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This study presents the first dedicated bibliometric analysis of artificial intelligence (AI) and deep learning applications in pediatric radiology and medical imaging, mapping the intellectual structure of a rapidly evolving field. A total of 2688 articles and conference proceedings published between 2005 and 2025 were retrieved from the Web of Science Core Collection and analyzed using Bibliometrix R and VOSviewer. The findings reveal exponential growth in publications, from 7 papers in 2005 to 559 in 2025, with journal articles dominating the corpus (85.9%). The most-cited contributions, led by Kermany et al. (2018) with 2886 citations, are predominantly technical feasibility studies rather than clinical outcome trials, indicating a field that has advanced methodologically but remains in early stages of clinical translation. Thematic mapping identifies convolutional neural networks, pneumonia, and transfer learning as Motor Themes representing methodological maturity in chest imaging, while neuroimaging and image segmentation clusters occupy Niche Themes, reflecting insular development with limited cross-field connectivity. Geographic analysis reveals concentrated co-authorship along US-China and US-Europe corridors, with African, Latin American, and Southeast Asian institutions largely absent from knowledge production networks. Eight of the ten most productive affiliations are North American, highlighting structural inequities that risk producing AI tools optimized for high-resource settings rather than the global pediatric population. This analysis provides an empirical foundation for reorienting the field toward clinical validation, geographic inclusion, and methodological integration across isolated research communities.

To integrate current evidence and expert consensus on safe, effective exercise prescription in Duchenne and Becker muscular dystrophy (DMD/BMD), translating key pathophysiological principles into practical clinical guidance. Proceedings from the June 2025 Parent Project Muscular Dystrophy meeting, Translating Exercise Research in Dystrophinopathy to the Clinic, were synthesized. Faculty reviewed dystrophinopathy pathology and exercise physiology, analyzed data from clinical trials and pilot studies, summarized outcome-measure selection, and discussed pragmatic solutions to overcome barriers. Through interactive discussion, expert opinion on clinical management was aligned with exercise prescription frameworks (FITT) and clinic resources. Exercise modality and dosing are understudied in dystrophinopathies yet represent critical factors for safe and effective interventions. In DMD, assisted low-intensity cycling can stabilize function and moderate isometric protocols can increase strength without evidence of injury. In BMD, aerobic training and supervised low-intensity resistance generally improve fitness/strength, whereas high-intensity loads may pose risks. Pragmatic assessments support monitoring and anticipatory care. Individualized prescriptions, supervised onboarding, and social engagement may mitigate dosing uncertainty, equipment access, and adherence barriers. The clinical framework should emphasize movement observation, postural strategies, oculomotor and cognitive-motor screening, and documentation for insurance coverage. Safety guidance emphasizes physician clearance, submaximal dosing, fatigue management, and clear "red flag" escalation pathways. Contemporary data and expert consensus support integrating conservative, systematically monitored exercise as an essential adjunct to DMD/BMD care. Available evidence indicates low-to-moderate aerobic activity and moderate-intensity isometric exercise appear feasible and safe when individualized and supervised. Further controlled studies should refine dosing and strengthen disease-stage-specific guidance.

