Point-of-care ultrasound (POCUS) is one of the most commonly applied tools for cardiac function imaging in the clinical routine of the emergency department and pediatric intensive care unit. The prior studies demonstrate that AI-assisted software can guide nurses or novices without prior sonography experience to acquire POCUS by recognizing the interest region, assessing image quality, and providing instructions. However, these AI algorithms cannot simply replace the role of skilled sonographers in acquiring diagnostic-quality POCUS. Unlike chest X-ray, CT, and MRI, which have standardized imaging protocols, POCUS can be acquired with high inter-observer variability. Though being with variability, they are usually all clinically acceptable and interpretable. In challenging clinical environments, sonographers employ novel heuristics to acquire POCUS in complex scenarios. To help novice learners to expedite the training process while reducing the dependency on experienced sonographers in the curriculum implementation, We will develop a framework to perform real-time AI-assisted quality assessment and probe position guidance to provide training process for novice learners with less ma
With the rapid development of COVID-19 into a global pandemic, there is an ever more urgent need for cheap, fast and reliable tools that can assist physicians in diagnosing COVID-19. Medical imaging such as CT can take a key role in complementing conventional diagnostic tools from molecular biology, and, using deep learning techniques, several automatic systems were demonstrated promising performances using CT or X-ray data. Here, we advocate a more prominent role of point-of-care ultrasound imaging to guide COVID-19 detection. Ultrasound is non-invasive and ubiquitous in medical facilities around the globe. Our contribution is threefold. First, we gather a lung ultrasound (POCUS) dataset consisting of 1103 images (654 COVID-19, 277 bacterial pneumonia and 172 healthy controls), sampled from 64 videos. This dataset was assembled from various online sources, processed specifically for deep learning models and is intended to serve as a starting point for an open-access initiative. Second, we train a deep convolutional neural network (POCOVID-Net) on this 3-class dataset and achieve an accuracy of 89% and, by a majority vote, a video accuracy of 92% . For detecting COVID-19 in particu
The claims made in a manifesto resulting in the European quantum technologies flagship initiative in quantum technology and similar enterprises are taken as starting point to critically review some potential quantum resources, such as coherent superposition and entanglement, and their potential usefulness for parallelism and communication. Claims of absolute, irreducible (non-epistemic) randomness are argued to be metaphysical. Cryptanalytic man-in-the-middle attacks on quantum cryptography are well known to be feasible, but hardly mentioned. If all of this is taken into account, a more sober perspective on quantum capacities emerges, but one that may be ethically more justified than the "hype and magic" that drives many current initiatives.
Purpose: We aim to enhance the image quality of point-of-care ultrasound (POCUS) devices using deep learning and a novel paired dataset of POCUS and high-end ultrasound images. Approach: We collected the first accurately paired dataset using a custom-built automated gantry system of low-end POCUS and high-end ultrasound images. A conditional generative adversarial network (cGAN) was utilized based on the pix2pix architecture, with a U-Net generator that incorporates both L1 and structural similarity index (SSIM) losses to improve perceptual quality. Pretraining on a simulation dataset further boosts performance. Evaluation was performed on 1064 paired ex vivo tissue and phantom ultrasound image sets. Results: Our approach improves the SSIM from 0.29 to 0.54 and PSNR from 19.16 dB to 22.41 dB. No-reference metrics also indicate substantial enhancement, with the Natural Image Quality Evaluator (NIQE) and Perception-based Image Quality Evaluator (PIQE) scores dropping from 7.95 to 4.44 and 31.12 to 19.99, respectively. Conclusions: This work presents the first publicly available accurately paired dataset of low-end POCUS to high end ultrasound images. Additionally, our results demonst
It is often desirable to generalize medical imaging AI models trained with dense annotations to data acquired from different ultrasound scanners or clinical sites; however, retraining these models with new annotations is often difficult and costly. We examine this challenge in pediatric wrist fracture assessment using point-of-care ultrasound (POCUS), where fractures are common and can be effectively triaged via ultrasound. AI has shown radiologist-level performance for fracture detection, often aided by high-quality bony structure segmentation. However, due to significant domain shifts, models perform poorly on data from other centers or probes, and obtaining segmentation labels across devices is impractical due to manual annotation effort and data privacy concerns. To address this, we propose a target-informed self-supervised pretraining and model-ensemble strategy. Specifically, our approach combines masked image modeling (MIM) and contrastive learning to learn target-domain structural representations without labels, and introduces a confidence-aware infusion head to adaptively integrate predictions. The source dataset, collected with a Philips Lumify probe, contained dense labe
