Low health literacy is prevalent in both healthy and clinical populations, and plays a critical role in health behaviors and outcomes. The Newest Vital Sign (NVS) is a performance-based screening measure of health literacy that assesses numeracy, prose literacy, and document literacy. However, the underlying factor structure of the NVS is not well established and questions persist regarding optimal scoring methods, which limits our understanding of this widely-used measure. The current study therefore aimed to confirm the factor structure of the NVS in separate samples of healthy, English-speaking adults and people with HIV (PWH). The study samples consisted of English-speaking adults without HIV (n = 270) and PWH (n = 310) who completed the 6-item NVS. Confirmatory factor analysis was used to test one-, two-, and three-factor models for the items on the NVS. A five-item, single factor solution for the NVS provided the best fit to the data and showed configural invariance between the samples of healthy adults and PWH. Findings provide evidence for the construct validity of a revised, five-item scoring of the NVS in a clinical and non-clinical sample of English-speaking adults. Future research is needed to examine the psychometrics and construct validity of this revised NVS in other clinical populations. Results of this factor analytic study suggest that researchers and clinicians are well supported in using a single, five-item score from the NVS to assess health literacy in people with chronic medical conditions.
Low health literacy is common and can affect brain health behaviors, yet clinical neuropsychologists do not commonly assess this important construct. The Newest Vital Sign (NVS) is a performance-based health literacy screening instrument that might be of value to clinical neuropsychologists. The current study examined the possible effects of age on the NVS and its association with cognition and applied health literacy. Participants included 50 younger (18-32 years) and 41 middle-aged/older (51-82 years) healthy adults. All participants completed the NVS, a neuropsychological battery, and measures of applied health literacy, including web-based health search tasks and the Modified UCSD Brief Assessment for Capacity to Consent. Hypotheses were tested with multiple regression analyses covarying for oral word reading. Results showed that the middle-aged/older adults obtained mildly lower scores on the NVS as compared to younger adults. Lower NVS scores were moderately associated with cognition, particularly in the domain of executive functions (e.g. abstraction, flexibility, and generativity). Higher scores on the NVS were also moderately associated with better performance on measures of web-based health information searching and treatment appraisal. The NVS is associated with older age, executive functions, and applied health literacy. Clinical neuropsychologists might consider integrating the NVS into their batteries given its brevity and relevance to health factors that affect many people with central nervous system conditions.
Canine atopic dermatitis is a hereditary chronic inflammatory and pruritic skin disease, which is mediated by T cells and requires long-term, individualized management. In recent years, numerous studies have described a wide range of therapeutic approaches for canine atopic dermatitis, including fast-acting symptomatic treatments, long-term immune-modulating interventions, and strategies to support skin barrier function and microbial balance. This review summarizes the principal treatment modalities currently available, including glucocorticoids, cyclosporine A, mycophenolate, Janus kinase inhibitors, lokivetmab, and allergen-specific immunotherapy, as well as complementary strategies aimed at restoring skin barrier integrity. Emphasis is placed on the importance of a multimodal and personalized approach to optimize long-term disease control and improve quality of life in affected dogs. Providing an integrated overview of current evidence, this article aims to guide clinicians in making informed, evidence-based decisions and to support the safe and effective management of canine atopic dermatitis.
Patients with psoriasis treated with biologic therapy are considered to have increased risk of developing skin neoplasms. The impact of novel therapies on the development and biology of melanocytic lesions is not completely known. The aim of the study was assess if the treatment with biologics exerts effects on the melanocytic nevi. Dermoscopy and videodermoscopic imaging of 276 melanocytic lesions were performed at the initial visit and after one year in 13 patients with psoriasis treated with IL-12/23 inhibitors, IL-23 inhibitors or IL-17 inhibitors. The nevi size significantly increased at the one-year follow-up in the whole study group and in patients treated either with IL-23 inhibitors or IL-12/23 inhibitor. 2% of melanocytic nevi showed an increase in any of the scores (ABCD score, 7-Point Checklist score, CASH score) or at least 1-mm change in the diameter at the one-year follow-up; however, these changes were not statistically significant between the different therapy groups. Although treatment with novel groups of biologics leads to an increase in nevi size, it does not contribute to significant structural or color changes in melanocytic nevi or to the development of dysplastic nevi or melanoma at the one-year follow-up.
