Despite advances in therapy, data on long-term survival and temporal mortality patterns in real-world heart failure (HF) populations, particularly during the critical early period after diagnosis or clinical destabilization, remain scarce. This study aimed to analyze long-term survival and identify factors associated with mortality in a prospective Russian real-world HF cohort that is relatively underrepresented in the international registry literature. A prospective 5-years registry study consecutively enrolled 150 patients with HF in February-May 2018. Participants underwent comprehensive assessment of clinical state, traditional cardiovascular risk factors (RF), psychosocial RF, quality of life, perception of illness, cognitive function, and treatment characteristics. Survival was analyzed using the Kaplan-Meier method, and mortality trends were assessed over time. The Cox proportional hazard model, with calculation of hazard ratio (HR) and 95% coincidence interval (CI), was used for univariate and multivariate regression analyses. The cohort (median age 69 years, 57% male) was elderly and multimorbid, with high prevalence of coronary artery disease (95%), hypertension (91%), and chronic kidney disease (56%). Guideline-directed medical therapy was suboptimal: while beta-blocker and diuretic use was high (87% and 79%, respectively), utilization of aldosterone antagonists and ARNI was low (40% and 0.7%, respectively). Only 32.7% received multicomponent HF therapy. The overall 5-years (0.02-5.09) survival rate was 59.9%. Approximately half (48%) of patients died in the first year, the remaining deaths occurred in 2-nd, 3-rd and 4-th years (15%, 17%, and 20%, respectively), and deaths were recorded during 5-th and 6-th years of follow-up. Kaplan-Meier survival analysis showed that left ventricular ejection fraction (LV EF) was strongly associated with 5-years survival. In patients with reduced and moderately reduced LV EF 5-years survival was significantly lower than that in those with preserved LV EF (50.0% and 45.7% versus 70.4%, respectively). No significant difference was found only when comparing the survival curves of patients with moderately reduced and reduced LV EF (chi-square = 0.014; p = 0.906). The leading cause of death was decompensation of HF (65.2%), followed by sudden cardiac death (15.2%). Multivariate analysis showed that age (HR 1.03 per 1-year increase; 95% CI 1.01-1.06; p = 0.017), weight loss >4.5 kg in 5 days in response to therapy (HR 3.49; 95% CI 1.82-6.68; p < 0.001), anemia (HR 2.83; 95% CI 1.47-5.46; p = 0.002), obstructive sleep apnea syndrome (HR 4.43; 95% CI 1.91-10.28; p = 0.001), and HF NYHA functional class IV (HR 4.79; 95% CI 1.50-15.34; p = 0.008) were independent predictors of 5-years all-cause mortality in HF patients. This study identifies a high early mortality phenotype in a real-world HF population, strongly associated with significant gaps in guideline-directed therapy. The findings underscore the urgent need for early aggressive optimization of treatment, particularly in the high-risk period following diagnosis or destabilization of HF, to improve long-term survival.
Since Russia's full-scale invasion of Ukraine in 2022, casualties have frequently sustained extensive soft tissue injury and contamination requiring complex wound care and prolonged hospitalization. To characterize in-country care, we conducted a retrospective case series of adult patients with conflict-related traumatic wounds to describe wound characteristics, microbiologic testing, antibiotic use, and resistance patterns during active conflict in Ukraine. We conducted a retrospective case series to identify a consecutive population of adult patients treated at a single, referral hospital in western Ukraine for wounds management. Structured medical record abstraction was performed. The primary outcome was prevalence of complex traumatic wounds. Secondary outcomes included prevalence of antibiotic resistance among cultured wounds, surgical amputation associated with the wound, and length of hospital stay. Descriptive statistics were calculated for all variables. One hundred patients with conflict-related traumatic wounds were included. All were male with injuries occurring on the eastern frontlines from blast-related mechanisms. Median time from injury to hospitalization at study facility was 25.5 days. Overall, 95% of wounds met the case definition of a complex wound, predominantly due to presence of wound necrosis (90%). Wound cultures were obtained in half of patients (51%) with 24% (n=12) showing significant positive bacterial growth. Antibiotic resistance was identified in 9 of the 12 cultures. Nearly all patients received intravenous antibiotics (98%) for a mean duration of 7.3 days. Surgical debridement was performed in 99% of patients, while 2% underwent amputation during hospitalization. Hospital length of stay was a median of 14 days. In this cohort of conflict-related traumatic wounds in Ukraine, intravenous antibiotics were used extensively in a manner consistent with cautious, risk-averse combat trauma care. These findings primarily reflect the challenges of clinical decision-making in austere, high-risk environments and underscore the need for supportive, wartime-adapted stewardship frameworks. (J Trauma Acute Care Surg. 2026;000: 000-000. Copyright © 2026 Wolters Kluwer Health, Inc. All rights reserved). Level V - Case Series / Epidemiological.
