one of the key factors for achieving high-performance n-type thermoelectric transport. This study is expected to provide theoretical guidance for achieving high-performance n-type CaMg2Sb2 thermoelectric materials.
The proposed criteria for "terminal anorexia nervosa" (T-AN) by Gaudiani et al. (2022) sparked controversy within the eating disorder (ED) community. This study aimed to explore the perspectives of key stakeholders (individuals with lived experience, caregivers, and ED clinicians) on these criteria, which include: (1) an AN diagnosis, (2) age 30 or older, (3) prior engagement in high-quality treatment, and (4) consistent expression of treatment futility by an individual with decision-making capacity. A mixed-methods design was used, with up to 219 participants completing quantitative Likert-scale items and up to 182 completing qualitative open-ended questions. Data were analyzed using descriptive statistics and thematic analysis. Participants expressed more negative views or disagreement with three of the four criteria, particularly the age requirement (22.4% disagreed, 38.8% strongly disagreed). The fourth criteria received the most agreement (21.6% strongly agree, 25.2% agree). Overarching qualitative themes included ethical concerns; potential for harm; respect for autonomy; challenges in determining prognosis, capacity and futility; treatment issues; and the need for systemic reform over terminal labeling. While most were critical of T-AN, a subset of participants expressed support for elements of the framework, particularly in relation to autonomy and the alleviation of suffering. Overall, the data revealed that many participants engaged with the broader question of whether T-AN should be defined at all, rather than only evaluating the proposed criteria. Instead of a terminal prognosis, more participants advocated for systemic changes. These findings underscore the need for clear, consensus-driven terminology and a focus on patient-centered, ethically grounded care.
The rapid adoption of conversational AI among adolescents has sparked growing debate about its implications for development and well-being. This article applies a Self-Determination Theory lens to explore how and under which conditions adolescents' conversational AI usage supports or frustrates their basic psychological needs for competence, relatedness, and autonomy. Conversational AI may enhance competence through learning assistance, relatedness through emotional and relational support, and autonomy through increased independence. At the same time, it may also promote the risk of superficial competence, displace human relationships, and constrain authentic autonomy. Overall, the role conversational AI plays in adolescents' development is unlikely to be universally positive or negative for all adolescents, but instead depends on how, why, and in which context these technologies are used, highlighting the need for nuanced research and developmentally sensitive design.
Defect engineering offers a practical route to control interfacial charge states in polymer-inorganic composites, yet translating this control into optically writable and non-volatile polarization in soft dielectrics remains difficult. Here, we introduce a Polydimethylsiloxane (PDMS)-based composite that can be written by light to form an interfacial polarization state. The design relies on FeTiO3 (FTO) nanoparticles with oxygen-vacancy associated trap states, whose density is tuned by spark plasma sintering to create a trap-rich polymer-oxide interface. Under illumination, photocarriers promote interfacial charge transfer by reducing the effective barrier at the metal-composite contact, producing a rapid rise in interfacial charge accumulation. After the light is removed, a large fraction of the photoexcited electrons becomes immobilized, leaving a residual polarization that relaxes only slowly. We quantify the write-relax behavior using a triboelectric nanogenerator configuration as a sensitive probe of interfacial charge transfer, and we directly visualize the photo-written electrostatic state and its retention by Kelvin probe force microscopy. These results present defect-mediated charge trapping as a materials-level mechanism for light-programmable, long-retention polarization in soft composites, enabling remotely addressable electrostatic interfaces for soft electronic systems.
The ubiquity of digital media has sparked widespread debate over their potential effects on our cognition, often centred on concerns about declining cognitive capacity. We propose a framework in which digital media use may influence cognition mainly by recalibrating how effort is valued and allocated. Platforms engineered for minimal friction and immediate reward can reinforce habit loops that bias cost-benefit computations, making low-effort digital activities feel more valuable than cognitively demanding tasks such as focused work. Over time, this recalibration of effort valuation may shift effort allocation tendencies towards exploration rather than the sustained exploitation required for mastery and durable knowledge acquisition. We outline an interdisciplinary research agenda that integrates experimental, neurobiological and longitudinal approaches to empirically test this effort recalibration framework and shift the focus from whether digital media harm cognition to whether and how they reshape our willingness to invest effort in everyday life.
