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We investigate the consequences of periodic, on-off glucose infusion on the glucose-insulin regulatory system on the basis of a system-level mathematical model with two explicit time delays. Studying the effects of such infusion protocols is mathematically challenging yet a promising direction for probing the system response to infusion. We pay special attention to the interplay of the infusion with intermediate-time-scale, ultradian oscillations that arise as a results of the physiological response of glucose uptake and back-release into the bloodstream. By using numerical solvers and numerical continuation software, we investigate the response of the model to different infusion patterns, and explore how these patterns affect the overall levels of glucose and insulin, and can lead to entrainment. By doing so, we provide a road-map of system responses that can potentially help identify new test strategies for detecting abnormal responses to glucose uptake.
Data science has become increasingly essential for the production of official statistics, as it enables the automated collection, processing, and analysis of large amounts of data. With such data science practices in place, it enables more timely, more insightful and more flexible reporting. However, the quality and integrity of data-science-driven statistics rely on the accuracy and reliability of the data sources and the machine learning techniques that support them. In particular, changes in data sources are inevitable to occur and pose significant risks that are crucial to address in the context of machine learning for official statistics. This paper gives an overview of the main risks, liabilities, and uncertainties associated with changing data sources in the context of machine learning for official statistics. We provide a checklist of the most prevalent origins and causes of changing data sources; not only on a technical level but also regarding ownership, ethics, regulation, and public perception. Next, we highlight the repercussions of changing data sources on statistical reporting. These include technical effects such as concept drift, bias, availability, validity, accur
Publication patterns of 79 forest scientists awarded major international forestry prizes during 1990-2010 were compared with the journal classification and ranking promoted as part of the 'Excellence in Research for Australia' (ERA) by the Australian Research Council. The data revealed that these scientists exhibited an elite publication performance during the decade before and two decades following their first major award. An analysis of their 1703 articles in 431 journals revealed substantial differences between the journal choices of these elite scientists and the ERA classification and ranking of journals. Implications from these findings are that additional cross-classifications should be added for many journals, and there should be an adjustment to the ranking of several journals relevant to the ERA Field of Research classified as 0705 Forestry Sciences.
The City of Toronto Long Term Care Homes & Services (LTCH&S) division is one of the largest providers of long-term care in the Canadian province of Ontario, providing care to 2,640 residents at 10 homes across Toronto. Our collaboration with LTCH&S was initiated to facilitate the increasingly challenging task of scheduling nursing staff and reduce high absenteeism rate observed among the part-time nurses. We developed a spreadsheet-based scheduling tool to automate the generation of schedules and incorporate nurses' preferences for different shifts into the schedules. At the core of the scheduling tool is a hierarchical optimization model that generates a feasible schedule with the highest total preference score while satisfying the maximum possible demand. Feasible schedules had to abide by a set of complex seniority requirements which prioritized more senior nurses when allocating the available shifts. Our scheduling tool was implemented in a 391-bed home in Toronto. The tool allowed nursing managers to generate feasible schedules within a fraction of an hour, in contrast to the status-quo manual approach which could took up to tens of hours. In addition, the schedule
We report on the gamma-ray activity of the blazar Mrk 501 during the first 480 days of Fermi operation. We find that the average LAT gamma-ray spectrum of Mrk 501 can be well described by a single power-law function with a photon index of 1.78 +/- 0.03. While we observe relatively mild flux variations with the Fermi-LAT (within less than a factor of 2), we detect remarkable spectral variability where the hardest observed spectral index within the LAT energy range is 1.52 +/- 0.14, and the softest one is 2.51 +/- 0.20. These unexpected spectral changes do not correlate with the measured flux variations above 0.3GeV. In this paper, we also present the first results from the 4.5-month-long multifrequency campaign (2009 March 15 - August 1) on Mrk 501, which included the VLBA, Swift, RXTE, MAGIC and VERITAS, the F-GAMMA, GASP-WEBT, and other collaborations and instruments which provided excellent temporal and energy coverage of the source throughout the entire campaign. The average spectral energy distribution of Mrk 501 is well described by the standard one-zone synchrotron self-Compton model. In the framework of this model, we find that the dominant emission region is characterized b
The flexibility level allowed in nursing care delivery and uncertainty in infusion durations are very important factors to be considered during the chemotherapy schedule generation task. The nursing care delivery scheme employed in an outpatient chemotherapy clinic (OCC) determines the strictness of the patient-to-nurse assignment policies, while the estimation of infusion durations affects the trade-off between patient waiting time and nurse overtime. We study the problem of daily scheduling of patients, assignment of patients to nurses and chairs under uncertainty in infusion durations for an OCC that functions according to any of the three commonly used nursing care delivery models representing fully flexible, partially flexible, and inflexible care models, respectively. We develop a two-stage stochastic mixed-integer programming model that is valid for the three care delivery models to minimize expected weighted cost of patient waiting time and nurse overtime. We propose multiple variants of a scenario grouping-based decomposition algorithm to solve the model using data of a major university oncology hospital. The variants of the algorithm differ from each other according to th
A previous study of symmetric collisions of massive nuclei has shown that current models of multi-nucleon transfer (MNT) reactions do not adequately describe the transfer product yields. To gain further insight into this problem, we have measured the yields of MNT products in the interaction of 977 (E/A = 4.79 MeV) and 1143 MeV (E/A = 5.60 MeV) $^{204}$Hg with $^{208}$Pb. We find that the yield of multi-nucleon transfer products are similar in these two reactions and are substantially lower than those observed in the reaction of 1257 MeV (E/A = 6.16 MeV) $^{204}$Hg + $^{198}$Pt. We compare our measurements with the predictions of the GRAZING-F, di-nuclear systems (DNS) and improved quantum molecular dynamics (ImQMD) models. For the observed isotopes of the elements Au, Hg, Tl, Pb and Bi, the measured values of the MNT cross sections are orders of magnitude larger than the predicted values. Furthermore, the various models predict the formation of nuclides near the N=126 shell, which are not observed.