Antineoplastic therapy may exert toxic effects on multiple organ systems in patients with hematologic malignancies. This is particularly relevant for individuals with indolent non-Hodgkin lymphoma treated with anthracycline-containing regimens, which carry a well-documented risk of cardiotoxicity. A case-control study was conducted at medical institutions in Samara, Russia, enrolling 72 patients diagnosed with grade 1-2 follicular B-cell non-Hodgkin lymphoma. All participants were administered six cycles of R-CHOP immunochemotherapy as clinically indicated. The primary objective was to identify early biomarkers of treatment-related cardiotoxicity. The study identified three parameters as the most sensitive indicators of cardiovascular toxicity: prolongation of the corrected QT interval (QTc), reduction in left ventricular global longitudinal strain, and elevation of N-terminal pro-B-type Natriuretic Peptide (NT-proBNP) levels. Additionally, the authors propose prognostic models to predict the presence of cardiotoxicity at 3 and 6 months of treatment. Comparison of the study's findings with previously published data revealed full consistency with the existing medical literature and further substantiates the authors' assertion regarding the prognostic utility of the identified laboratory and instrumental markers in the early detection of cardiotoxicity. Incorporating these biomarkers into routine cardiovascular monitoring protocols facilitates early detection of cardiotoxicity in patients with hematologic malignancies, enabling timely therapeutic adjustments and optimizing clinical management.
Crystalline rock massif of the Yeniseiskiy site (Krasnoyarsk region) is considered for the disposal of radioactive waste in the Russian Federation. In this study the resistance of different types of rocks located at target depths in the site of geological disposal facility (gneisses, dolerites, and carbonatized fissure filling) to dissolution by groundwater was simulated by short-term stage-by-stage treatment with 18 % HCl solution and aqua regia. The impact of dissolution on isolation properties was also investigated. A high sorption capacity to Cs(I) and Eu(III) which chemical behavior is similar to Am (III) and Pu (III) of gneiss, dolerite, and fissure filling samples was established. During the studies of sorption properties, it was found that the greatest influence on the retention of Cs by gneiss and dolerite have the specific surface area (SSA) value. This effect is most pronounced for gneiss due to the increased available surface area of mica minerals biotite and muscovite. The retention effect of the fissure filling material is mainly determined by the content of mixed-layer illite-smectite clay minerals and chlorite. It was found that the greatest influence on the retention of europium by gneiss and mineral fissure filling is the content of chlorite in the samples. The obtained results reflect the resistance of the host rock of the Yeniseiskiy site to the most aggressive acid environments, which allows assessing the stability of their isolation properties for a long-term perspective.
Chlorins are widely used chromophores in photodynamic therapy, yet their performance is often limited by aqueous aggregation, nonoptimal biodistribution, insufficient control over intracellular localization, and microenvironmental constraints that reduce photochemical efficiency in vivo. This review surveys chlorin platforms in the context of these limitations and examines how heteroatom engineering can help overcome them by integrating photophysical tuning with delivery and targeting functions. Particular attention is given to phosphorus- and sulfur-containing modifications as modular tools to regulate charge, polarity, and noncovalent interactions, thereby improving formulation stability and enhancing selectivity. Phosphorus motifs are discussed as degradable hydrophilizing handles and as triphenylphosphonium tags that bias accumulation toward mitochondria, while sulfur-based substituents and linkers are considered for spectral tuning and redox-responsive activation that can increase targeting and selectivity in complex biological media.