In 2026, the U.S. Food and Drug Administration introduced a new Risk Evaluation and Management Strategy (REMS) for the etonogestrel contraceptive implant. Although the intent was to maintain safe practices for device insertion and removal, the large body of long-standing safety data should raise questions about the need for these new requirements. In the absence of safety concerns regarding device insertion and removal, a REMS requirement on the etonogestrel contraceptive implant may lead to decreased reproductive health care access and provision.
Studies on drought stress physiology have primarily focused on the newest fully expanded leaves, in which drought reduces cytokinin (CTK) content, thereby disrupting water balance and photosynthesis. Mature (old) leaves usually exhibit greater sensitivity to drought than the newest fully expanded ones. However, the impact of higher endogenous CTK levels on photosynthetic rate (AN) and water use efficiency (WUE) in drought-stressed mature leaves remains underexplored. To address this, a drought experiment was performed using wild-type (WT) cotton and two CYTOKININ DEHYDROGENASE (GhCKX) suppression lines with elevated CTK levels. Here, suppressing GhCKX optimized the trade-off between AN and intrinsic WUE (iWUE) in mature leaves during drought, since not only higher AN but also higher iWUE were observed in transgenic lines than the WT under drought. This optimization was driven by shifts in the relationships of mesophyll conductance (gm) and maximum carboxylation rate (Vcmax) to stomatal conductance (gs), specifically higher gm/gs and Vcmax/gs ratios, resulting from larger enhancements in gm and Vcmax than in gs, caused by up-regulated CTK. Moreover, higher gm in drought-stressed transgenic lines than drought-stressed WT resulted from thinner cell wall, shorter distance between adjacent chloroplasts, and larger ratio of chloroplast area to mesophyll area facing the intercellular airspace; and their superior Vcmax was attributed to increased Rubisco content and initial Rubisco activity. This study reveals that promoting endogenous CTK simultaneously enhances AN and iWUE in mature leaves under drought via the coordination of photosynthetic constraints, offering a sustainable strategy to improve the drought resistance of crops.
Baffle leaks are a known complication of the atrial switch for D-looped transposition of the great arteries. A 46-year-old woman with D-looped transposition of the great arteries who underwent an atrial switch (Mustard) presented with a hemodynamically significant baffle leak in close proximity to the systemic tricuspid valve. This report details the first-in-human percutaneous closure of a large baffle leak using a newest generation closure device, the GORE CARDIOFORM ASD Occluder (GCA). Baffle leaks are traditionally managed with either surgery or percutaneously with catheter-based devices. The location of the leak in this case was close to the tricuspid valve, and so the newer, softer GCA device was used. This is the first-in-human percutaneous closure of a baffle leak after an atrial switch using the GCA device. The GCA is the newest generation of closure devices that may convey an advantage over previous technology when closing leaks adjacent to important cardiac structures.
We report the synthesis of a sulfated prism[5]arene macrocyclic host. The uncomplexed sulfated prism[5]arene exhibits broadened resonances at NMR concentrations (100 µM), but addition of acetone (0.6%) results in a diagnostic 1H NMR spectrum indicative of a D5-symmetry. Variable temperature fluorescence spectroscopy titrations performed at very low concentrations ([thionin] = 1.5 µM) allowed determination of the Ka (2.99 × 107 M-1) and ΔH (-2.60 kcal mol-1) values for the sulfated prism[5]arene•thionin complex. Subsequent competitive ITC experiments allowed determination of the thermodynamic parameters for complexation of sulfated prism[5]arene toward a 17-membered panel of hydrophobic (di)cationic guests. The sulfated prism[5]arene•methylated bipiperidine complex exhibits ultrahigh binding affinity with Ka exceeding 1012 M-1 in phosphate-buffered saline (PBS). We find that sulfated prism[5]arene preferentially complexes quaternary diammonium over the corresponding primary diammonium ions by factors up to 5136-fold, leading us to name it Prism[5]MaxQ. The sulfated prism[5]arene host binds more tightly than the carboxylated prism[5]arene host by factors up to 4300-fold, but is a less potent host than the sulfated pillar[6]arene by factors up to 88000-fold. Sulfated prism[5]arene is the newest member of the family of ultrahigh binding affinity hosts that is poised for application as a sequestrant for various compounds.
