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This paper explores the potential opportunities, risks, and challenges associated with the use of large language models (LLMs) in sports science and medicine. LLMs are large neural networks with transformer style architectures trained on vast amounts of textual data, and typically refined with human feedback. LLMs can perform a large range of natural language processing tasks. In sports science and medicine, LLMs have the potential to support and augment the knowledge of sports medicine practitioners, make recommendations for personalised training programs, and potentially distribute high-quality information to practitioners in developing countries. However, there are also potential risks associated with the use and development of LLMs, including biases in the dataset used to create the model, the risk of exposing confidential data, the risk of generating harmful output, and the need to align these models with human preferences through feedback. Further research is needed to fully understand the potential applications of LLMs in sports science and medicine and to ensure that their use is ethical and beneficial to athletes, clients, patients, practitioners, and the general public.

Publication selection bias undermines the systematic accumulation of evidence. To assess the extent of this problem, we survey over 68,000 meta-analyses containing over 700,000 effect size estimates from medicine (67,386/597,699), environmental sciences (199/12,707), psychology (605/23,563), and economics (327/91,421). Our results indicate that meta-analyses in economics are the most severely contaminated by publication selection bias, closely followed by meta-analyses in environmental sciences and psychology, whereas meta-analyses in medicine are contaminated the least. After adjusting for publication selection bias, the median probability of the presence of an effect decreased from 99.9% to 29.7% in economics, from 98.9% to 55.7% in psychology, from 99.8% to 70.7% in environmental sciences, and from 38.0% to 29.7% in medicine. The median absolute effect sizes (in terms of standardized mean differences) decreased from d = 0.20 to d = 0.07 in economics, from d = 0.37 to d = 0.26 in psychology, from d = 0.62 to d = 0.43 in environmental sciences, and from d = 0.24 to d = 0.13 in medicine.

Model Medicine is the science of understanding, diagnosing, treating, and preventing disorders in AI models, grounded in the principle that AI models -- like biological organisms -- have internal structures, dynamic processes, heritable traits, observable symptoms, classifiable conditions, and treatable states. This paper introduces Model Medicine as a research program, bridging the gap between current AI interpretability research (anatomical observation) and the systematic clinical practice that complex AI systems increasingly require. We present five contributions: (1) a discipline taxonomy organizing 15 subdisciplines across four divisions -- Basic Model Sciences, Clinical Model Sciences, Model Public Health, and Model Architectural Medicine; (2) the Four Shell Model (v3.3), a behavioral genetics framework empirically grounded in 720 agents and 24,923 decisions from the Agora-12 program, explaining how model behavior emerges from Core--Shell interaction; (3) Neural MRI (Model Resonance Imaging), a working open-source diagnostic tool mapping five medical neuroimaging modalities to AI interpretability techniques, validated through four clinical cases demonstrating imaging, compari

Objective: Translational science aims at "translating" basic scientific discoveries into clinical applications. The identification of translational science has practicality such as evaluating the effectiveness of investments made into large programs like the Clinical and Translational Science Awards. Despite several proposed methods that group publications---the primary unit of research output---into some categories, we still lack a quantitative way to place papers onto the full, continuous spectrum from basic research to clinical medicine. Methods: Here we learn vector-representations of controlled vocabularies assigned to MEDLINE papers to obtain a Translational Axis (TA) that points from basic science to clinical medicine. The projected position of a term on the TA, expressed by a continuous quantity, indicates the term's "appliedness." The position of a paper, determined by the average location over its terms, quantifies the degree of its "appliedness," which we term as "level score." Results: We validate our method by comparing with previous techniques, showing excellent agreement yet uncovering significant variations of scores of papers in previously defined categories. The m