This prospective open-label comparative study evaluated the efficacy of various conservative treatments for acute anal fissure (AAF) in accelerating epithelialization and reducing pain. A total of 120 patients with symptom duration ≤6 weeks were randomized into four groups: control (hygiene only), dietary therapy (fiber-rich diet + psyllium), monotherapy with a sphincter relaxant (0.2% nitroglycerin ointment), and combined therapy (diet + nitroglycerin). The primary outcome was time to complete epithelialization; secondary outcomes included pain dynamics on the Visual Analog Scale (VAS) and incidence of chronic fissure. Results demonstrated that combined therapy achieved the shortest epithelialization time (10.5±1.5 days), which was significantly shorter than both monotherapy groups and the control (p<0.01). The combined regimen also produced the most pronounced pain reduction from day 3 onward and completely prevented the development of chronic fissure. Dietary modification and nitroglycerin alone improved outcomes but were inferior to the combined approach. In conclusion, the combination of dietary intervention and topical nitroglycerin represents the most effective conservative strategy for AAF, promoting faster healing, superior pain control, and prevention of chronicity.
Both the minimal size of optically switched magnetic bits and the wavelengths of optically excited spin waves in optomagnonic devices are fundamentally diffraction limited. Here, we propose and experimentally demonstrate a novel method to overcome these limitations by using a specially designed magnetophotonic waveguide structure. This structure enables the creation of a sign-changing profile of the inverse Faraday effect (IFE) induced in the magnetic film by the circularly polarized femtosecond laser pulse tuned to the resonance of the optical TE guided mode. The spatial period of the IFE profile is subdiffractive, which allows for the launch of narrow band exchange-dominated magnetostatic spin waves. As experimentally demonstrated, their wavelengths are around 300 nm, and they can potentially be reduced to 100 nm. This opens new horizons for optomagnetic applications, ranging from logic elements to data processing devices.
Two isoforms of the 90-kDa heat shock protein (Hsp90), stress-inducible Hsp90α and constitutively expressed Hsp90β, function in mammalian cells as molecular chaperones that promote the folding of specific client proteins involved in essential cellular processes and regulatory pathways. A number of Hsp90 client proteins take part in cancer progression, and the inhibition of Hsp90 induces the degradation of oncogenic client proteins and cancer cell death. Hsp90 inhibitors specific for individual Hsp90 isoforms have a significant potential for the development of anticancer therapeutics due to reduced toxicity. Cells with knocked-out genes encoding Hsp90 isoforms represent excellent cellular models to investigate the rearrangement of the cell chaperone machinery in response to the suppression/loss of the Hsp90 isoforms. Recently, we have shown that the knockout of the HSP90AA1 gene encoding Hsp90α in human fibrosarcoma HT1080 cells does not affect basic cellular processes in normal and stressful conditions, which suggests an adaptation of the cell chaperone machinery to the loss of Hsp90α. Here, we demonstrated that the lack of Hsp90α in HT1080 cells leads to an up-regulation of the constitutively expressed Hsp90β and several important Hsp90 co-chaperones (Aha1, Hop, and others). The expression of the major chaperones of the Hsp70 machinery (Hsp70-1, Hsp70-2, Hsc70) was also significantly induced. The components of the prefoldin-chaperonin folding arm and PFDL, R2TP, and R2SP complexes, as well as the major mitochondrial chaperones, were also largely up-regulated in Hsp90α-KO cells, while the expression of ER-resident chaperones/co-chaperones was either repressed or did not change. We demonstrated here for the first time an adaptation of the cell chaperone machinery to the loss of the Hsp90α chaperone, which may be important for understanding the molecular mechanisms of action of Hsp90α-specific inhibitors and elaborating new therapy strategies in combating cancer, including the combination of Hsp90α-targeted therapy.