Allergic rhinitis (AR) is a prevalent chronic inflammatory condition mediated by immunoglobulin E (IgE). In traditional Chinese medicine (TCM), AR is categorized under the term "bi qiu", with its core pathogenesis attributed to dysfunction of the lung, spleen, and kidney, compounded by external pathogenic invasion. Chinese herbal formulas, such as Yupingfeng San (Jade Wind Screen Powder), documented in the Danxi Xinfa, have demonstrated therapeutic efficacy in alleviating AR symptoms, supported by centuries of clinical application in China. This review systematically synthesizes recent advances in the multifactorial pathogenesis of AR and evaluates the therapeutic potential of TCM based on clinical efficacy data and mechanistic studies. It further elucidates the capacity of TCM to modulate AR-associated immune dysregulation, epithelial barrier dysfunction, and microbial imbalance through multi-target mechanisms. By doing so, the review establishes a theoretical framework supporting the application of TCM in AR management and proposes innovative TCM-based strategies to overcome limitations associated with conventional treatments. This paper provides a systematic summary of the pathogenesis of allergic rhinitis (AR) and evaluates the clinical efficacy and molecular mechanisms of traditional Chinese medicine (TCM) in the treatment of AR. The findings are based on a comprehensive literature search conducted in PubMed, Web of Science, EMBASE, Cochrane Library, Wanfang Database, and China National Knowledge Infrastructure (CNKI). The search strategy employed keywords including "allergic rhinitis," "pathogenesis," "traditional Chinese medicine," "Chinese herbal medicine," "herbal medicine," and "active components of Chinese medicine.""treatment," "immunotherapy," and "biologics" in various combinations. &#x2460; Original clinical studies, observational studies, randomized controlled trials (RCTs), and meta-analyses related to the topic.&#x2461; Articles published in the last five years (2020-2025) on AR pathogenesis and TCM treatment, with seminal earlier studies on classical mechanisms (e.g., Th1/Th2 imbalance) also included to provide foundational context.&#x2462;Research on the mechanisms, treatment strategies, or therapeutic effects of Traditional Chinese and Western medicine in AR. &#x2460; Abstracts, conference proceedings, opinion pieces, or non-peer-reviewed articles. &#x2461; Studies with low methodological quality (e.g., lacking control groups). &#x2462; Irrelevant studies or those focusing on unrelated diseases.All plant names have been verified against The World Flora Online (http://www.worldfloraonline.org, accessed February 25, 2026) to ensure compliance with current taxonomic standards. A PRISMA flowchart documenting the literature screening process has been provided in the Supplementary Materials (Figure S1). The pathogenesis of AR involves Th2 cell polarization, impairment of the mucosal epithelial barrier, dysbiosis of the microbiota, and neuro-immune interactions. Conventional treatments are often associated with limitations, including adverse effects and high costs. TCM has been shown to ameliorate AR symptoms through mechanisms such as regulating transcription factors including NF-&#x3ba;B and GATA3, restoring epithelial tight junction proteins (e.g., ZO-1 and occludin), and modulating gut microbiota composition, including increasing the production of short-chain fatty acids (SCFAs). Clinical studies have provided preliminary evidence for the safety and efficacy of TCM, both as monotherapy and in combination with Western medicine, for the management of AR.However, most mechanistic insights are derived from animal models, and direct translational evidence to human applications remains limited. Notably, a randomized controlled trial (n&#xa0;=&#xa0;60) reported that nasal lavage with Glycyrrhizae Radix et Rhizoma (licorice) significantly improved SNOT-22 scores (from 27.9&#xa0;&#xb1;&#xa0;15.5 to 13.2&#xa0;&#xb1;&#xa0;9.6, p&#xa0;<&#xa0;0.001) and reduced nasal airway resistance (p&#xa0;<&#xa0;0.001), with effects superior to those of corticosteroid or saline lavage. TCM demonstrates preclinical potential in the treatment of AR, which is characterized by multifactorial etiology, through holistic and multi-target regulatory mechanisms. Further validation in human studies is needed. Future research should prioritize large-scale, multi-center clinical trials and leverage advanced biotechnological approaches to facilitate the standardization and global acceptance of TCM in allergy management.

Conversational agents (CAs) are increasingly used in mental health care to enhance access and engagement. However, their safe, ethical, and user-sensitive design remains a challenge. Despite growing attention to trauma-informed approaches in human-computer interaction, there is limited work on how the trauma-informed care (TIC) framework could be applied in the design of mental health CAs and no comprehensive synthesis to date. Guided by the Substance Abuse and Mental Health Services Administration's TIC framework, this scoping review explored how TIC principles (safety; trustworthiness and transparency; collaboration and mutuality; empowerment, voice, and choice; peer support; and cultural, historical, and gender issues) are currently represented in the design and evaluation of mental health conversational agents (MHCAs) and identified gaps and opportunities to promote more trauma-informed design practices. Online databases, as well as a secondary survey of citation lists from an initial search, were used to identify English-language journal articles and conference proceedings from 2000 to 2024 that empirically evaluated an independent, web- or app-based, unassisted CA used for mental health and included concepts from TIC. Our analysis included 38 publications (n=28, 73.7%, published in 2020 or later) covering 28 distinct MHCAs. Most studies used experimental methods (n=23, 60.6%) or user studies (n=11, 28.9%), with samples skewed toward female (men: mean 34.92%, SD 18.64%), young in age (mean 32.52, SD 14.6 y), and predominantly nonclinical (n=29, 76.3%). MHCAs were largely rule-based prototypes. No studies explicitly referenced the TIC framework as a guiding lens for MHCA design or evaluation. A total of 26 studies referenced terminology from TIC core principles but rarely defined them, while all 38 included language that could be linked to one or more principles. Overall, TIC-related concepts appeared most often within intervention design descriptions, qualitative assessments, or as items embedded in questionnaires evaluating broader constructs. Trustworthiness and transparency, safety, empowerment, voice and choice, and collaboration and mutuality were comparatively well addressed, while peer support and cultural, historical, and gender issues were largely absent. Design recommendations, where present, were relatively broad and emphasized secure, customizable, reliable, human-like, and context-sensitive MHCAs that offered multimodal interaction, goal setting and tracking, and transparency. Studies did not self-identify as using Substance Abuse and Mental Health Services Administration's framework for TIC, making it more difficult to identify its elements. The fragmented terms, disciplines, and metrics used make it difficult to draw more systematic conclusions about the current research landscape related to TIC, but our analysis indicates TIC to be a descriptive and potentially unifying framework and provides a starting point for the explicit trauma-informed MHCA research and design.