Introduction. Clinical and Translational Science Award (CTSA) programs must document their scholars' research impact, but assembling each scholar's record by hand takes staff an estimated 15 hours and does not scale to a full cohort. An artificial intelligence (AI) agent could serve as a tool to gather scholar data across platforms and disciplines. Methods. We built a human-in-the-loop AI agent that assembles a dossier of sourced evidence for each scholar and drafts one-sentence Translational Science Benefits Model (TSBM) impact summaries for staff review. We evaluated it in the impact-reporting workflow of one CTSA hub across 10 career-development (KL2/K12) scholars. Two evaluation staff independently coded all 507 findings as accept, edit, or reject; the primary measure was the unanimous usable rate, defined as the share both accepted or edited. Results. Both reviewers accepted or edited 81.7% of the agent's findings. Reviewers each spent a median of 14 minutes per scholar, replacing an estimated 15 hours of manual assembly. Inter-rater agreement was moderate (Cohen's kappa 0.43 on the usable-versus-reject decision). A profile discovery study found the agent's recall close to hum

The large instantaneous sensitivity, a wide frequency coverage and flexible observation modes with large number of beams in the sky are the main features of the SKA observatory's two telescopes, the SKA-Low and the SKA-Mid, which are located on two different continents. Owing to these capabilities, the SKAO telescopes are going to be a game-changer for radio astronomy in general and pulsar astronomy in particular. The eleven articles in this special issue on pulsar science with the SKA Observatory describe its impact on different areas of pulsar science. In this lead article, a brief description of the two telescopes highlighting the relevant features for pulsar science is presented followed by an overview of each accompanying article, exploring the inter-relationship between different pulsar science use cases.

Mauve is a low-cost small satellite developed and operated by Blue Skies Space Ltd. The payload features a 13 cm telescope connected with a fibre that feeds into a UV-Vis spectrometer. The detector covers the 200-700 nm range in a single shot, obtaining low resolution spectra at R~20-65. Mauve has launched on 28th November 2025, reaching a 510 km Low-Earth Sun-synchronous orbit. The satellite will enable UV and visible observations of a variety of stellar objects in our Galaxy, filling the gaps in the ultraviolet space-based data. The researchers that have already joined the mission have defined the science themes, observational strategy and targets that Mauve will observe in the first year of operations. To date 10 science themes have been developed by the Mauve science collaboration for year 1, with observational strategies that include both long duration monitoring and short cadence snapshots. Here, we describe these themes and the science that Mauve will undertake in its first year of operations.

Scientific and technological advances in medicine and systems biology have unequivocally shown that health and disease must be viewed in the context of the interplay among multiple molecular and environmental factors. Understanding the effects of cellular interconnection on disease progression may lead to the identification of novel disease genes and pathways, and hence influence precision diagnostics and therapeutics. To accomplish this goal, the emerging field of network medicine applies network science approaches to investigate disease pathogenesis, integrating information from relevant Omics databases, including protein-protein interaction, correlation-based, gene regulatory, and Bayesian networks. However, this requires analysing and computing large amounts of data. Moreover, if we are to efficiently search for new drugs and new drug combinations, there is a pressing need for computational methods that could allow us to access the immense chemical compound space until now largely unexplored. Finally, at the microscopic level, drug-target chemistry simulation is ultimately a quantum problem, and hence it requires a quantum solution. As we will discuss, quantum computing may be

GREX-PLUS (Galaxy Reionization EXplorer and PLanetary Universe Spectrometer) is a mission candidate for a JAXA strategic L-class mission to be launched in the 2030s. Its primary science goals are two-fold: galaxy formation and evolution, and planetary system formation and evolution. The GREX-PLUS spacecraft will carry a telescope with a 1 m primary mirror aperture cooled down to 50 K. The two science instruments will be onboard: a wide-field camera in the 2--8 $μ$m wavelength band and a high-resolution spectrometer with a wavelength resolution of 30,000 in the 10--18 $μ$m band. The GREX-PLUS wide-field camera aims to detect the first generation of galaxies at redshift $z>15$. The GREX-PLUS high-resolution spectrometer aims to identify the location of the water ``snowline'' in protoplanetary disks. Both instruments will provide unique datasets for a broad range of scientific topics, including galaxy mass assembly, the origin of supermassive blackholes, infrared background radiation, molecular spectroscopy in the interstellar medium, transit spectroscopy of exoplanet atmospheres, planetary atmospheres in the Solar System, and so on. This document is the second version of a collect