Approximately 25% of patients with chronic rhinosinusitis (CRS) have recurrence after endoscopic sinus surgery (ESS). The goal is to analyze and integrate research on individual and genetic factors of recurrence in CRS patients following ESS. A systematic review and meta-analysis were performed using PRISMA criteria. Various databases were searched from January 2008 to May 2025. ESS studies with adults with CRS reported results based on clinical or genetic factors. The Newcastle-Ottawa Scale and five dimensions of bias were examined study quality. Pooled odds ratios with 95% confidence intervals were estimated using a random-effects DerSimonian-Laird model. Heterogeneity was assessed using I2, publication bias using funnel plots and Egger test, and evidentiary certainty using GRADE. A total of 17 trials with 40,059 individuals were examined. Asthma, non-steroidal anti-inflammatory drug (NSAID) intolerance, allergy, and higher Lund-Mackay scores (LMSs) were significant clinical predictors of recurrence. TAS2R38 polymorphisms had poorer outcomes, but only 4 trials were included. Asthma, NSAID intolerance, allergy, higher LMS, and TAS2R38 polymorphisms are significant predictors of recurrence in CRS following ESS. These results support the use of comorbidities, radiologic severity, and genetic biomarkers in preoperative risk classification, emphasizing the need for larger, standardized, and multi-ethnic research.
The reactivity of the orthometalated [(N^C)AuCl2] complex (N^C-pyridyl-benzothiophene) toward a series of terminal alkynes has been investigated. The reactions afford products containing a C-coordinated benzo[4,5]thieno[2,3-a]quinolizin-5-ium aromatic fragment bound to an Au(I) center. The obtained aromatic systems can be isolated in the free state through reaction of the Au(I) complexes with a protonated phosphonium cation. The studied reaction sequence may be considered a novel strategy for expansion of condensed aromatic systems via 1,4-addition of alkynes to an orthometalated N^C ligand bound to an Au(III) center. The mechanism of this transformation in the gold coordination sphere was investigated theoretically by application of the Double Anharmonic Downward Distortion Following methodology, revealing the details of the coordinated ligands transformations and confirming the key role of the solvent in determining the reaction pathway. Isolation and characterization of the Au(I) complex shed light on the mechanism of related catalytic reactions. The results obtained are of a general nature and pave the way for further development of this chemistry with the wider range of N^C and alkyne ligands, enabling the directed synthesis of new condensed aromatic systems.
Posttransplantation cyclophosphamide (PTCy)-based graft-versus-host disease (GVHD) prophylaxis is an emerging standard of care in allogeneic hematopoietic cell transplantation (HCT), however, it should be combined with other immunosuppressive agents in unrelated and haploidentical allografts. These combinations have not been previously compared in randomized clinical trials. We compared most common combination of PTCy, tacrolimus (Tac) and mycophenolate mofetil (MMF) to a new calcineurin-free combination of PTCy and ruxolitinib (PTCy-Ruxo). The multicenter prospective open-label phase II non-inferiority randomized trial compared GVHD PTCy-Ruxo prophylaxis to PTCy-Tac-MMF in unrelated and haploidentical donor HCT. The study recruited 128 adult patients with acute myeloid leukemia and acute lymphoblastic leukemia in complete remission. Patients were randomized 1:1 and stratified by donor type and disease risk index. PTCy in both groups was administered intravenously at 50 mg/kg on days +3 and +4. Ruxolitinib was given orally at 5 mg TID during conditioning and from day+5 to 21 after HCT, and at 5 mg BID from day+22 to 150. Tac was targeted for a 5-15 ng/ml concentration. MMF was administered at 30 mg/ kg/day per os in 10/10 HLA compatible HCT and 45 mg/kg/day per os in <10/10 HLA compatible HCT from D+5 to D+35 The aim was to demonstrate non-inferiority of PTCy-Ruxo for prevention of acute grade II-IV compared with PTCy-Tac-MMF with a non-inferiority-margin of 10% and one-sided type 1 error of 2·5%.The trial was completed and registered at ClinicalTrials.gov, NCT04669210. The study met its primary endpoint of non-inferior efficacy of PTCy-Ruxo GVHD