Background: As populations age globally, communities are challenged to promote health equity and well-being for older adults. The World Health Organization's (WHO's) Global Network for Age-Friendly Cities and Communities provides a platform for sharing local innovations, while Global Learning for Health Equity (GL4HE) offers a framework for reciprocal, evidence-to-action learning across borders. Objective: This case study examines a bilateral exchange between Athens County, Ohio, USA, and Slovenia to assess how short-term, immersive exchanges can stimulate innovation, clarify contextual factors, and build relationships that support age-friendly practice, following the GL4HE framework. Methods: The project engaged a seven-member delegation from Athens County in Slovenia (January 2025) and a six-member Slovenian delegation in Athens County (May 2025). Delegations included representatives from local government, public health, community organizations, and academia. Itineraries combined structured site visits, informal reflection sessions, and cultural experiences. Documentation included agendas, minutes, reflections, evaluation, and message logs. Data were analyzed using a hybrid coding approach informed by the GL4HE framework and WHO Age-Friendly domains, with inductive coding to identify emergent themes. Results: Five themes emerged: (1) inspiration sparks innovation, (2) comparative learning clarified context, (3) time for focus, (4) group reflection enhances learning, and (5) exchanges build relationships that inspire future collaboration. Participants reported both professional and personal transformation, with recognition that exchanges at the "explore" stage of GL4HE generate inspiration more than direct adoption. Conclusions: Short-term exchanges are valuable vehicles for advancing age-friendly practice through global learning. By prioritizing a concentrated focus on a single issue (e.g., aging), reflection, and relationship building, exchanges provide a foundation for reciprocity and evidence-to-action transfer. Even without immediate adoption, such experiences can catalyze equity-oriented innovation and strengthen the relational infrastructure needed for sustained collaboration.
The application of natural plant-based medicine has sparked a great interest in Fagonia cretica, a traditional herb with medicinal properties. However comprehensive evidence regarding anti-inflammatory mechanism remains limited. This study aimed to evaluate phytochemical, anti-inflammatory and toxicological profiles of Fagonia cretica ethanolic extract (EEFC). EEFC was prepared by Soxhlet extraction, and bioactive components were identified using GC-MS analysis. According to OECD guidelines, Swiss albino rats were orally administered at different doses in acute and subacute toxicity. GC-MS analysis revealed 30 phytocompounds with Octan-2-yl palmitate, Pyridine-3-carboxamide, and 2-Ethylhexyl stearate present abundantly. In acute and subacute toxicity, EEFC did not induce any toxicity or mortality, as well as no significant change in blood parameters. Bovine serum albumin assay (BSA), EEFC manifested significant concentration-dependent inhibition of protein denaturation at 50,100, 250, 500, and 1000 µg/ml (IC50= 34.79 µg/ml) as compared to the SC group (p < 0.05) (IC50= 22.51 µg/ml). In the COX-1 and COX-2 assays, EEFC has significant inhibitory activity as compared to the standard drug DS. In the carrageenan-induced paw edema model, 100 mg/kg (5.71 ± 0.02), 200 mg/kg (5.26 ± 0.03) and 400 mg/kg (4.46 ± 0.01) reduced paw edema in a dose-dependent manner, showing a biphasic process. Furthermore, following Swiss ADME and toxicity analysis, molecular docking demonstrated strong binding affinities with COX-1 (6Y3C) and COX-2 (5KIR), with in the range - 7.7 and - 8.0, respectively. In conclusion, EEFC exhibited significant anti-inflammatory activity and demonstrated favorable preclinical safety profile.