Cardiotoxicity associated with HER2-targeted therapies represents an important clinical concern in the management of HER2-positive breast cancer, particularly as survival improves and patients are exposed to prolonged or sequential treatments. Trastuzumab has significantly enhanced outcomes but is associated with cardiac dysfunction, which may limit its use in patients with preexisting cardiovascular risk factors. With the expanding use of newer HER2-targeted agents, a clear understanding of their cardiac safety profiles is essential for optimizing long-term patient care. This review evaluates the incidence, mechanisms, and clinical relevance of cardiotoxicity associated with trastuzumab and novel HER2-targeted therapies, including monoclonal antibodies, antibody - drug conjugates, and tyrosine kinase inhibitors. A literature search was conducted using PubMed and major oncology meeting proceedings, including the American Society of Clinical Oncology (ASCO) Annual Meeting and the San Antonio Breast Cancer Symposium. Randomized clinical trials, pooled analyses, long-term follow-up studies, and selected real-world observational studies reporting cardiac outcomes were reviewed. Available evidence suggests that trastuzumab-related cardiotoxicity remains clinically relevant, whereas newer HER2-targeted agents generally demonstrate favorable cardiac safety profiles with mostly asymptomatic and reversible events. These findings support individualized, risk-adapted cardiac monitoring strategies to balance oncologic efficacy with cardiovascular safety.

Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases and remains a leading cause of cancer-related mortality worldwide. Advances in molecular characterization and tumor biology have driven the development of antibody-based therapies targeting immune checkpoints, angiogenesis, and oncogenic signaling pathways critical for tumor growth and progression. Among these agents, Ramucirumab, Atezolizumab, and Amivantamab have demonstrated significant clinical efficacy in selected NSCLC populations. This review summarizes the mechanisms of action, pivotal clinical trials, and current clinical evidence supporting the use of ramucirumab, atezolizumab, and amivantamab in the management of advanced NSCLC. Relevant literature was identified through searches of PubMed, clinical trial registries, and recent international conference proceedings, with an emphasis on therapeutic efficacy, safety profiles, and rational combination strategies. Ramucirumab, a monoclonal antibody targeting vascular endothelial growth factor receptor-2 (VEGFR-2), has shown a survival benefit when combined with docetaxel in patients with previously treated advanced NSCLC. Atezolizumab, a programmed death-ligand 1 (PD-L1) immune checkpoint inhibitor (ICI), has become a cornerstone of NSCLC treatment across multiple disease stages, both as monotherapy and in combination with chemotherapy. Amivantamab, a bispecific antibody targeting both epidermal growth factor receptor (EGFR) and mesenchymal-epithelial transition factor (MET), has demonstrated robust and durable clinical activity in patients with EGFR exon 20 insertion-mutated NSCLC. Collectively, these agents highlight the expanding role of antibody-based therapies in NSCLC and underscore the importance of biomarker-driven patient selection and treatment personalization. Ongoing research into resistance mechanisms, predictive biomarkers, and combination approaches is expected to further refine the integration of antibody-based strategies in precision oncology for NSCLC.