prophylaxis. Cumulative incidence of acute GVHD grade II-IV at 125 days was 12.9% vs 21.2% in PTCy-Ruxo and PTCy-Tac-MMF groups respectively (superiority p=0.20, non-inferiority p=0.0041). The acute GVHD II-IV risk difference was -8.3% (95%CI -21.2% to 4.6%) for PTCy-Ruxo. The study met its secondary endpoints of non-inferior chronic GVHD cumulative incidence at 2 years and a better safety profile with PTCy-Ruxo prophylaxis. Cumulative incidence of moderate and severe chronic GVHD was 24.2% vs 39.5% (superiority p=0.09, non-inferiority p= 0.0012). The moderate and severe chronic GVHD risk difference was -15.2% (95%CI -31.1% to 0.7%) for PTCy-Ruxo. PTCy-Ruxo prophylaxis was associated with reduced incidence of grade 2-4 acute kidney injury (1.6% vs 12.1%, p=0.02), endothelial complications (1.6% vs 13.6%, p=0.01), and severe poor graft function (21.1% vs 42.6%, p=0.01). No differences in overall survival (80.6% vs 72.5%, p=0.28) or GVHD-relapse-free survival were observed between groups (61.3% vs 48.1%, p=0.19). The study demonstrated non-inferior efficacy of PTCy-Ruxo GVHD prophylaxis compared to PTCy-Tac-MMF with a 10% margin in unrelated and haploidentical HCT. Given the improved safety profile of PTCy-Ruxo compared with PTCy-Tac-MMF this regimen warrants further exploration as an alternative to calcineurin-based regimens.
Spinocerebellar ataxias (SCAs) are a group of neurodegenerative diseases characterized by progressive cerebellar dysfunction, which leads to impaired coordination, dysarthria, oculomotor disorders, and subsequently to a marked reduction in quality of life and high disability. In addition to the main motor symptoms, patients often suffer from cerebellar cognitive-affective syndrome, depression, and sleep disturbances. Despite advances in understanding the molecular and genetic underpinnings of SCAs, there are currently no disease-modifying therapies approved by the FDA (U.S. Food and Drug Administration) or EMA (European Medicines Agency), and management remains largely symptomatic, focusing on improving quality of life and functional independence. Recent systematic reviews and clinical guidelines emphasize a combination of pharmacological, non-pharmacological, and novel gene and cell therapies that are currently under investigation, with varying levels of evidence for their efficacy. The transition to precision medicine and early intervention at the pre-ataxic stage are essential for effectively combating neurodegeneration. This review summarizes the latest data on the treatment of SCA, including existing and new treatments, their effectiveness, limitations, and future prospects.
Patients with chronic lymphocytic leukemia (CLL) exhibit elevated levels of various cytokines and increased numbers of immunosuppressive cell subpopulations. However, the relationship between cytokines and suppressor cells remains unclear. Studies in this field may contribute to a better understanding of the role of cytokines in the accumulation of suppressor cells. Serum levels of 47 cytokines in patients with CLL and healthy donors were measured using multiplex analysis. The numbers of suppressor cells, including mMDSCs, Tregs, CD14+/IDO+ monocytes, and gMDSCs in peripheral blood, were determined using flow cytometry. A significant difference in the levels of 29 cytokines was observed between primary CLL patients and healthy donors. A statistically significant increase in the numbers of mMDSCs, Tregs, and CD14+/IDO+ monocytes was observed in CLL patients compared to healthy donors, while no significant differences were noted in the CD15+/LOX-1+gMDSCs numbers between CLL patients and healthy donors. Correlations were found between the levels of several cytokines and immunosuppressive cell numbers. Among these, two cytokines, MIP-1α and M-CSF, showed a positive correlation with two suppressor cell subpopulations. Furthermore, the levels of these cytokines differed between patients with Binet stage B and stage C CLL. Our findings suggest that these two cytokines play a key role in the immunosuppression observed in CLL patients. These results, demonstrating a correlation between cytokine levels and the numbers of suppressor cells in CLL patients, are consistent with our previous hypothesis. This hypothesis states that the simultaneous action of growth factors and pro-inflammatory cytokines can lead to immune system inhibition.