Biological food contamination is a serious public health and economic problem worldwide. Antibiotics are commonly used to address this issue, but rising bacterial resistance has sparked interest in natural alternatives, such as carvacrol. Carvacrol (CAR), a bioactive compound in oregano and thyme essential oils, has demonstrated potent antimicrobial properties. However, its high volatility and environmental sensitivity limit direct application in food systems, requiring encapsulation strategies to enhance stability and controlled release. This study aimed to develop and characterize polyhydroxybutyrate nanoparticles (CAR-PHB-NPs) encapsulating carvacrol for enhanced stability, antimicrobial activity, and controlled release behavior. Nanoparticles were synthesized via nanoprecipitation, yielding hydrodynamic diameters of 200-250 nm, polydispersity index values of 0.220-0.327, and zeta potential values of -25 to -43 mV, ensuring colloidal stability. Storage tests confirmed refrigeration-maintained nanoparticle stability for over 247 days. Among the tested formulations, 25%CAR-0.2%PHB-NPs exhibited the highest encapsulation efficiency (15.56%). Release kinetics studies demonstrated prolonged release, particularly in non-polar solvent systems simulating moderate and lipid-rich matrices. The antimicrobial activity of CAR-PHB-NPs was confirmed against Staphylococcus aureus and Listeria monocytogenes, with inhibitory effects of 0.76 log (CFU/mL) and 0.56 log (CFU/mL), respectively. Additionally, cytotoxic assay in A549 human lung epithelial cells revealed a dose-dependent reduction in cell viability, moderate concentrations maintaining viability above 50%, suggesting balance between biocompatibility and functional anticancer activity. Overall, CAR-PHB-NPs demonstrated a promising role in food preservation and biomedical applications by ensuring sustained antimicrobial activity and controlled cytotoxic effects. Future research should optimize formulations, assess gastrointestinal absorption mechanisms, and explore targeted drug delivery applications.
In this study, a trace amount of boron was added to the NbTaTi1.5V RHEA to enhance its strength. Specifically, (NbTaTi1.5V)100-xBx alloys with varying boron contents were fabricated by ball milling and spark plasma sintering (SPS). With the addition of 1 at.% boron, the compressive fracture strength of the alloy increased by 21.3% relative to the B0 alloy, rising from 2975 to 3610 MPa. A compressive fracture strain of 14.8% was maintained. The microhardness increased from 881 ± 67 HV to 1060 ± 60 HV, corresponding to an improvement of 20.4%. The microstructure analysis indicated that the (NbTaTi1.5V)100-xBx alloys were composed of three fine-grained phases, namely BCC phase, TiO phase and TiB phase. The addition of trace amounts of boron led to significant grain refinement, resulting in a uniform and refined microstructure in the sintered alloys. The average grain size of B1 alloy was only 0.91 µm, representing a 67% reduction compared with that of the B0 alloy (2.82 µm). This provided a favorable microstructural foundation for the synergistic strengthening of the alloys. The boron element contributed 48.2% of the yield strength enhancement in B1 alloy by grain boundary strengthening through grain refinement, which was the dominant strengthening mechanism. TiB and TiO particles promoted dislocation proliferation, resulting in an additional strengthening contribution of approximately 28.7%. Furthermore, the TiB phase enhanced resistance to plastic deformation by impeding dislocation slip through crack deflection. This synergistic multi-mechanism strengthening strategy offers an effective approach for improving the mechanical properties of (NbTaTi1.5V)100-xBx alloys.
The association between periodontal diseases and gastrointestinal conditions, particularly those associated with Helicobacter pylori and systemic inflammation, has garnered increased scientific attention because of its clinical and public health implications. These diseases, which affect both the oral cavity and the digestive system, have shared pathophysiological mechanisms that link inflammatory processes and bacterial transmission pathways. The possible presence of H. pylori in the oral cavity has sparked interest regarding its potential colonization of periodontal tissues and acting as an extragastric reservoir. This narrative review describes H. pylori's possible survival mechanisms in this oral microenvironment and its clinical significance in the interaction between oral and gastric conditions. We propose that periodontitis might promote gastric H. pylori infection by stimulating systemic inflammation, and oral colonization might serve as a reservoir for gastric reinfection. Future studies may involve advanced technologies such as metagenomics and proteomics. The eradication of H. pylori in the oral cavity may provide a strategy to prevent gastric reinfection. The findings described herein highlight the importance of this bacterium in two different pathologies sharing a close anatomical relationship.