Phosphorylation of IkappaB, an inhibitor of NF-kappaB, is an important step in the activation of the transcription factor NF-kappaB. Phosphorylation is mediated by the IkappaB kinase (IKK) complex, known to contain two catalytic subunits: IKKalpha and IKKbeta. A novel, noncatalytic component of this kinase complex called NEMO (NF-kappaB essential modulator)/IKKgamma was identified recently. We have generated NEMO/IKKgamma-deficient mice by gene targeting. Mutant embryos die at E12.5-E13.0 from severe liver damage due to apoptosis. NEMO/IKKgamma-deficient primary murine embryonic fibroblasts (MEFs) lack detectable NF-kappaB DNA-binding activity in response to TNFalpha, IL-1, LPS, and Poly(IC) and do not show stimulus-dependent IkappaB kinase activity, which correlates with a lack of phosphorylation and degradation of IkappaBalpha. Consistent with these data, mutant MEFs show increased sensitivity to TNFalpha-induced apoptosis. Our data provide in vivo evidence that NEMO/IKKgamma is the first essential, noncatalytic component of the IKK complex.
This paper introduces Nemo-Nemo, a practical crash-fault tolerant (CFT) consensus protocol designed to outperform existing protocols in wide-area networks by bridging design principles from the CFT and Byzantine-fault tolerant (BFT) worlds. By structuring command propagation through a causally ordered DAG, Nemo-Nemo allows all consensus replicas to propose commands with a naturally self-regulating communication regime. By exploiting multi-leader architecture, Nemo-Nemo avoids the performance bottleneck inherent to single-leader protocols. By separating command dissemination from consensus logic, Nemo-Nemo handles challenging network conditions even when consensus commits are stalled. Moreover, leader proposals that miss a deadline are never dropped, but deterministically deferred and executed later, preserving throughput under transient network delays. And by enabling Nemo-Nemo to commit on a DAG in just two network hops, it matches the latency of existing CFT systems, while achieving significantly higher throughput. The result is a robust, deployable system: the first DAG-based CFT consensus protocol proven to exceed state-of-the-art wide-area network performance in both speed and
We present the development and optimization of PayPal's Commerce Agent, powered by NEMO-4-PAYPAL, a multi-agent system designed to revolutionize agentic commerce on the PayPal platform. Through our strategic partnership with NVIDIA, we leveraged the NeMo Framework for LLM model fine-tuning to enhance agent performance. Specifically, we optimized the Search and Discovery agent by replacing our base model with a fine-tuned Nemotron small language model (SLM). We conducted comprehensive experiments using the llama3.1-nemotron-nano-8B-v1 architecture, training LoRA-based models through systematic hyperparameter sweeps across learning rates, optimizers (Adam, AdamW), cosine annealing schedules, and LoRA ranks. Our contributions include: (1) the first application of NVIDIA's NeMo Framework to commerce-specific agent optimization, (2) LLM powered fine-tuning strategy for retrieval-focused commerce tasks, (3) demonstration of significant improvements in latency and cost while maintaining agent quality, and (4) a scalable framework for multi-agent system optimization in production e-commerce environments. Our results demonstrate that the fine-tuned Nemotron SLM effectively resolves the key
We present NEMO, a system that translates Natural-language descriptions of decision problems into formal Executable Mathematical Optimization implementations using autonomous coding agents (ACAs). Existing approaches rely on specialized large language models (LLMs) or bespoke task-specific agents that are often brittle and frequently generate syntactically invalid or non-executable code. NEMO instead treats ACAs as a first-class abstraction analogous to API-based interaction with LLMs; their sandboxed execution guarantees code is executable by construction and supports automated validation and repair. We introduce novel coordination patterns including asymmetric validation loops between independently generated optimizer and simulator implementations, external memory for experience reuse, and robustness enhancements via minimum Bayes risk (MBR) decoding and self-consistency. Across nine established optimization benchmarks, NEMO achieves state-of-the-art performance on the majority of tasks with substantial margins on several datasets, demonstrating the power of execution-aware agentic architectures for automated optimization modeling.