The distal-to-proximal pressure ratio (dpPR) has emerged as a superior indicator compared to the diameter stenosis rate (DSR) for assessing the functional severity of carotid artery stenosis (CAS). However, unlike DSR, dpPR cannot be directly determined by vascular imaging. In this study, we developed a hemodynamic modeling method to predict dpPR based on medical images available in clinical settings. A multiscale modeling method was employed to integrate a three-dimensional (3D) hemodynamic model of CAS into a lumped-parameter model of systemic hemodynamics, while incorporating patient-specific geometric information of large cerebral arteries derived from computed tomography angiography (CTA) images. The 3D modeling method was validated through in vitro fluid dynamics experiments, while the accuracy of the resulting multiscale model in predicting dpPR was evaluated by comparing model predictions with invasive pressure wire measurements. The model-predicted dpPR values for 27 carotid artery stenoses demonstrated strong agreement with invasive measurements, with a mean relative error of - 0.8% and a standard deviation of 2.5%. dpPR was only moderately correlated with DSR (r = - 0.55, p = 0.003). Further analysis revealed that the anatomical structure of the circle of Willis (CoW) is a major factor influencing the relationship between dpPR and DSR. Constructing a multiscale model based on CTA images provides a practical approach for assessing the hemodynamic impact of CAS. The significant influence of CoW's anatomical structure on the relationship between dpPR and DSR underscores the importance of considering systemic cerebral hemodynamics when evaluating the functional severity of CAS.
Laser-engineered superhydrophobic carbon fiber fabrics (CFFs) were developed as multifunctional surfaces for passive anti-icing and active electrothermal de-icing. Two laser-based texturing strategies─direct laser ablation of carbon fibers and laser-induced transfer of aluminum micro/nanoparticles─were employed to generate hierarchical surface roughness, followed by fluorosilane chemisorption. Both approaches produced stable Cassie-Baxter wetting states with water contact angles exceeding 160° while retaining superhydrophobicity after abrasive wear, with contact angles remaining above 154° and 157° for the two coatings, respectively. Superhydrophobic CFFs exhibited pronounced anti-icing behavior, delaying ice nucleation and preserving supercooled water droplets for tens of hours at moderate subzero temperatures. Under weak electrothermal heating, anti-icing performance was maintained down to -40 °C, where small droplets frequently evaporated before freezing. Compared to hydrophilic and hydrophobic fabrics, superhydrophobic CFFs enabled ice removal predominantly via interfacial sliding rather than melting, leading to substantial reductions in de-icing energy consumption and time. In particular, one optimized coating reduced ice removal time by more than a factor of 4 and total energy consumption by more than a factor of 3 relative to the untreated fabric. A clear distinction was observed between the two texturing strategies. Aluminum-textured CFFs exhibited lower electrical resistance and more efficient heat delivery to the ice-fabric interface, minimizing the total energy required to initiate ice sliding, whereas laser-textured CFFs showed higher electrical resistance and faster surface temperature rise, resulting in shorter de-icing times. These results demonstrate a decoupling of energy efficiency and temporal response in electrothermal de-icing, enabled by laser-induced surface texturing. Overall, this work establishes superhydrophobic CFFs as durable, low-power platforms for combined passive anti-icing and active electrothermal de-icing in severe cold environments.