Propyl gallate (PG), a common food antioxidant, has demonstrated remarkable potential as a photosensitizer for antimicrobial photodynamic inactivation under UV-A irradiation. Against Pseudomonas fluorescens, PG-mediated treatment achieved an exceptional bacterial reduction exceeding 7 log CFU/mL. Mechanistic studies revealed extensive cellular damage through DNA degradation and protein denaturation, as visualized via electron microscopy, showing compromised membrane integrity. Antimicrobial action proceeded through the generation of OH-radicals, H2O2, and superoxide (O2&#x2022;-), with intracellular reactive oxygen species accumulation confirmed by confocal microscopy. Beyond in-vitro grass carp fillet applications, PG-mediated reduced bacterial contamination by 3.5 log CFU/g while preserving food quality. PG-mediated based samples exhibited 47% lower lipid oxidation, 33% higher sulfhydryl content retention, and 29% reduction in total volatile basic nitrogen compared to the control ones. Additionally, the pH stability and color parameters remained consistent throughout storage. These findings establish PG-mediated photodynamic treatment as a combined antimicrobial and antioxidant functionality, simultaneously ensuring microbial safety and maintaining nutritional quality in seafood preservation.

Sturge-Weber syndrome (SWS) is a rare congenital neurocutaneous disorder presenting unique anesthetic challenges due to extensive vascular malformations. Key considerations include difficult airway management due to extensive facial and oral angiomas, seizure control, and maintaining stable intracranial and intraocular pressures. This case report discusses the perioperative management of a 57-year-old female with SWS undergoing dental surgery under general anesthesia and synthesizes the current literature on anesthetic considerations and management. Preoperative examination revealed a facial port-wine stain covering more than 75% of the face, extensive oral angiomas, macroglossia, and severe lip hypertrophy, raising concerns for difficult airway management and risk of hemorrhage. A rapid sequence induction was performed following upright preoxygenation, and video laryngoscopy provided a grade I view of the glottis. Endotracheal intubation was accomplished atraumatically, and the case proceeded uneventfully. The patient was extubated but experienced mild desaturation in the post-anesthesia care unit, prompting overnight observation before discharge at baseline oxygenation. This case highlights the importance of anticipating and planning for difficult airway management, maintaining vigilance for perioperative seizure control, and implementing strategies to minimize elevations in intracranial and intraocular pressures.

Integrating evidence-based practice (EBP) with artificial intelligence (AI) has the potential to enhance healthcare quality, clinical decision-making, and system efficiency. Understanding healthcare providers' knowledge, attitudes, and practices (KAP) toward this integration is essential to inform education and implementation strategies. This study aimed to evaluate healthcare providers' knowledge, attitudes, and practices regarding the integration of EBP and AI in Saudi Arabia. A descriptive cross-sectional study was conducted between October and December 2025 among licensed healthcare providers working in governmental and private institutions across Saudi Arabia. Data was collected using a validated, self-administered questionnaire. Descriptive and inferential analyses, including chi-square tests and logistic regression, were performed using SPSS, with p&#x2009;<&#x2009;0.05 considered statistically significant. A total of 503 healthcare professionals participated. Overall mean scores indicated moderate knowledge of AI and EBP (mean&#x2009;=&#x2009;2.45&#x2009;&#xb1;&#x2009;0.72), generally positive attitudes (mean&#x2009;=&#x2009;2.46&#x2009;&#xb1;&#x2009;0.69), and lower levels of practice (mean&#x2009;=&#x2009;2.22&#x2009;&#xb1;&#x2009;0.75). Knowledge was significantly associated with professional role (p&#x2009;=&#x2009;0.009), years of experience (p&#x2009;=&#x2009;0.014), institution type (p&#x2009;=&#x2009;0.003), and academic qualification (p&#x2009;<&#x2009;0.001). Practice was significantly associated with years of experience (p&#x2009;=&#x2009;0.001) and educational qualification (p&#x2009;=&#x2009;0.027), while attitudes differed significantly only by age group (p&#x2009;=&#x2009;0.012). Significant positive correlations were observed among KAP domains (r&#x2009;=&#x2009;0.37-0.45, p&#x2009;<&#x2009;0.001), with practice showing the strongest association with the overall KAP score (r&#x2009;=&#x2009;0.90). Healthcare providers in Saudi Arabia demonstrate moderate knowledge and positive attitudes toward integrating AI and EBP; however, practical application remains limited. Targeted training and institutional support are needed to bridge the gap between knowledge and practice and promote effective integration into routine healthcare delivery.