Objective: To develop a robust and compact deep learning model for automated knee cartilage segmentation on point-of-care ultrasound (POCUS) devices. Methods: We propose MonoUNet, a novel, highly compact segmentation model consisting of (i) an aggressively reduced U-Net backbone, (ii) a trainable monogenic block that extracts multi-scale local phase features from the input, and (iii) a gating mechanism that injects these features into the encoder stages to reduce sensitivity to variations in ultrasound image appearance. MonoUNet segmentation performance was evaluated on a multi-site, multi-device knee cartilage ultrasound dataset using Dice score and mean average surface distance (MASD). Agreement between MonoUNet and manual cartilage outcomes (thickness and echo intensity) was assessed using Bland-Altman analysis with 95% limits of agreement, and reliability was assessed using intraclass correlation coefficient (ICC$_{2,k}$). Results: Overall, MonoUNet outperformed existing lightweight segmentation models, with average Dice scores ranging from 92.62% to 94.82% and MASD values between 0.133 mm and 0.254 mm. MonoUNet reduces the number of parameters by 10x--700x and computational co
Purpose: Echocardiography with point-of-care ultrasound (POCUS) must support clinical decision-making under tight bedside time and operator-effort constraints. We introduce a personalized data acquisition strategy in which an RL agent, given a partially observed multi-view study, selects the next view to acquire or terminates acquisition to support heart-failure (HF) assessment. Upon termination, a diagnostic model jointly predicts aortic stenosis (AS) severity and left ventricular ejection fraction (LVEF), two key HF biomarkers, and outputs uncertainty, enabling an explicit trade-off between diagnostic performance and acquisition cost. Methods: We model POCUS as a sequential acquisition problem: at each step, a video selector (RL agent) chooses the next view to acquire or terminates acquisition. Upon termination, a shared multi-view transformer performs multi-task inference with two heads, ordinal AS classification, and LVEF regression, and outputs Gaussian predictive distributions yielding ordinal probabilities over AS classes and EF thresholds. These probabilities drive a reward that balances expected diagnostic benefit against acquisition cost, producing patient-specific acquis
Hospital readmission within 30 days of discharge is a leading driver of morbidity, mortality, and avoidable healthcare expenditure in congestive heart failure (CHF). Current clinical risk stratification tools rely primarily on non-imaging data and exhibit limited predictive performance. Point-of-care lung ultrasound (LUS) offers a sensitive, noninvasive window into the pulmonary congestion that characterizes CHF decompensation, yet its prognostic utility for readmission prediction remains largely unexplored. We present a pilot feasibility study, the first systematic machine learning study using B-mode LUS acquired during hospitalization to predict 30-day CHF readmission. Quantitative spatiotemporal embeddings are extracted from a pretrained Temporal Shift Module (TSM) ResNet-18 encoder, and interpretable biomarker features are separately evaluated. Through structured ablations over lung view, temporal representation, multi-view fusion, and cross-lung augmentation, we identify the key imaging factors driving readmission risk. Our findings reveal that (1) dependent lower-lung regions (Left-3, Right-3) carry the strongest prognostic signal, consistent with their greater susceptibility
Objective To develop a robust and computationally efficient deep learning model for automated left ventricular ejection fraction (LVEF) estimation from echocardiography videos that is suitable for real-time point-of-care ultrasound (POCUS) deployment. Methods We propose Echo-E$^3$Net, an endocardial spatio-temporal network that explicitly incorporates cardiac anatomy into LVEF prediction. The model comprises a dual-phase Endocardial Border Detector (E$^2$CBD) that uses phase-specific cross attention to localize end-diastolic and end-systolic endocardial landmarks and to learn phase-aware landmark embeddings, and an Endocardial Feature Aggregator (E$^2$FA) that fuses these embeddings with global statistical descriptors of deep feature maps to refine EF regression. Training is guided by a multi-component loss inspired by Simpson's biplane method that jointly supervises EF and landmark geometry. We evaluate Echo-E$^3$Net on the EchoNet-Dynamic dataset using RMSE and R$^2$ while reporting parameter count and GFLOPs to characterize efficiency. Results On EchoNet-Dynamic, Echo-E$^3$Net achieves an RMSE of 5.20 and an R$^2$ score of 0.82 while using only 1.55M parameters and 8.05 GFLOPs.