Traumatic brain injury presents a significant challenge, characterized by complex pathologies including neuroinflammation and axonal degeneration with limited treatment options. One of the promising areas of traumatic brain injury treatment is cell therapy. However, a critical aspect of this therapy is the method of stem/progenitor cell administration. This study aimed to evaluate the therapeutic potential of glial progenitor cells derived from induced pluripotent stem cells after intra-arterial administration in an experimental model of traumatic brain injury of male Wistar rats. Neurological status was assessed using the limb-placing, cylinder, and beam walking tests. Lesion volume was quantified by magnetic resonance imaging. Markers of inflammation and neurogenesis were analyzed using immunofluorescence staining and quantitative reverse transcription polymerase chain reaction. Cell migration was tracked via magnetic resonance imaging and histology. Intra-arterial administration provided targeted delivery of cells into the cerebral vasculature. The cells successfully crossed the blood-brain barrier, migrated into the brain parenchyma, and were detectable for up to 48 hours. Transplantation led to significant improvement in sensorimotor function, reduced neuroinflammation in the injured area, and promoted neurogenesis. The observed therapeutic effects are likely mediated by the factors secreted by glial progenitor cells, which possess anti-inflammatory and regenerative properties (paracrine signaling effect) and/or by their transient interactions with the target cells (juxtacrine signaling effect). Glial progenitor cells derived from induced pluripotent stem cells and delivered via the intra-arterial route show promise for the treatment of traumatic brain injury by reducing inflammation and enhancing neurogenesis.
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Here, we report on a study of nickel germanate formation in the Ni(OH)2-GeO2 system under solid-phase synthesis conditions in the 500-800°C temperature range and on the research of electrochemical performance of Ni2GeO4-based electrodes. It is shown that the Ni2GeO4 formation occurred at temperatures around 700°C, and the process began with the melting of the nonautonomous phase GeO2 at Tm2n = 725 ± 112°C. The nickel germanate-based electrodes showed a rapid decrease in capacity over 40 cycles. However, starting from the 80th cycle, a gradual increase in capacity was observed from 190 to 528 mAh/g at the 270th cycle. We attribute this increase in capacity to evolution in the specific surface area and porosity of the electrode material during long-term cycling.
We investigated whether maternal heart rate variability (HRV) mediates the association between maternal postpartum depressive symptoms and preterm infant autonomic regulation in the early postnatal period. Data derived from 82 mothers and 97 preterm infants (gestation<37 weeks) (Mean [SD] gestational age (GA): 33.4 [2.15] weeks). We assessed preterm neonate HRV within 24 h after birth (T1), on days 3-4 (T2), and for neonates born before 35 weeks GA, at 35-36 weeks postmenstrual age (PMA) (T3). Maternal HRV measurements were carried out between the 3rd and 6th day after birth. HRV features included time-, frequency-domain, and non-linear measures. Edinburgh Postnatal Depression Scale was used to screen possible depressive symptoms in new mothers. Zero-order Pearson correlations and mediation analyses were carried out. Results: a) indicated that maternal depressive symptoms, following a preterm birth, are reliably associated with maternal autonomic regulation across all time points; b) provided limited evidence of a direct effect of depressive symptoms on preterm neonate HRV (MedianNN, T2); and c) provided evidence suggesting an indirect effect between maternal depressive symptoms and infant autonomic function via maternal HTI (T1). Maternal depressive symptoms, after a preterm birth, are associated with altered maternal autonomic regulation but do not directly or indirectly (via maternal HRV) influence infant autonomic function in early postnatal life. These findings may inform early interventions for assessing maternal HRV as a promising tool for detecting maternal mental health and highlight the role of alternative pathways linking maternal mental health to preterm infant development.
In this study, we present a comprehensive set of experimental data aimed at uncovering the mechanisms and regularities governing the deformation behavior of composites reinforced with continuous carbon fibers (CF) based on thermoplastic polymers. This work describes data extraction techniques that can later be used to optimize the mechanical properties of such structures using neural network models. This paper examines the thermoplastic polymer polysulfone (PSU) of the Ultrason S 2010 brand, which was used as the matrix material for the composites, while high-strength Toray T700SC fibers were used as the reinforcing fibers. Composite samples in the form of rods with a diameter of 1 mm were obtained by impregnating the fibers with a solution of polysulfone in N-methyl-2-pyrrolidone, followed by solvent removal. The collected dataset contains more than 600 tensile test results, including load-strain diagrams for different test conditions, data on the failure mechanisms of the specimens, and SEM images of the specimen microstructure in cross and longitudinal sections. This dataset will be useful for ML model development.