Oral diseases such as periodontal (gum) diseases and dental caries (cavities) affect billions of people across the world today. However, previous state-of-the-art models have relied on X-ray images to detect oral diseases, making them inaccessible to remote monitoring, developing countries, and telemedicine. To combat this overuse of X-ray imagery, we propose a lightweight machine learning model capable of detecting calculus (also known as hardened plaque or tartar) in RGB images while running efficiently on low-end devices. The model, a modified MobileNetV3-Small neural network transfer learned from ImageNet, achieved an accuracy of 72.73% (which is comparable to state-of-the-art solutions) while still being able to run on mobile devices due to its reduced memory requirements and processing times. A ResNet34-based model was also constructed and achieved an accuracy of 81.82%. Both of these models were tested on a mobile app, demonstrating their potential to limit the number of serious oral disease cases as their predictions can help patients schedule appointments earlier without the need to go to the clinic.
Oral mucosal diseases such as leukoplakia, oral lichen planus, and recurrent aphthous ulcers exhibit diverse and overlapping visual features, making diagnosis challenging for non-specialists. While vision-language models (VLMs) have shown promise in medical image interpretation, their application in oral healthcare remains underexplored due to the lack of large-scale, well-annotated datasets. In this work, we present \textbf{OralGPT}, the first domain-specific two-stage vision-language framework designed for oral mucosal disease diagnosis and captioning. In Stage 1, OralGPT learns visual representations and disease-related concepts from classification labels. In Stage 2, it enhances its language generation ability using long-form expert-authored captions. To overcome the annotation bottleneck, we propose a novel similarity-guided data augmentation strategy that propagates descriptive knowledge from expert-labeled images to weakly labeled ones. We also construct the first benchmark dataset for oral mucosal diseases, integrating multi-source image data with both structured and unstructured textual annotations. Experimental results on four common oral conditions demonstrate that OralG
In this work, we focused on deep learning image processing in the context of oral rare diseases, which pose challenges due to limited data availability. A crucial step involves teeth detection, segmentation and numbering in panoramic radiographs. To this end, we used a dataset consisting of 156 panoramic radiographs from individuals with rare oral diseases and labeled by experts. We trained the Detection Transformer (DETR) neural network for teeth detection, segmentation, and numbering the 52 teeth classes. In addition, we used data augmentation techniques, including geometric transformations. Finally, we generated new panoramic images using inpainting techniques with stable diffusion, by removing teeth from a panoramic radiograph and integrating teeth into it. The results showed a mAP exceeding 0,69 for DETR without data augmentation. The mAP was improved to 0,82 when data augmentation techniques are used. Furthermore, we observed promising performances when using new panoramic radiographs generated with inpainting technique, with mAP of 0,76.
Univariate zero-inflated models are increasingly being used to account for excess zeros in spatio-temporal infectious disease counts. However, the multivariate case is challenging due to the need to account for correlations across space, time and disease in both the count and zero-inflated components of the model. We are interested in comparing the transmission dynamics of several co-circulating infectious diseases across space and time, where some of the diseases can be absent for long periods. We first assume there is a baseline disease that is well-established and always present in the region. The other diseases switch between periods of presence and absence in each area through a series of coupled Markov chains, which account for long periods of disease absence, disease interactions and disease spread from neighboring areas. Since we are mainly interested in comparing the diseases, we assume the cases of the present diseases in an area jointly follow an autoregressive multinomial model. We use the multinomial model to investigate whether there are associations between certain factors, such as temperature, and differences in the transmission intensity of the diseases. Inference
Early detection of oral cancer and potentially malignant diseases is a major challenge in low-resource settings due to the scarcity of annotated data. We provide a unified approach for four-class oral lesion classification that incorporates deep learning, spectral analysis, and demographic data. A pathologist-verified subset of oral cavity images was curated from a publicly available dataset. Oral cavity pictures were processed using a fine-tuned ConvNeXt-v2 network for deep embeddings before being translated into the hyperspectral domain using a reconstruction algorithm. Haemoglobin-sensitive, textural, and spectral descriptors were obtained from the reconstructed hyperspectral cubes and combined with demographic data. Multiple machine-learning models were evaluated using patient-specific validation. Finally, an incremental heuristic meta-learner (IHML) was developed that merged calibrated base classifiers via probabilistic feature stacking and uncertainty-aware abstraction of multimodal representations with patient-level smoothing. By decoupling evidence extraction from decision fusion, IHML stabilizes predictions in heterogeneous, small-sample medical datasets. On an unseen test