The greyhound has been strongly selected for competitive racing. Here, we present the first comprehensive population genomic analysis of racing greyhounds (n = 54) in the context of 14 other dog breeds (n = 352) using 473K single nucleotide polymorphism (SNP) genotypes. Inbreeding in the greyhound (FROH = 0.47) was higher than in most other breeds, reflecting positive selection for athletic traits but also raising concerns about potential health impacts. Although very long runs of homozygosity (ROH) were less common in the greyhound than in some breeds, large ROH islands suggest that selection for advantageous traits is relatively recent. Genomic regions under strong selection overlapped with ROH islands on CFA2, CFA4, CFA9, CFA10, CFA25 and CFA28 and contained candidate genes with marked allele frequency differences relative to other breeds. Notably, the strongest selection signal overlapped with the longest ROH island, encompassing the SLC46A3, POLR1D, FLT3, SLC7A1, MTUS2, LHFPL6, USPL1 and USP12 genes that have biological functions in vision, craniofacial morphology, neurological adaptability and skeletal, cardiac and muscle biology, implicating them in shaping the greyhound's morphological and athletic phenotype. These results provide insights into the selection pressures in the racing greyhound, identifying key genomic regions and candidate genes that may underlie racing capabilities, and importantly for animal welfare, provide a framework for managing inbreeding to optimize health and performance for future generations.

Primary aldosteronism (PA) typically presents with hypertension and hypokalemia; however, its presentation as life-threatening ventricular arrhythmias is rare and often underrecognized. We report a case of a 30-year-old woman who presented with polymorphic ventricular tachycardia manifesting as torsades de pointes. Laboratory findings revealed persistent hypokalemia, metabolic alkalosis, suppressed renin, and inappropriately elevated aldosterone. Because recurrent malignant arrhythmia conferred a high immediate risk of sudden cardiac death, genetic testing for inherited arrhythmia syndromes was initiated, and an implantable cardioverter-defibrillator was implanted for secondary prevention before genetic confirmation became available. Endocrine evaluation proceeded concurrently and ultimately established the diagnosis of PA. Subsequent genetic analysis identified a pathogenic splice-site variant in KCNH2, consistent with congenital long QT syndrome type 2 (LQTS2). A review of the literature identified 16 previously reported cases of PA-associated ventricular arrhythmia, which showed a consistent association with hypokalemia and hypertension; however, none included genetic evaluation. This case highlights the need for parallel endocrine and arrhythmia evaluation in patients with unexplained ventricular arrhythmias.

Reproductive genetic carrier screening (RGCS) is recommended preconceptionally or early pregnancy to identify the risk of autosomal recessive (AR) disorders in healthy couples. Data on shared carrier status at the couple's level remains limited in Eastern Europe. This study presents the first couple-based RGCS analysis in Western Romania. We retrospectively analyzed RGCS results from 247 couples with no known consanguinity at the time of evaluation (494 apparently unrelated individuals, aged 22-52 years), assessed at a single genetic center between 2020-2024. Next-generation sequencing was performed using an expanded panel targeting 302 genes, including 300 genes associated with AR onset disorders. This analysis was accompanied by both pre- and post-test genetic counseling. The prevalence of individual and shared carrier status and reproductive risk was assessed. Pathogenic or likely pathogenic (PLP) variants were identified in the study cohort, with an overall couple carrier frequency of 64.37%. Shared carrier status for PLP variants in the same gene was identified in 17.4%, including three couples carrying pathogenic variants in two shared genes. Additionally, 46.96% of couples carried pathogenic variants in different genes without overlapping. The most frequently shared genes with PLP variants were HFE, CFTR, SMN1, BTD, and COL7A1; 14 additional shared genes with PLP variants were associated with severe, early-onset disorders. Forty-three couples were deemed high risk for AR conditions. Their reproductive choices varied, including in vitro fertilization or proceeding with pregnancy with or without prenatal testing. Couple-based RGCS revealed a substantial burden of shared AR carrier status in Western Romania, supporting the implementation of population-level screening programs to improve reproductive risk assessment and informed decision-making.

