搜索结果：Pharmacology

In the mid to late 1980s, studies were published that provided the first evidence for the existence of glutamate receptors that are not ligand-gated cation channels but are coupled to effector systems through GTP-binding proteins. Since those initial reports, tremendous progress has been made in characterizing these metabotropic glutamate receptors (mGluRs), including cloning and characterization of cDNA that encodes a family of eight mGluR subtypes, several of which have multiple splice variants. Also, tremendous progress has been made in developing new highly selective mGluR agonists and antagonists and toward determining the physiologic roles of the mGluRs in mammalian brain. These findings have exciting implications for drug development and suggest that the mGluRs provide a novel target for development of therepeutic agents that could have a significant impact on neuropharmacology.

暂无摘要（点击查看原文获取完整内容）

For those using drugs to treat infants and children, the integration of developmental pharmacology is crucial to appropriate clinical practice. Changes in metabolic capacity, distribution sites, and organ function all affect the way in which medications are handled in the very young. This review examines the developmental changes that profoundly affect the responses of children to medications and related therapies.

This volume provides an easy access to a review of the complex literature of kinin physiology. Like most multi-author books, the quality is variable. Some chapters are little more than an encyclopedic compilation of the literature. In other chapters, an attempt has been made to evaluate the investigations cited, with a critical eye. This volume will be of interest to libraries of medical schools and departments of pharmacology, physiology, biochemistry, and other investigative branches of medicine. The cost of $68.20 will make private purchase prohibitive for all except those who have keen interest in the area.

ADVERTISEMENT RETURN TO ISSUEPREVArticleOrganoselenium and Organotellurium Compounds: Toxicology and PharmacologyCristina W. Nogueira, Gilson Zeni, and João B. T. RochaView Author Information Laboratório de Síntese, Reatividade e Avaliacão Farmacológica e Toxicológica de Organocalcogênios, CCNE, UFSM, Santa Maria, CEP 97105-900 Rio Grande do Sul, Brazil Cite this: Chem. Rev. 2004, 104, 12, 6255–6286Publication Date (Web):November 3, 2004Publication History Received13 July 2004Published online3 November 2004Published inissue 1 December 2004https://pubs.acs.org/doi/10.1021/cr0406559https://doi.org/10.1021/cr0406559research-articleACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views8735Altmetric-Citations1597LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Antioxidants,Aromatic compounds,Hydrocarbons,Peptides and proteins,Rodent models Get e-Alerts

Ketamine—Its Pharmacology and Therapeutic Uses Paul white;Walter Way;anthony Trevor; Anesthesiology

Sustained administration of trazodone enhances serotonergic neurotransmission: In vivo electrophysiological study in the rat brain

Looks at the essential conepts in the science of pharmacology and its application to clinical practice.

暂无摘要（点击查看原文获取完整内容）

暂无摘要（点击查看原文获取完整内容）

暂无摘要（点击查看原文获取完整内容）

暂无摘要（点击查看原文获取完整内容）

暂无摘要（点击查看原文获取完整内容）

OBJECTIVE: The clinical hallmark of schizophrenia is psychosis. The objective of this overview is to link the neurobiology (brain), the phenomenological experience (mind), and pharmacological aspects of psychosis-in-schizophrenia into a unitary framework. METHOD: Current ideas regarding the neurobiology and phenomenology of psychosis and schizophrenia, the role of dopamine, and the mechanism of action of antipsychotic medication were integrated to develop this framework. RESULTS: A central role of dopamine is to mediate the "salience" of environmental events and internal representations. It is proposed that a dysregulated, hyperdopaminergic state, at a "brain" level of description and analysis, leads to an aberrant assignment of salience to the elements of one's experience, at a "mind" level. Delusions are a cognitive effort by the patient to make sense of these aberrantly salient experiences, whereas hallucinations reflect a direct experience of the aberrant salience of internal representations. Antipsychotics "dampen the salience" of these abnormal experiences and by doing so permit the resolution of symptoms. The antipsychotics do not erase the symptoms but provide the platform for a process of psychological resolution. However, if antipsychotic treatment is stopped, the dysregulated neurochemistry returns, the dormant ideas and experiences become reinvested with aberrant salience, and a relapse occurs. CONCLUSIONS: The article provides a heuristic framework for linking the psychological and biological in psychosis. Predictions of this hypothesis, particularly regarding the possibility of synergy between psychological and pharmacological therapies, are presented. The author describes how the hypothesis is complementary to other ideas about psychosis and also discusses its limitations.

暂无摘要（点击查看原文获取完整内容）

暂无摘要（点击查看原文获取完整内容）

暂无摘要（点击查看原文获取完整内容）

暂无摘要（点击查看原文获取完整内容）