We present Neural Memory Object (NeMO), a novel object-centric representation that can be used to detect, segment and estimate the 6DoF pose of objects unseen during training using RGB images. Our method consists of an encoder that requires only a few RGB template views depicting an object to generate a sparse object-like point cloud using a learned UDF containing semantic and geometric information. Next, a decoder takes the object encoding together with a query image to generate a variety of dense predictions. Through extensive experiments, we show that our method can be used for few-shot object perception without requiring any camera-specific parameters or retraining on target data. Our proposed concept of outsourcing object information in a NeMO and using a single network for multiple perception tasks enhances interaction with novel objects, improving scalability and efficiency by enabling quick object onboarding without retraining or extensive pre-processing. We report competitive and state-of-the-art results on various datasets and perception tasks of the BOP benchmark, demonstrating the versatility of our approach. https://github.com/DLR-RM/nemo
Following the design of more efficient blockchain consensus algorithms, the execution layer has emerged as the new performance bottleneck of blockchains, especially under high contention. Current parallel execution frameworks either rely on optimistic concurrency control (OCC) or on pessimistic concurrency control (PCC), both of which see their performance decrease when workloads are highly contended, albeit for different reasons. In this work, we present NEMO, a new blockchain execution engine that combines OCC with the object data model to address this challenge. NEMO introduces four core innovations: (i) a greedy commit rule for transactions using only owned objects; (ii) refined handling of dependencies to reduce re-executions; (iii) the use of incomplete but statically derivable read/write hints to guide execution; and (iv) a priority-based scheduler that favors transactions that unblock others. Through simulated execution experiments, we demonstrate that NEMO significantly reduces redundant computation and achieves higher throughput than representative approaches. For example, with 16 workers NEMO's throughput is up to 42% higher than the one of Block-STM, the state-of-the-ar
With the growing incorporation of deep neural network (DNN) models into modern software systems, the prohibitive construction costs have become a significant challenge. Model reuse has been widely applied to reduce training costs, but indiscriminately reusing entire models may incur significant inference overhead. Consequently, DNN modularization has gained attention, enabling module reuse by decomposing DNN models. The emerging modularizing-while-training (MwT) paradigm, which incorporates modularization into training, outperforms modularizing-after-training approaches. However, existing MwT methods focus on small-scale CNN models at the convolutional kernel level and struggle with diverse DNNs and large-scale models, particularly Transformer-based models. To address these limitations, we propose NeMo, a scalable and generalizable MwT approach. NeMo operates at the neuron level fundamental component common to all DNNs-ensuring applicability to Transformers and various architectures. We design a contrastive learning-based modular training method with an effective composite loss function, enabling scalability to large-scale models. Comprehensive experiments on two Transformer-based
We propose X-NeMo, a novel zero-shot diffusion-based portrait animation pipeline that animates a static portrait using facial movements from a driving video of a different individual. Our work first identifies the root causes of the key issues in prior approaches, such as identity leakage and difficulty in capturing subtle and extreme expressions. To address these challenges, we introduce a fully end-to-end training framework that distills a 1D identity-agnostic latent motion descriptor from driving image, effectively controlling motion through cross-attention during image generation. Our implicit motion descriptor captures expressive facial motion in fine detail, learned end-to-end from a diverse video dataset without reliance on pretrained motion detectors. We further enhance expressiveness and disentangle motion latents from identity cues by supervising their learning with a dual GAN decoder, alongside spatial and color augmentations. By embedding the driving motion into a 1D latent vector and controlling motion via cross-attention rather than additive spatial guidance, our design eliminates the transmission of spatial-aligned structural clues from the driving condition to the d
Multimodal Large Language Models (MLLMs) have made notable advances in visual understanding, yet their abilities to recognize objects modified by specific attributes remain an open question. To address this, we explore MLLMs' reasoning capabilities in object recognition, ranging from commonsense to beyond-commonsense scenarios. We introduce a novel benchmark, NEMO, which comprises 900 images of origiNal fruits and their corresponding attributE-MOdified ones; along with a set of 2,700 questions including open-, multiple-choice-, unsolvable types. We assess 26 recent open-sourced and commercial models using our benchmark. The findings highlight pronounced performance gaps in recognizing objects in NEMO and reveal distinct answer preferences across different models. Although stronger vision encoders improve performance, MLLMs still lag behind standalone vision encoders. Interestingly, scaling up the model size does not consistently yield better outcomes, as deeper analysis reveals that larger LLMs can weaken vision encoders during fine-tuning. These insights shed light on critical limitations in current MLLMs and suggest potential pathways toward developing more versatile and resilien
This system demonstration presents Nemo, a new logic programming engine with a focus on reliability and performance. Nemo is built for data-centric analytic computations, modelled in a fully declarative Datalog dialect. Its scalability for these tasks matches or exceeds that of leading Datalog systems. We demonstrate uses in reasoning with knowledge graphs and ontologies with 10^5 to 10^8 input facts, all on a laptop. Nemo is written in Rust and available as a free and open source tool.