Preceptorship is a crucial component of nursing education in the final year, as it facilitates the transition to being a registered nurse. Preceptors guide student nurses in the clinical area through supervision and development, typically employing a traditional model with multiple ward-based preceptors who focus on clinical skills. However, the role of the preceptors in shaping nursing students' career adaptability and professional identity has been underemphasized. This study evaluated a strategy of embedding a supplemental role-model mentor that provided continuous, personalized guidance during the final year of clinical placement. This study explored the influence of a newly implemented double preceptorship model on nursing students' career adaptability and professional identity. This study employed a quasi-experimental design. This study was conducted at a top-tier hospital in Guangzhou, China, from July 2023 to May 2024. The research subjects were final-year nursing students undertaking clinical placement in the hospital. The intervention group (n&#x2009;=&#x2009;39) received additional support from a supplemental role-model mentor for the entire final year, in addition to ward-based clinical preceptors in each ward area. The control group (n&#x2009;=&#x2009;32) received the traditional preceptorship model. The differences between the two groups were evaluated using the Career Adaptability Scale and the Professional Identity Scale. At baseline, no significant differences were observed between the two groups. Following the intervention, the scores in the intervention group were significantly higher than those in the control group in both career adaptability and professional identity (all p&#x2009;<&#x2009;0.05). Within-group analyses revealed a significant increase in career adaptability from pre- to post-intervention in the intervention group (p&#x2009;<&#x2009;0.05), whereas no significant change was observed in the control group. For professional identity, subscale analysis indicated significant improvements across four dimensions (except social modelling) within the intervention group (all p&#x2009;<&#x2009;0.05). The double preceptorship system, which embeds a supplemental role-model mentor in the final year of clinical placement for nursing students, appears to enhance career adaptability and professional identity, potentially leading to improved retention in the workplace after nursing education.

Mental health issues are becoming increasingly prominent among college students, and psychological resilience is a crucial factor for individuals to maintain a good mental state when facing pressure and challenges. Art therapy, especially when combined with film production, offers college students a unique way to express themselves and to regulate their emotions. This systematic review aimed to explore the application value and effects of film education combined with art therapy in promoting mental health and psychological resilience among college students. A comprehensive literature search was conducted in PubMed from 2020 to 2025 using the keywords "art therapy," "film," and "mental health." Conference proceedings, comments, and non-subject-related literature were excluded. This study was performed and reported in strict accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. A total of 128 records were initially identified, and 28 eligible studies were included after screening. The results demonstrate that integrated film education and art therapy interventions effectively support emotional expression, stress relief, meaning-making, and social communication, and contribute to the improvement of psychological resilience and mental health status in college students. This review also identifies key research gaps and provides directions for future interdisciplinary research. The findings support the implementation of film-based creative and expressive arts interventions in mental health education for university students.

Esthetic dentistry increasingly emphasizes patient-centered treatment planning and effective communication between clinicians and patients. Conventional consultation methods often rely on verbal explanations and static images, which may not adequately convey the expected esthetic outcomes. Digital Smile Design (DSD) has emerged as a modern digital tool that allows clinicians to simulate potential smile outcomes. This digital approach may improve patient understanding, enhance confidence in treatment planning, and increase patient satisfaction with the consultation process. This study aimed to evaluate the impact of DSD on patient satisfaction and treatment acceptance during esthetic dental consultation. This prospective clinical study was conducted in the Department of Restorative Dentistry and included 80 patients who sought esthetic dental treatment. Following a conventional consultation involving a clinical examination and verbal explanation of the treatment plan, patient perceptions were recorded. A digital smile simulation was then generated using the Smile Designer Pro software (Tasty Tech Ltd., London, United Kingdom) and presented to the patients. Patient understanding of the treatment plan and confidence in the proposed treatment were assessed before and after the digital smile simulation using a 5-point Likert scale. Overall satisfaction with the consultation process was evaluated using a 10-point Visual Analog Scale (VAS). Statistical analysis was performed using IBM SPSS Statistics for Windows, Version 20 (Released 2015; IBM Corp., Armonk, New York). Descriptive statistics were calculated, and pre- and post-consultation scores were compared using a paired t-test with a significance level set at p < 0.05. A significant improvement in patient understanding and confidence was observed following the DSD consultation. Scores related to the clarity of procedures, understanding of treatment duration, costs, and limitations increased significantly after digital visualization (p < 0.001). Patient confidence in the anticipated final smile, confidence in the dentist, certainty of proceeding with treatment, and ability to visualize the expected outcome also improved significantly (p < 0.001). Overall, satisfaction with the consultation process was high, with the majority of participants reporting improved communication and greater involvement in treatment planning. In addition, 85% of the patients accepted the proposed treatment following digital smile simulation. DSD significantly enhanced patient understanding, confidence, satisfaction, and treatment acceptance during esthetic dental consultation. Its integration into clinical practice may improve communication and promote predictable patient-centered treatment planning in esthetic dentistry.