Retinal detachment (RD) is a vision-threatening condition that requires prompt intervention to preserve sight. A critical factor in treatment urgency and visual prognosis is macular involvement -- whether the macula is intact or detached. Point-of-care ultrasound (POCUS) is a fast, non-invasive and cost-effective imaging tool commonly used to detect RD in various clinical settings. However, its diagnostic utility is limited by the need for expert interpretation, especially in resource-limited environments. Deep learning has the potential to automate RD detection on ultrasound, but there are no clinically available models, and prior research has not addressed macular status -- an essential distinction for surgical prioritization. Additionally, no public dataset currently supports macular-based RD classification using ultrasound video. We introduce Eye Retinal DEtachment ultraSound (ERDES), the first open-access dataset of ocular ultrasound clips labeled for (i) presence of RD and (ii) macula-detached vs. macula-intact status. ERDES enables machine learning development for RD detection. We also provide baseline benchmarks by training 40 models across eight architectures, including 3D
Synthetic data generation represents a significant advancement in boosting the performance of machine learning (ML) models, particularly in fields where data acquisition is challenging, such as echocardiography. The acquisition and labeling of echocardiograms (echo) for heart assessment, crucial in point-of-care ultrasound (POCUS) settings, often encounter limitations due to the restricted number of echo views available, typically captured by operators with varying levels of experience. This study proposes a novel approach for enhancing clinical diagnosis accuracy by synthetically generating echo views. These views are conditioned on existing, real views of the heart, focusing specifically on the estimation of ejection fraction (EF), a critical parameter traditionally measured from biplane apical views. By integrating a conditional generative model, we demonstrate an improvement in EF estimation accuracy, providing a comparative analysis with traditional methods. Preliminary results indicate that our synthetic echoes, when used to augment existing datasets, not only enhance EF estimation but also show potential in advancing the development of more robust, accurate, and clinically r
Aortic stenosis (AS) is a life-threatening condition caused by a narrowing of the aortic valve, leading to impaired blood flow. Despite its high prevalence, access to echocardiography (echo), the gold-standard diagnostic tool, is often limited due to resource constraints, particularly in rural and underserved areas. Point-of-care ultrasound (POCUS) offers a more accessible alternative but is restricted by operator expertise and the challenge of selecting the most relevant imaging views. To address this, we propose a reinforcement learning (RL)-driven active video acquisition framework that dynamically selects each patient's most informative echo videos. Unlike traditional methods that rely on a fixed set of videos, our approach continuously evaluates whether additional imaging is needed, optimizing both accuracy and efficiency. Tested on data from 2,572 patients, our method achieves 80.6% classification accuracy while using only 47% of the echo videos compared to a full acquisition. These results demonstrate the potential of active feature acquisition to enhance AS diagnosis, making echocardiographic assessments more efficient, scalable, and personalized. Our source code is availab
Point-of-Care Ultrasound (POCUS) is the practice of clinicians conducting and interpreting ultrasound scans right at the patient's bedside. However, the expertise needed to interpret these images is considerable and may not always be present in emergency situations. This reality makes algorithms such as machine learning classifiers extremely valuable to augment human decisions. POCUS devices are becoming available at a reasonable cost in the size of a mobile phone. The challenge of turning POCUS devices into life-saving tools is that interpretation of ultrasound images requires specialist training and experience. Unfortunately, the difficulty to obtain positive training images represents an important obstacle to building efficient and accurate classifiers. Hence, the problem we try to investigate is how to explore strategies to increase accuracy of classifiers trained with scarce data. We hypothesize that training with a few data instances may not suffice for classifiers to generalize causing them to overfit. Our approach uses an Explainable AI-Augmented approach to help the algorithm learn more from less and potentially help the classifier better generalize.
Pocket-sized, low-cost point-of-care ultrasound (POCUS) devices are increasingly used in musculoskeletal (MSK) applications for structural examination of bone tissue. However, the image quality in MSK ultrasound is often limited by speckle noise, low resolution, poor contrast, and anisotropic reflections, making bone images difficult to interpret without additional post-processing. Typically, medical ultrasound systems use delay and sum beamforming (DASB) for image reconstruction, which is not specifically optimized for bone structures. To address these limitations, we propose BEAM-Net, a novel end-to-end deep neural network (DNN) that performs high-frame-rate ultrasound beamforming with integrated bone enhancement, using single-plane-wave (SPW) radio frequency (RF) data as input. Our approach embeds a Bone Probability Map (BPM), which acts as an attention mechanism to enforce higher structural similarity around bony regions in the image. The proposed approach is the first of its kind to incorporate bone enhancement directly into ultrasound beamforming using deep learning. BEAM-Net was trained and evaluated on in-vivo MSK and synthetic RF ultrasound datasets. This paper introduces
Access to obstetric ultrasound is often limited in low-resource settings, particularly in rural areas of low- and middle-income countries. This work proposes a human-in-the-loop artificial intelligence (AI) system designed to assist midwives in acquiring diagnostically relevant fetal images using blind sweep protocols. The system incorporates a classification model along with a web-based platform for asynchronous specialist reviews. By identifying key frames in blind sweep studies, the AI system allows specialists to concentrate on interpretation rather than having to review entire videos. To evaluate its performance, blind sweep videos captured by a small group of soft-trained midwives using a low-cost Point-of-Care Ultrasound (POCUS) device were analyzed. The system demonstrated promising results in identifying standard fetal planes from sweeps made by non-experts. A field evaluation indicated good usability and a low cognitive workload, suggesting that it has the potential to expand access to prenatal imaging in underserved regions.