Access to Kurdish medicine brochures is limited, depriving Kurdish-speaking communities of critical health information. To address this problem, we developed a specialized Machine Translation (MT) model to translate English medicine brochures into Sorani Kurdish using a parallel corpus of 22,940 aligned sentence pairs from 319 brochures, sourced from two pharmaceutical companies in the Kurdistan Region of Iraq (KRI). We trained a Statistical Machine Translation (SMT) model using the Moses toolkit, conducting seven experiments that resulted in BLEU scores ranging from 22.65 to 48.93. We translated three new brochures to improve the evaluation process and encountered unknown words. We addressed unknown words through post-processing with a medical dictionary, resulting in BLEU scores of 56.87, 31.05, and 40.01. Human evaluation by native Kurdish-speaking pharmacists, physicians, and medicine users showed that 50% of professionals found the translations consistent, while 83.3% rated them accurate. Among users, 66.7% considered the translations clear and felt confident using the medications.

A unified mathematical language for medicine and science will be presented. Using this language, models for DNA replication, protein synthesis, chemical reactions, neurons and a cardiac cycle of a heart have been built. Models for Turing machines, cellular automaton, fractals and physical systems are also represented with the use of this language. Interestingly, the language comes with a way to represent probability theory concepts and also programming statements. With this language, questions and processes in medicine can be represented as systems of equations; and solutions to these equations are viewed as treatments or previously unknown processes. This language can serve as the framework for the creation of a large interactive open-access scientific database that allows extensive mathematical medicine computations. It can also serve as a basis for exploring ideas related to what could be called metascience.

AI for Science (AI4Science), particularly in the form of self-driving labs, has the potential to sideline human involvement and hinder scientific discovery within the broader community. While prior research has focused on ensuring the responsible deployment of AI applications, enhancing security, and ensuring interpretability, we also propose that promoting openness in AI4Science discoveries should be carefully considered. In this paper, we introduce the concept of AI for Open Science (AI4OS) as a multi-agent extension of AI4Science with the core principle of maximizing open knowledge translation throughout the scientific enterprise rather than a single organizational unit. We use the established principles of Knowledge Discovery and Data Mining (KDD) to formalize a language around AI4OS. We then discuss three principle stages of knowledge translation embedded in AI4Science systems and detail specific points where openness can be applied to yield an AI4OS alternative. Lastly, we formulate a theoretical metric to assess AI4OS with a supporting ethical argument highlighting its importance. Our goal is that by drawing attention to AI4OS we can ensure the natural consequence of AI4Scie

The last few years have seen rapid progress in transitioning quantum computing from lab to industry. In healthcare and life sciences, more than 40 proof-of-concept experiments and studies have been conducted; an increasing number of these are even run on real quantum hardware. Major investments have been made with hundreds of millions of dollars already allocated towards quantum applications and hardware in medicine. In addition to pharmaceutical and life sciences uses, clinical and medical applications are now increasingly coming into the picture. This chapter focuses on three key use case areas associated with (precision) medicine, including genomics and clinical research, diagnostics, and treatments and interventions. Examples of organizations and the use cases they have been researching are given; ideas how the development of practical quantum computing applications can be further accelerated are described.

Objective: To (1) demonstrate the implementation of a data science platform built on open-source technology within a large, academic healthcare system and (2) describe two computational healthcare applications built on such a platform. Materials and Methods: A data science platform based on several open source technologies was deployed to support real-time, big data workloads. Data acquisition workflows for Apache Storm and NiFi were developed in Java and Python to capture patient monitoring and laboratory data for downstream analytics. Results: The use of emerging data management approaches along with open-source technologies such as Hadoop can be used to create integrated data lakes to store large, real-time data sets. This infrastructure also provides a robust analytics platform where healthcare and biomedical research data can be analyzed in near real-time for precision medicine and computational healthcare use cases. Discussion: The implementation and use of integrated data science platforms offer organizations the opportunity to combine traditional data sets, including data from the electronic health record, with emerging big data sources, such as continuous patient monitorin