Oral cancer constitutes a significant global health concern, resulting in 277,484 fatalities in 2023, with the highest prevalence observed in low- and middle-income nations. Facilitating automation in the detection of possibly malignant and malignant lesions in the oral cavity could result in cost-effective and early disease diagnosis. Establishing an extensive repository of meticulously annotated oral lesions is essential. In this research photos are being collected from global clinical experts, who have been equipped with an annotation tool to generate comprehensive labelling. This research presents a novel approach for integrating bounding box annotations from various doctors. Additionally, Deep Belief Network combined with CAPSNET is employed to develop automated systems that extracted intricate patterns to address this challenging problem. This study evaluated two deep learning-based computer vision methodologies for the automated detection and classification of oral lesions to facilitate the early detection of oral cancer: image classification utilizing CAPSNET. Image classification attained an F1 score of 94.23% for detecting photos with lesions 93.46% for identifying images
Oral cancer presents a formidable challenge in oncology, necessitating early diagnosis and accurate prognosis to enhance patient survival rates. Recent advancements in machine learning and data mining have revolutionized traditional diagnostic methodologies, providing sophisticated and automated tools for differentiating between benign and malignant oral lesions. This study presents a comprehensive review of cutting-edge data mining methodologies, including Neural Networks, K-Nearest Neighbors (KNN), Support Vector Machines (SVM), and ensemble learning techniques, specifically applied to the diagnosis and prognosis of oral cancer. Through a rigorous comparative analysis, our findings reveal that Neural Networks surpass other models, achieving an impressive classification accuracy of 93,6 % in predicting oral cancer. Furthermore, we underscore the potential benefits of integrating feature selection and dimensionality reduction techniques to enhance model performance. These insights underscore the significant promise of advanced data mining techniques in bolstering early detection, optimizing treatment strategies, and ultimately improving patient outcomes in the realm of oral oncolog
Cytology is a valuable tool for early detection of oral squamous cell carcinoma (OSCC). However, manual examination of cytology whole slide images (WSIs) is slow, subjective, and depends heavily on expert pathologists. To address this, we introduce the first weakly supervised deep learning framework for patient-level diagnosis of oral cytology whole slide images, leveraging the newly released Oral Cytology Dataset [1], which provides annotated cytology WSIs from ten medical centres across India. Each patient case is represented as a bag of cytology patches and assigned a diagnosis label (Healthy, Benign, Oral Potentially Malignant Disorders (OPMD), OSCC) by an in-house expert pathologist. These patient-level weak labels form a new extension to the dataset. We evaluate a baseline multiple-instance learning (MIL) model and a proposed Region-Affinity Attention MIL (RAA-MIL) that models spatial relationships between regions within each slide. The RAA-MIL achieves an average accuracy of 72.7%, weighted F1-score of 0.69 on an unseen test set, outperforming the baseline. This study establishes the first patient-level weakly supervised benchmark for oral cytology and moves toward reliable
Dental disease is a prevalent chronic condition associated with substantial financial burden, personal suffering, and increased risk of systemic diseases. Despite widespread recommendations for twice-daily tooth brushing, adherence to recommended oral self-care behaviors remains sub-optimal due to factors such as forgetfulness and disengagement. To address this, we developed Oralytics, a mHealth intervention system designed to complement clinician-delivered preventative care for marginalized individuals at risk for dental disease. Oralytics incorporates an online reinforcement learning algorithm to determine optimal times to deliver intervention prompts that encourage oral self-care behaviors. We have deployed Oralytics in a registered clinical trial. The deployment required careful design to manage challenges specific to the clinical trials setting in the U.S. In this paper, we (1) highlight key design decisions of the RL algorithm that address these challenges and (2) conduct a re-sampling analysis to evaluate algorithm design decisions. A second phase (randomized control trial) of Oralytics is planned to start in spring 2025.