This study aims to assess the learning curves associated with pulsed Thulium laser enucleation of the prostate (ThuLEP) among three surgeons with varying levels of experience in Holmium laser enucleation of the prostate (HoLEP) as a treatment for lower urinary tract symptoms (LUTS) secondary to benign prostatic enlargement, with pulsed ThuLEP being one of the newest systems for the surgical treatment of male LUTS. We conducted a prospective analysis of the first 100 consecutive ThuLEP procedures performed by three surgeons with varying levels of HoLEP experience: one highly experienced (>1,000 prior HoLEP surgeries), one moderately experienced (>200 prior HoLEP surgeries), and one novice surgeon (with no prior HoLEP surgeries) undergoing a structured training program. The evaluation focused on perioperative characteristics, functional results, and safety outcomes. While postoperative functional outcomes were comparable across all groups, experienced surgeons demonstrated a steeper learning curve. The highly experienced surgeon achieved proficiency approximately twice as quickly as the moderately experienced one. Surgeons with prior HoLEP experience reached a performance plateau in enucleation efficiency (g/min) and enucleation time (min) roughly twice as quickly, while requiring only about half the laser energy (kJ). Training a HoLEP-inexperienced surgeon in ThuLEP proved both feasible and safe when conducted within a structured training program. Pulsed ThuLEP shows a learning curve comparable to HoLEP for inexperienced surgeons when performed following a structured training program. Switching lasers is safe and feasible for surgeons already experienced in HoLEP.
Background/Objectives: CLEC-2 (C-type lectin-like receptor 2), the newest discovered platelet receptor, is involved in platelet activation and aggregation, the inflammatory response, tumor growth, metastasis, and angiogenesis. These unique features make CLEC-2 a promising candidate for a new biomarker and therapeutic target. The aim of our study was to evaluate the diagnostic value of CLEC-2 in patients with colorectal cancer (CRC). Methods: The serum CLEC-2 concentration was determined using ELISA methods in 64 CRC patients and 25 healthy subjects. Results: Our results indicate that the concentration of the serum CLEC-2 was significantly higher in CRC patients than in healthy subjects. Furthermore, the CLEC-2 levels were significantly higher in G3- than G2-grade CRC, and in patients with more advanced CRC, such as those with lymph node and distant metastases, than in patients without any metastases. CLEC-2 showed a positive correlation with platelet indices (PLT and MPV). The area under the ROC curve confirmed CLEC-2's excellent diagnostic power in distinguishing between patients with CRC. Conclusions: Our results indicate that CLEC-2 may be associated with CRC development and suggest that the identification of this biomarker could be useful for determining CRC progression.
The European Association of Urology 2024-2025 guidelines recommend conservative management as first-line therapy for pediatric phimosis before considering surgical intervention. Balloon catheter dilation treatment (BCDT) has emerged as a promising foreskin-preserving approach, yet high-quality comparative evidence against conventional circumcision (CC) remains limited. This study aimed to compare the clinical efficacy, safety outcomes, and family-centered measures between BCDT and CC in a pediatric cohort. This retrospective cohort study enrolled 200 boys (aged 2-12 years) with Kikiros grade ≥ 2 phimosis treated between January and December 2024 at a tertiary pediatric surgery center. Patients were allocated to BCDT (n = 100) or CC (n = 100) groups based on treatment received. Primary outcomes included cure rates (Kikiros grade 0-1) at 6 months. Secondary outcomes encompassed procedure-related parameters, complication rates, pain assessment using the Face, Legs, Activity, Cry, Consolability (FLACC) scale, healing time, parent-reported satisfaction, and health literacy-associated compliance measures. Propensity score analysis confirmed baseline comparability. Number needed to treat (NNT) and effect sizes (Cohen's d) were calculated to quantify clinical significance. Both treatments achieved high 6-month cure rates (BCDT: 98.0% vs. CC: 100.0%; P = 0.497; absolute risk difference: 2.0%, 95% CI: -0.7% to 4.7%). BCDT demonstrated substantial advantages in procedure efficiency (mean operative time: 5.03 ± 0.62 vs. 29.38 ± 6.69 min; P < 0.001; Cohen's d=-5.13) and recovery parameters (healing time: 6.74 ± 2.13 vs. 15.90 ± 3.06 days; P < 0.001; Cohen's d=-3.47). Pain-related outcomes significantly favored BCDT: lower incidence (65.0% vs. 99.0%; P < 0.001; NNT = 3), shorter duration (21.2 ± 14.0 vs. 93.2 ± 55.6 h; P < 0.001), and reduced FLACC scores at 24 h (2.59 ± 1.44 vs. 5.22 ± 2.07; P < 0.001; Cohen's d=-1.48). Edema occurrence was substantially lower in the BCDT group (60.0% vs. 100.0%; P < 0.001; NNT = 2.5). Parent satisfaction rates (score 5, very satisfied) were 96.0% and 88.0% for BCDT and CC, respectively (P = 0.068). Parent health literacy (Newest Vital Sign score) positively correlated with home care compliance (r = 0.42; P < 0.001), with adequate literacy (NVS ≥ 4) associated with significantly better adherence (3.21 ± 0.58 vs. 2.74 ± 0.71; P < 0.001). In this retrospective cohort, BCDT achieved short-term (6-month) cure rates non-inferior to CC while offering clinically meaningful advantages in procedural simplicity (6-fold reduction in operative time), pain mitigation (34% absolute reduction in incidence), accelerated healing (2.4-fold faster), and enhanced parent satisfaction. As a foreskin-preserving, minimally invasive option requiring only topical anaesthesia, BCDT may be considered for carefully selected symptomatic children with pathological phimosis, within a stepwise conservative management strategy that includes watchful waiting and topical corticosteroids as first-line therapy. Routine intervention for asymptomatic physiological phimosis is not supported by these data, and durable cure, long-term recurrence prevention, and broad first-line adoption require confirmation in prospectively designed studies with follow-up extending beyond puberty. Outcomes are optimised when supported by adequate parent health literacy for post-procedure home-care adherence.