With the increasing interest in deploying Artificial Intelligence in medicine, we previously introduced HAIM (Holistic AI in Medicine), a framework that fuses multimodal data to solve downstream clinical tasks. However, HAIM uses data in a task-agnostic manner and lacks explainability. To address these limitations, we introduce xHAIM (Explainable HAIM), a novel framework leveraging Generative AI to enhance both prediction and explainability through four structured steps: (1) automatically identifying task-relevant patient data across modalities, (2) generating comprehensive patient summaries, (3) using these summaries for improved predictive modeling, and (4) providing clinical explanations by linking predictions to patient-specific medical knowledge. Evaluated on the HAIM-MIMIC-MM dataset, xHAIM improves average AUC from 79.9% to 90.3% across chest pathology and operative tasks. Importantly, xHAIM transforms AI from a black-box predictor into an explainable decision support system, enabling clinicians to interactively trace predictions back to relevant patient data, bridging AI advancements with clinical utility.

Stanford Medicine is building a new data platform for our academic research community to do better clinical data science. Hospitals have a large amount of patient data and researchers have demonstrated the ability to reuse that data and AI approaches to derive novel insights, support patient care, and improve care quality. However, the traditional data warehouse and Honest Broker approaches that are in current use, are not scalable. We are establishing a new secure Big Data platform that aims to reduce time to access and analyze data. In this platform, data is anonymized to preserve patient data privacy and made available preparatory to Institutional Review Board (IRB) submission. Furthermore, the data is standardized such that analysis done at Stanford can be replicated elsewhere using the same analytical code and clinical concepts. Finally, the analytics data warehouse integrates with a secure data science computational facility to support large scale data analytics. The ecosystem is designed to bring the modern data science community to highly sensitive clinical data in a secure and collaborative big data analytics environment with a goal to enable bigger, better and faster scie

Large language models (LLMs) have exhibited exceptional capabilities in natural language understanding and generation, image recognition, and multimodal tasks, charting a course towards AGI and emerging as a central issue in the global technological race. This manuscript conducts a comprehensive review of the core technologies that support LLMs from a user standpoint, including prompt engineering, knowledge-enhanced retrieval augmented generation, fine tuning, pretraining, and tool learning. Additionally, it traces the historical development of Science of Science (SciSci) and presents a forward looking perspective on the potential applications of LLMs within the scientometric domain. Furthermore, it discusses the prospect of an AI agent based model for scientific evaluation, and presents new research fronts detection and knowledge graph building methods with LLMs.

Data science and technology offer transformative tools and methods to science. This review article highlights latest development and progress in the interdisciplinary field of data-driven plasma science (DDPS). A large amount of data and machine learning algorithms go hand in hand. Most plasma data, whether experimental, observational or computational, are generated or collected by machines today. It is now becoming impractical for humans to analyze all the data manually. Therefore, it is imperative to train machines to analyze and interpret (eventually) such data as intelligently as humans but far more efficiently in quantity. Despite the recent impressive progress in applications of data science to plasma science and technology, the emerging field of DDPS is still in its infancy. Fueled by some of the most challenging problems such as fusion energy, plasma processing of materials, and fundamental understanding of the universe through observable plasma phenomena, it is expected that DDPS continues to benefit significantly from the interdisciplinary marriage between plasma science and data science into the foreseeable future.

This article explores citing and referencing systems in Social Sciences and Medicine articles from different theoretical and practical perspectives, considering bibliographic references as a facet of descriptive representation. The analysis of citing and referencing elements (i.e. bibliographic references, mentions, quotations, and respective in-text reference pointers) identified citing and referencing habits within disciplines under consideration and errors occurring over the long term as stated by previous studies now expanded. Future expected trends of information retrieval from bibliographic metadata was gathered by approaching these referencing elements from the FRBR Entities concepts. Reference styles do not fully accomplish with their role of guiding authors and publishers on providing concise and well-structured bibliographic metadata within bibliographic references. Trends on representative description revision suggest a predicted distancing on the ways information is approached by bibliographic references and bibliographic catalogs adopting FRBR concepts, including the description levels adopted by each of them under the perspective of the FRBR Entities concept. This stu