The diagnosis of oral diseases presents a problematic clinical challenge, characterized by a wide spectrum of pathologies with overlapping symptomatology. To address this, we developed Clinical Semantic Intelligence (CSI), a novel artificial intelligence framework that diagnoses 118 different oral diseases by computationally modeling the cognitive processes of an expert clinician. Our core hypothesis is that moving beyond simple pattern matching to emulate expert reasoning is critical to building clinically useful diagnostic aids. CSI's architecture integrates a fine-tuned multimodal CLIP model with a specialized ChatGLM-6B language model. This system executes a Hierarchical Diagnostic Reasoning Tree (HDRT), a structured framework that distills the systematic, multi-step logic of differential diagnosis. The framework operates in two modes: a Fast Mode for rapid screening and a Standard Mode that leverages the full HDRT for an interactive and in-depth diagnostic workup. To train and validate our system, we curated a primary dataset of 4,310 images, supplemented by an external hold-out set of 176 images for final validation. A clinically-informed augmentation strategy expanded our tr
Periodontal diseases, reportedly affect 4 out of 10 adults in the USA. The standard of care for clinical assessments of these diseases is invasive, subjective and semi-qualitative. Thus, research on proposing alternate noninvasive modalities for clinical assessments of periodontal tissues is crucial. Quantitative Ultrasound (QUS) has shown promises in noninvasive assessments of various diseases in soft biological tissues; however, it has not been employed in periodontology. Here as the first step, we focused on QUS-based characterization of two very adjacent oral soft tissues of alveolar mucosa and attached gingiva in an in vivo animal study. We investigated first order ultrasonic speckle statistics using the two-parameter Burr model (b and l). Our QUS analysis was compared with the Masson$'$s Trichrome histology images of the two oral tissue types quantitatively using the RGB color thresholding. QUS study included 10 swine and US scanning was performed at the first and second molars, resulting in 80 scans. US scan data was acquired at the frequency of 24 MHz. Results at both oral sites (molar 1 and molar 2) showed that difference between the two tissue types using Burr parameters
This study investigates the application of diffusion models in medical image classification (DiffMIC), focusing on skin and oral lesions. Utilizing the datasets PAD-UFES-20 for skin cancer and P-NDB-UFES for oral cancer, the diffusion model demonstrated competitive performance compared to state-of-the-art deep learning models like Convolutional Neural Networks (CNNs) and Transformers. Specifically, for the PAD-UFES-20 dataset, the model achieved a balanced accuracy of 0.6457 for six-class classification and 0.8357 for binary classification (cancer vs. non-cancer). For the P-NDB-UFES dataset, it attained a balanced accuracy of 0.9050. These results suggest that diffusion models are viable models for classifying medical images of skin and oral lesions. In addition, we investigate the robustness of the model trained on PAD-UFES-20 for skin cancer but tested on the clinical images of the HIBA dataset.
Accurate and early detection of oral cancer lesions is crucial for effective diagnosis and treatment. This study evaluates two RPA implementations, OC-RPAv1 and OC-RPAv2, using a test set of 31 images. OC-RPAv1 processes one image per prediction in an average of 0.29 seconds, while OCRPAv2 employs a Singleton design pattern and batch processing, reducing prediction time to just 0.06 seconds per image. This represents a 60-100x efficiency improvement over standard RPA methods, showcasing that design patterns and batch processing can enhance scalability and reduce costs in oral cancer detection
Oral examinations are a prevalent but psychologically demanding form of assessment in higher education. Many students experience intense anxiety, which can impair cognitive performance and hinder academic success. This position paper explores the potential of embodied conversational agents (ECAs) in extended reality (XR) environments to support students preparing for oral exams. We propose a system concept that integrates photorealistic ECAs with real-time capable large language models (LLMs) to enable psychologically safe, adaptive, and repeatable rehearsal of oral examination scenarios. We also discuss the potential benefits and challenges of such an envisioned system.