Referring Image Segmentation is a comprehensive task to segment an object referred by a textual query from an image. In nature, the level of difficulty in this task is affected by the existence of similar objects and the complexity of the referring expression. Recent RIS models still show a significant performance gap between easy and hard scenarios. We pose that the bottleneck exists in the data, and propose a simple but powerful data augmentation method, Negative-mined Mosaic Augmentation (NeMo). This method augments a training image into a mosaic with three other negative images carefully curated by a pretrained multimodal alignment model, e.g., CLIP, to make the sample more challenging. We discover that it is critical to properly adjust the difficulty level, neither too ambiguous nor too trivial. The augmented training data encourages the RIS model to recognize subtle differences and relationships between similar visual entities and to concretely understand the whole expression to locate the right target better. Our approach shows consistent improvements on various datasets and models, verified by extensive experiments.
The 2.5-generation (2.5G) ground-based gravitational wave (GW) detectors LIGO Voyager and NEMO are expected to be operational in the late 2020s and early 2030s. In this work, we explore the potential of GW standard sirens observed by the 2.5G GW detectors in measuring cosmological parameters, especially for the Hubble constant. Using GWs to measure cosmological parameters is inherently challenging, especially for 2.5G detectors, given their limited capability, which results in weaker constraints on cosmological parameters from the detected standard sirens. However, the measurement of the Hubble constant using standard siren observations from Voyager and NEMO is still promising. For example, using bright sirens from Voyager and NEMO can measure the Hubble constant with a precision of about $2\%$ and $6\%$ respectively, and using the Voyager-NEMO network can improve the precision to about $1.6\%$. Moreover, bright sirens can be used to break the degeneracy of cosmological parameters generated by CMB data, and to a certain extent, 2.5G detectors can also play a role in this aspect. Observations of dark sirens by 2.5G detectors can achieve relatively good results in measuring the Hubbl
NeMo Guardrails is an open-source toolkit for easily adding programmable guardrails to LLM-based conversational systems. Guardrails (or rails for short) are a specific way of controlling the output of an LLM, such as not talking about topics considered harmful, following a predefined dialogue path, using a particular language style, and more. There are several mechanisms that allow LLM providers and developers to add guardrails that are embedded into a specific model at training, e.g. using model alignment. Differently, using a runtime inspired from dialogue management, NeMo Guardrails allows developers to add programmable rails to LLM applications - these are user-defined, independent of the underlying LLM, and interpretable. Our initial results show that the proposed approach can be used with several LLM providers to develop controllable and safe LLM applications using programmable rails.
We present the NVIDIA NeMo team's multi-channel speech recognition system for the 7th CHiME Challenge Distant Automatic Speech Recognition (DASR) Task, focusing on the development of a multi-channel, multi-speaker speech recognition system tailored to transcribe speech from distributed microphones and microphone arrays. The system predominantly comprises of the following integral modules: the Speaker Diarization Module, Multi-channel Audio Front-End Processing Module, and the ASR Module. These components collectively establish a cascading system, meticulously processing multi-channel and multi-speaker audio input. Moreover, this paper highlights the comprehensive optimization process that significantly enhanced our system's performance. Our team's submission is largely based on NeMo toolkits and will be publicly available.
NeMo (Neural Modules) is a Python framework-agnostic toolkit for creating AI applications through re-usability, abstraction, and composition. NeMo is built around neural modules, conceptual blocks of neural networks that take typed inputs and produce typed outputs. Such modules typically represent data layers, encoders, decoders, language models, loss functions, or methods of combining activations. NeMo makes it easy to combine and re-use these building blocks while providing a level of semantic correctness checking via its neural type system. The toolkit comes with extendable collections of pre-built modules for automatic speech recognition and natural language processing. Furthermore, NeMo provides built-in support for distributed training and mixed precision on latest NVIDIA GPUs. NeMo is open-source https://github.com/NVIDIA/NeMo
The NEMO 3 experiment is devoted to the search for neutrinoless double beta decay, as well as for accurate measurement of two-neutrino double beta decay. The detector has been taking data in the LSM laboratory since 2003 and the latest NEMO 3 results for seven double beta decay isotopes are presented here for both decay modes. The SuperNEMO project aims to extend the NEMO technique to a 100-200 kg isotope experiment with the target half-life sensitivity of 1-2 x 10^26 y. The current status of the SuperNEMO R&D programme is described.