List-learning tasks (LLTs) are important for characterizing memory in Alzheimer's disease and related dementias. However, as the Uniform Data Set Neuropsychological Battery (UDS-NB) historically did not require a specific LLT, centers have administered different LLTs. The newest UDS version (v4.0) requires one of two LLTs. To support harmonized UDS memory research, we developed a memory composite incorporating UDS memory tests and multiple LLTs. Item-banking confirmatory factor analysis was applied to develop a memory composite in a diagnostically heterogeneous sample (n = 8716) that completed the UDS-NB and one of five LLTs. Construct validity was evaluated through associations with demographics, disease severity, cognitive tasks, brain volume, amyloid/tau PET positivity, and plasma phosphorylated tau. Analyses were replicated in a racially/ethnically diverse cohort (n = 839). Psychometric properties were adequate. Expected associations with demographics and clinical measures within development and validation cohorts supported validity. This composite supports memory research across cohorts that administer the UDS and LLTs. A user-friendly UI is freely available to create the score in other datasets.
The most common cancers in women, ovarian, cervical and endometrial, are still a significant cause of cancer-related illness and death around the world. Success with the newest immunotherapy can only be achieved when the treatment targets the tumor accurately. Although monoclonal antibodies, aptamers and antisense oligonucleotides are traditionally used in immunotargeting, they face challenges related to bulkiness, their price, immune response and reaching tumors. For these reasons, peptides are now considered important next-generation substances for immunotargeting. This review describes how peptides are becoming increasingly significant in gynecological oncology through their application in drug targeting, imaging cancer, and making vaccines. Findings on how peptide targeting systems measure up to other approaches and some recent advances in designing peptide-drug conjugates, receptor-targeting therapies, and CAR-T therapies are discussed. This review also discuss about how peptides are stable, how to deliver them selectively and how artificial intelligence supports better peptide designing. With the development of precision medicine, the use of peptide-based immunotargeting can greatly improve both the success and safety of treatments for cancer of the uterus and ovaries.
The accuracy of implant scans varies depending on the scanning technique used. Newest developments include the capability to capture implant positions by using tablet-based photogrammetry (PG). However, the accuracy of this scanning technique remains unknown. The purpose of this in vitro study was to analyze the accuracy of complete arch implant scans captured using a tablet-based PG and a noncalibrated implant scan body (ISB) system. A stone cast with 6 implant abutment analogs (MultiUnit Abutment Plus Replica) was digitized by using a laboratory scanner (T710) (control scan). Two groups were created depending on the scanning technique used to capture the experimental complete arch implant scans: tablet-based PG (T-Marker) (Tablet-PG group) and noncalibrated ISB system (IOConnect) (NC-ISB group) (n=30). In the Tablet-PG group, an optical marker was hand tightened into each implant abutment of the reference stone cast. Then, consecutive scans were captured by using a tablet (iPad Pro) and following the scanning distance and pattern recommended by the manufacturer. In the NC-ISB group, a noncalibrated ISB was hand tightened into each implant abutment toward the center of the arch, as instructed by the manufacturer. Consecutive scans involving the distal geometry of the noncalibrated ISBs were recorded using an IOS (Trios5). Euclidean linear and angular measurements were obtained on the control scan and used to compare the discrepancies with the same measurements obtained on each experimental scan. The independent samples t test was used to analyze the trueness data. The Levene test was used to analyze the precision values (α=.05). Significant differences were found among the overall linear (P<.001) and angular (P=.019) trueness discrepancies between the groups. The NC-ISB group had significantly better linear trueness but lower angular trueness than the Tablet-PG group. Additionally, significant angular (P<.001) precision discrepancies were found between the groups. The Tablet-PG group had significantly better angular precision than the NC-ISB group. Accuracy discrepancies were found among the scanning techniques tested. Nonetheless, the tablet-based PG and noncalibrated ISB system obtained accuracy values that may meet the clinical requirements for capturing implant positions.