Ultrasound (US) machines display images on a built-in monitor, but routine transfer to hospital systems relies on DICOM. We propose a fully automatic method to generate labeled data that can be used to train a screen detector model, and a pipeline to use that model to extract and rectify the US image from a photograph of the monitor, without any need for human annotation. This removes the DICOM bottleneck and enables rapid testing and prototyping of new algorithms. In a proof-of-concept study, the rectified images retained enough visual fidelity to classify cardiac views with a balanced accuracy of 0.79 with respect to the native DICOMs., the rectified images retained enough visual fidelity to classify cardiac views with a balanced accuracy of 0.79 with respect to the native DICOMs.
Self-supervised learning (SSL) is one strategy for addressing the paucity of labelled data in medical imaging by learning representations from unlabelled images. Contrastive and non-contrastive SSL methods produce learned representations that are similar for pairs of related images. Such pairs are commonly constructed by randomly distorting the same image twice. The videographic nature of ultrasound offers flexibility for defining the similarity relationship between pairs of images. In this study, we investigated the effect of utilizing proximal, distinct images from the same B-mode ultrasound video as pairs for SSL. Additionally, we introduced a sample weighting scheme that increases the weight of closer image pairs and demonstrated how it can be integrated into SSL objectives. Named Intra-Video Positive Pairs (IVPP), the method surpassed previous ultrasound-specific contrastive learning methods' average test accuracy on COVID-19 classification with the POCUS dataset by $\ge 1.3\%$. Detailed investigations of IVPP's hyperparameters revealed that some combinations of IVPP hyperparameters can lead to improved or worsened performance, depending on the downstream task. Guidelines for
As the global population continues to face significant negative impact by the on-going COVID-19 pandemic, there has been an increasing usage of point-of-care ultrasound (POCUS) imaging as a low-cost and effective imaging modality of choice in the COVID-19 clinical workflow. A major barrier with widespread adoption of POCUS in the COVID-19 clinical workflow is the scarcity of expert clinicians that can interpret POCUS examinations, leading to considerable interest in deep learning-driven clinical decision support systems to tackle this challenge. A major challenge to building deep neural networks for COVID-19 screening using POCUS is the heterogeneity in the types of probes used to capture ultrasound images (e.g., convex vs. linear probes), which can lead to very different visual appearances. In this study, we explore the impact of leveraging extended linear-convex ultrasound augmentation learning on producing enhanced deep neural networks for COVID-19 assessment, where we conduct data augmentation on convex probe data alongside linear probe data that have been transformed to better resemble convex probe data. Experimental results using an efficient deep columnar anti-aliased convol
As the Coronavirus Disease 2019 (COVID-19) continues to impact many aspects of life and the global healthcare systems, the adoption of rapid and effective screening methods to prevent further spread of the virus and lessen the burden on healthcare providers is a necessity. As a cheap and widely accessible medical image modality, point-of-care ultrasound (POCUS) imaging allows radiologists to identify symptoms and assess severity through visual inspection of the chest ultrasound images. Combined with the recent advancements in computer science, applications of deep learning techniques in medical image analysis have shown promising results, demonstrating that artificial intelligence-based solutions can accelerate the diagnosis of COVID-19 and lower the burden on healthcare professionals. However, the lack of a huge amount of well-annotated data poses a challenge in building effective deep neural networks in the case of novel diseases and pandemics. Motivated by this, we present COVID-Net USPro, an explainable few-shot deep prototypical network, that monitors and detects COVID-19 positive cases with high precision and recall from minimal ultrasound images. COVID-Net USPro achieves 99.
Objective: Lung ultrasonography is a significant advance toward a harmless lung imagery system. This work has investigated the automatic localization of diagnostically significant features in lung ultrasound pictures which are Pleural line, A-lines, and B-lines. Study Design: Wavelet and Radon transforms have been utilized in order to denoise and highlight the presence of clinically significant patterns. The proposed framework is developed and validated using three different lung ultrasound image datasets. Two of them contain synthetic data and the other one is taken from the publicly available POCUS dataset. The efficiency of the proposed method is evaluated using 200 real images. Results: The obtained results prove that the comparison between localized patterns and the baselines yields a promising F2-score of 62%, 86%, and 100% for B-lines, A-lines, and Pleural line, respectively. Conclusion: Finally, the high F-scores attained show that the developed technique is an effective way to automatically extract lung patterns from ultrasound images.