The recent developments in space instrumentation for solar observations and telemetry have caused the necessity of advanced pattern recognition tools for the different classes of solar events. The Extreme ultraviolet Imaging Telescope (EIT) of solar corona on-board SOHO spacecraft has uncovered a new class of eruptive events which are often identified as signatures of Coronal Mass Ejection (CME) initiations on solar disk. It is evident that a crucial task is the development of an automatic detection tool of CMEs precursors. The Novel EIT wave Machine Observing (NEMO) (http://sidc.be/nemo) code is an operational tool that detects automatically solar eruptions using EIT image sequences. NEMO applies techniques based on the general statistical properties of the underlying physical mechanisms of eruptive events on the solar disc. In this work, the most recent updates of NEMO code - that have resulted to the increase of the recognition efficiency of solar eruptions linked to CMEs - are presented. These updates provide calculations of the surface of the dimming region, implement novel clustering technique for the dimmings and set new criteria to flag the eruptive dimmings based on their
The NEMO general circulation ocean model is extended to incorporate three physical processes related to ocean surface waves, namely the surface stress (modified by growth and dissipation of the oceanic wave field), the turbulent kinetic energy flux from breaking waves, and the Stokes-Coriolis force. Experiments are done with NEMO in ocean-only (forced) mode and coupled to the ECMWF atmospheric and wave models. Ocean-only integrations are forced with fields from the ERA-Interim reanalysis. All three effects are noticeable in the extra-tropics, but the sea-state dependent turbulent kinetic energy flux yields by far the largest difference. This is partly because the control run has too vigorous deep mixing due to an empirical mixing term in NEMO. We investigate the relation between this ad hoc mixing and Langmuir turbulence and find that it is much more effective than the Langmuir parameterization used in NEMO. The biases in sea surface temperature as well as subsurface temperature are reduced, and the total ocean heat content exhibits a trend closer to that observed in a recent ocean reanalysis (ORAS4) when wave effects are included. Seasonal integrations of the coupled atmosphere-wa
Network mobility basic support (NEMO BS) protocol (RFC 3963) is an extension of Mobile IPv6. The NEMO BS embraced by the IETF working group to permit any node in the portable network to be accessible to the Internet despite the fact the network itself is roaming. This protocol likewise Mobile IPv6 does not deliver any kind of Quality of Service (QoS) guarantees to its clients. It can barely offer the same level of services (i.e. Best-Effort) to all the users without obligation to the needs of applications. These propositions a challenge to real-time applications that demand a precise level of QoS pledge. The Differentiated Services have recently come to be the most widely used QoS support technology in IP networks due to its relative simplicity and scalability benefits. This paper proposes a new scheme to provide QoS to mobile network nodes within the NEMO context. The proposed scheme intends to reduce handover latency for the users of MNN as well as alleviates packet losses. The feasibility of the proposed enhancement is assessed by measuring its performance against the native NEMO BS standard protocol using the NS-2 simulator. The obtained results in the simulation study have dem
3D pose estimation is a challenging but important task in computer vision. In this work, we show that standard deep learning approaches to 3D pose estimation are not robust when objects are partially occluded or viewed from a previously unseen pose. Inspired by the robustness of generative vision models to partial occlusion, we propose to integrate deep neural networks with 3D generative representations of objects into a unified neural architecture that we term NeMo. In particular, NeMo learns a generative model of neural feature activations at each vertex on a dense 3D mesh. Using differentiable rendering we estimate the 3D object pose by minimizing the reconstruction error between NeMo and the feature representation of the target image. To avoid local optima in the reconstruction loss, we train the feature extractor to maximize the distance between the individual feature representations on the mesh using contrastive learning. Our extensive experiments on PASCAL3D+, occluded-PASCAL3D+ and ObjectNet3D show that NeMo is much more robust to partial occlusion and unseen pose compared to standard deep networks, while retaining competitive performance on regular data. Interestingly, our