This study characterized the analytical performance of the Tosoh Automated Glycohemoglobin Analyzer HLC-723GR01 (GR01), the newest-generation hemoglobin A1c (HbA1c) analyzer from Tosoh, relative to the predicate Tosoh HLC-723G8 glycohemoglobin analyzer (G8). Performance of the GR01 was assessed through precision, linearity, method comparison, and variant interference studies in whole blood and hemolysate. The G8 was the comparator method for all studies. Variant interference studies included specimens with heterozygous hemoglobin variants C, D, E, and S, as well as elevations of hemoglobin A2. Interference studies for elevated hemoglobin F were also conducted using cord blood. Total imprecision for the GR01 at HbA1c concentrations ranging from 5.0% to 12.0% (31-108 mmol/mol) was approximately 1% CV, meeting common acceptance limits applied to HbA1c clinical testing and method certification. Linearity studies also met acceptance criteria, with an average of 0.1% bias from the expected HbA1c concentration across the analytical measurement range. All paired GR01 and G8 HbA1c measurements in nonvariant specimens showed relative differences less than 5%; mean differences (in %HbA1c units) were 0.03% in whole blood (SD 0.07%) and 0.02% HbA1c in hemolysate (SD 0.07%). Across all variants, the mean difference between GR01 and G8 measurements was 0.1% (SD 0.25%). The GR01 showed excellent correlation with the predicate G8, including in specimens containing high concentrations of common heterozygous hemoglobin variants, exceeding variant levels of 30% to 40%. Relative bias between the methods near medical decision points of 6.5% and 8.0% (48 and 64 mmol/mol, respectively) achieved the ±5% criterion used by the National Glycohemoglobin Standardization Program.
As a staple food for half the world's population, rice is an important dietary source of magnesium (Mg), an essential mineral for human health. Enhanced Mg accumulation in rice grains has also been linked to eating quality. However, the mechanisms underlying Mg transport to the grains remains poorly understood. Here, we report that OsMGR2, a member belonging to Magnesium Release (MGR) family, is required for Mg accumulation in rice grains. OsMGR2 encodes a plasma membrane-localized transporter that mediates Mg efflux. OsMGR2 is constitutively and highly expressed in the stele tissues of roots, the phloem region of both enlarged and diffused vascular bundles in nodes, and the ovular vascular trace of caryopses. Knockout of this gene results in decreased root-to-shoot translocation and altered distribution of Mg to different organs; less Mg is allocated to the second newest leaf with high Mg requirement for active photosynthesis. The osmgr2 mutants exhibit decreased Mg accumulation in the grain, which are smaller, lighter, and shriveled, but show increased accumulation in the husk. The eating quality of the mutant grains is significantly decreased compared with the wild-type rice. These results indicate that OsMGR2 plays multiple roles within the rice; facilitating the root-to-shoot Mg translocation, mediating phloem-to-xylem Mg transfer at nodes for preferential distribution to the most active leaf, and exporting Mg from maternal vascular tissues of the caryopsis to the grains, processes essential for grain development and eating quality in rice.