Oral cancer ranks among the most prevalent cancers globally, with a particularly high mortality rate in regions lacking adequate healthcare access. Early diagnosis is crucial for reducing mortality; however, challenges persist due to limited oral health programs, inadequate infrastructure, and a shortage of healthcare practitioners. Conventional deep learning models, while promising, often rely on point estimates, leading to overconfidence and reduced reliability. Critically, these models require large datasets to mitigate overfitting and ensure generalizability, an unrealistic demand in settings with limited training data. To address these issues, we propose a hybrid model that combines a convolutional neural network (CNN) with Bayesian deep learning for oral cancer classification using small training sets. This approach employs variational inference to enhance reliability through uncertainty quantification. The model was trained on photographic color images captured by smartphones and evaluated on three distinct test datasets. The proposed method achieved 94% accuracy on a test dataset with a distribution similar to that of the training data, comparable to traditional CNN perform
Due to a lack of medical resources or oral health awareness, oral diseases are often left unexamined and untreated, affecting a large population worldwide. With the advent of low-cost, sensor-equipped smartphones, mobile apps offer a promising possibility for promoting oral health. However, to the best of our knowledge, no mobile health (mHealth) solutions can directly support a user to self-examine their oral health condition. This paper presents OralCam, the first interactive app that enables end-users' self-examination of five common oral conditions (diseases or early disease signals) by taking smartphone photos of one's oral cavity. OralCam allows a user to annotate additional information (e.g. living habits, pain, and bleeding) to augment the input image, and presents the output hierarchically, probabilistically and with visual explanations to help a laymen user understand examination results. Developed on our in-house dataset that consists of 3,182 oral photos annotated by dental experts, our deep learning based framework achieved an average detection sensitivity of 0.787 over five conditions with high localization accuracy. In a week-long in-the-wild user study (N=18), most
English as a Foreign Language (EFL) students often struggle to deliver oral presentations due to a lack of reliable resources and the limited effectiveness of instructors' feedback. Large Language Model (LLM) can offer new possibilities to assist students' oral presentations with real-time feedback. This paper investigates how ChatGPT can be effectively integrated into EFL oral presentation practice to provide personalized feedback. We introduce a novel learning platform, CHOP (ChatGPT-based interactive platform for oral presentation practice), and evaluate its effectiveness with 13 EFL students. By collecting student-ChatGPT interaction data and expert assessments of the feedback quality, we identify the platform's strengths and weaknesses. We also analyze learners' perceptions and key design factors. Based on these insights, we suggest further development opportunities and design improvements for the education community.
The mouth, often regarded as a window to the internal state of the body, plays an important role in reflecting one's overall health. Poor oral hygiene has far-reaching consequences, contributing to severe conditions like heart disease, cancer, and diabetes, while inadequate care leads to discomfort, pain, and costly treatments. Federated Learning (FL) for object detection can be utilized for this use case due to the sensitivity of the oral image data of the patients. FL ensures data privacy by storing the images used for object detection on the local device and trains the model on the edge. The updated weights are federated to a central server where all the collected weights are updated via The Federated Averaging algorithm. Finally, we have developed a mobile app named OralH which provides user-friendly solutions, allowing people to conduct self-assessments through mouth scans and providing quick oral health insights. Upon detection of the issues, the application alerts the user about potential oral health concerns or diseases and provides details about dental clinics in the user's locality. Designed as a Progressive Web Application (PWA), the platform ensures ubiquitous access, c
Oral exams were common historically across academia, though their popularity has recently fallen. Many argue against them as an assessment technique because they are vulnerable to bias and subjectivity, difficult to administer, and impractical in large college classes. I present a method for administering oral examinations in upper-level courses that mitigates some of the disadvantages. This method creates a rigid question structure meant to assess student mastery of material, have a well-defined grading structure to standardize evaluation, and be administered a constrained time limit to reduce workload in larger seminars. I emphasize holistic verbal communication and evaluation that is meant to mirror the talks and interviews that are common throughout a scientist's career.
Objective: The aim of this study was to systematically evaluate and compare the performance of five state-of-the-art transformer-based architectures - Vision Transformer (ViT), Data-efficient Image Transformer (DeiT), ConvNeXt, Swin Transformer, and Bidirectional Encoder Representation from Image Transformers (BEiT) - for multi-class dental disease classification. The study specifically focused on addressing real-world challenges such as data imbalance, which is often overlooked in existing literature. Study Design: The Oral Diseases dataset was used to train and validate the selected models. Performance metrics, including validation accuracy, precision, recall, and F1-score, were measured, with special emphasis on how well each architecture managed imbalanced classes. Results: ConvNeXt achieved the highest validation accuracy at 81.06, followed by BEiT at 80.00 and Swin Transformer at 79.73, all demonstrating strong F1-scores. ViT and DeiT achieved accuracies of 79.37 and 78.79, respectively, but both struggled particularly with Caries-related classes. Conclusions: ConvNeXt, Swin Transformer, and BEiT showed reliable diagnostic performance, making them promising candidates for cli