United States labeling of the newest robotic surgical platform contraindicates the use of force feedback instruments during hysterectomy and myomectomy because of a theoretical, clinically unexamined bleeding risk. We describe real-world outcomes and quantified intraoperative force during continuous force feedback use throughout these procedures, including closure, in a setting where this restriction does not apply. This single-surgeon observational cohort comprised 93 consecutive patients undergoing robotic hysterectomy or myomectomy between December 2024 and April 2026, classified into 3 groups: force feedback active throughout (43), the same instruments with the feature disabled (13), and conventional instruments (37). The primary outcome was a composite of vaginal cuff dehiscence, uterine wound disruption, or readmission or reintervention for bleeding within 30 days. Baseline characteristics were comparable across groups. Mean intraoperative force in the active group was 2.1 newtons for hysterectomy and 2.2 newtons for myomectomy. The composite event occurred in 1 of 43 active-group patients (a readmission for bleeding) and in no patient in the other groups; no cuff dehiscence or uterine wound disruption occurred in any group. After adjustment for procedure, higher mean force was associated with shorter operative time. Continuous force feedback through the closure phases of robotic hysterectomy and myomectomy was not associated with cuff dehiscence or uterine wound disruption, and mean operative force clustered near 2 newtons. These hypothesis-generating findings warrant larger studies before safety equivalence can be inferred.
Various cervical disc prosthesis and implant designs for motion preservation are routinely used in cervical disc arthroplasty (CDA). One of the newest implant designs combines features of an articulating gliding surface with those of a viscoelastic flexible core. This should allow for absorption of compressive loads in the axial direction, whereas the gliding surface at the inner surface is intended to allow a physiological range of motion with a progressive increase of resistance in six degrees of freedom (DOF). The aim of this study was to evaluate the safety and efficacy of a new cervical disc prosthesis in a mono-centric clinical setting. This observational study analyzes the first clinical and radiological results over a period of up to 24 months and evaluates the safety and efficacy of the novel CDA design. Subjects with one- or two-level degenerative cervical disc disease were enrolled. Radiographic assessments were performed pre-operatively, as well as at the 12- and 24-month follow-ups. Clinical data including pain scores [visual analog scale (VAS), Denis Pain Scale, pharmacological treatment], function scores [Neck Disability Index (NDI), modified Japanese Orthopaedic Association (mJOA)], outcome scores (mMacnab) and complication rates were monitored. Forty-five subjects (21 male/24 female) with a mean age of 43.4 years (30-62 years) were operated on the levels C4/5 (7.0), C5/6 (22.0) and C6/7 (23.0) between 01/2021 and 01/2025. A total of 52 implants with sizes between 5 mm ×16 mm and 8 mm ×18 mm were used. Clinically, all subjects reported significant improvements in pain and functional outcomes; however, VAS arm improved better than VAS neck, whereas NDI and mJOA improved at all time points over baseline. No serious adverse events were monitored. Heterotopic ossification (McAfee grades 3 and 4) was observed in 17.3% after 2 years, subsidence with migration into the endplates >2 mm in 11.5%. There were no re-operations due to mechanical problems or implant malfunction. The clinically tested articulating and viscoelastic design concept demonstrated both safety and effectiveness for the treatment of degenerative cervical disc disease. Compared to baseline, all subjects demonstrated significantly improved quality of life and reduced pain, as well as a decreased need for analgesics.
Facelift surgery has evolved from superficial skin excisions to anatomically guided reconstruction of the deep facial and cervical layers. Modern deep-plane, extended deep-plane, and deep-neck techniques address the functional superficial muscular aponeurotic system (SMAS)-platysma unit, the retaining ligaments, and deep cervical structures. Preservation-based approaches, the crevasse technique, and recent endoscopic modalities emphasize structural integrity and natural vector repositioning. This article reviews the historical evolution of facelift, the anatomical principles, classical and contemporary techniques, and the newest modifications and emerging innovations, outlining future directions in cervicofacial rejuvenation. Das Facelifting hat sich von oberflächlichen Hautresektionen zu tiefen, anatomisch präzisen Rekonstruktionsverfahren entwickelt. Moderne Deep-Plane‑, Extended-Deep-Plane- und Deep-Neck-Techniken adressieren die funktionelle Einheit aus dem Komplex, der aus dem superfiziellen muskuloaponeurotischen System (SMAS) und dem Platysma besteht, den ligamentären Fixationspunkten und tiefen Halsstrukturen. Ergänzend haben „Preservation-Techniken“, die „Crevasse-Methode“ sowie endoskopische Zugänge eine neue Ära struktur- und funktionserhaltender Verfahren eingeleitet. Dieser Beitrag fasst die historische Entwicklung, anatomische Grundlagen, klassische und moderne Facelift-Techniken sowie die aktuellen Modifikationen zusammen und gibt einen Überblick über aktuelle Trends und zukünftige Perspektiven der zervikofazialen Rejuvenation.