This paper explores the use of deep learning-based computer vision for real-time monitoring of the flow in intravenous (IV) infusions. IV infusions are among the most common therapies in hospitalized patients and, given that both over-infusion and under-infusion can cause severe damages, monitoring the flow rate of the fluid being administered to patients is very important for their safety. The proposed system uses a camera to film the IV drip infusion kit and a deep learning-based algorithm to classify acquired frames into two different states: frames with a drop that has just begun to take shape and frames with a well-formed drop. The alternation of these two states is used to count drops and derive a measurement of the flow rate of the drip. The usage of a camera as sensing element makes the proposed system safe in medical environments and easier to be integrated into current health facilities. Experimental results are reported in the paper that confirm the accuracy of the system and its capability to produce real-time estimates. The proposed method can be therefore effectively adopted to implement IV infusion monitoring and control systems.
Liquid resin infusion (LRI) processes are promising manufacturing routes to produce large, thick, or complex structural parts. They are based on the resin flow induced, across its thickness, by a pressure applied onto a preform/resin stacking. However, both thickness and fiber volume fraction of the final piece are not well controlled since they result from complex mechanisms which drive the transient mechanical equilibrium leading to the final geometrical configuration. In order to optimize both design and manufacturing parameters, but also to monitor the LRI process, an isothermal numerical model has been developed which describes the mechanical interaction between the deformations of the porous medium and the resin flow during infusion.1, 2 With this numerical model, it is possible to investigate the LRI process of classical industrial part shapes. To validate the numerical model, first in 2D, and to improve the knowledge of the LRI process, this study details a comparison between numerical simulations and an experimental study of a plate infusion test carried out by LRI process under industrial conditions. From the numerical prediction, the filling time, the resin mass and the
The aim of this report is to present a ranking of Nursing journals covered in Google Scholar Metrics (GSM), a Google product launched in 2012 to assess the impact of scientific journals from citation counts this receive on Google Scholar. Google has chosen to include only those journals that have published at least 100 papers and have at least one citation in a period of five years (2007-2011). Journal rankings are sorted by languages (showing the 100 papers with the greatest impact). This tool allows to sort by subject areas and disciplines, but only in the case of journals in English. In this case, it only shows the 20 journals with the highest h index. This option is not available for journals in the other nine languages present in Google (Chinese, Portuguese, German, Spanish, French, Korean, Japanese, Dutch and Italian). Google Scholar Metrics doesnt currently allow to group and sort all journals belonging to a scientific discipline. In the case of Nursing, in the ten listings displayed by GSM we can only locate 34 journals. Therefore, in an attempt to overcome this limitation, we have used the diversity of search procedures allowed by GSM to identify the greatest number of sci
Rankings of scholarly journals based on citation data are often met with skepticism by the scientific community. Part of the skepticism is due to disparity between the common perception of journals' prestige and their ranking based on citation counts. A more serious concern is the inappropriate use of journal rankings to evaluate the scientific influence of authors. This paper focuses on analysis of the table of cross-citations among a selection of Statistics journals. Data are collected from the Web of Science database published by Thomson Reuters. Our results suggest that modelling the exchange of citations between journals is useful to highlight the most prestigious journals, but also that journal citation data are characterized by considerable heterogeneity, which needs to be properly summarized. Inferential conclusions require care in order to avoid potential over-interpretation of insignificant differences between journal ratings. Comparison with published ratings of institutions from the UK's Research Assessment Exercise shows strong correlation at aggregate level between assessed research quality and journal citation `export scores' within the discipline of Statistics.
We introduce a novel methodology for mapping academic institutions based on their journal publication profiles. We believe that journals in which researchers from academic institutions publish their works can be considered as useful identifiers for representing the relationships between these institutions and establishing comparisons. However, when academic journals are used for research output representation, distinctions must be introduced between them, based on their value as institution descriptors. This leads us to the use of journal weights attached to the institution identifiers. Since a journal in which researchers from a large proportion of institutions published their papers may be a bad indicator of similarity between two academic institutions, it seems reasonable to weight it in accordance with how frequently researchers from different institutions published their papers in this journal. Cluster analysis can then be applied to group the academic institutions, and dendrograms can be provided to illustrate groups of institutions following agglomerative hierarchical clustering. In order to test this methodology, we use a sample of Spanish universities as a case study. We f
Using a systematic review and meta-analysis, this study investigates the impact of the COVID-19 pandemic on job burnout among nurses. We review healthcare articles following the PRISMA 2020 guidelines and identify the main aspects and factors of burnout among nurses during the pandemic. Using the Maslach Burnout questionnaire, we searched PubMed, ScienceDirect, and Google Scholar, three open-access databases, for relevant sources measuring emotional burnout, personal failure, and nurse depersonalization. Two reviewers extract and screen data from the sources and evaluate the risk of bias. The analysis reveals that 2.75% of nurses experienced job burnout during the pandemic, with a 95% confidence interval and rates varying from 1.87% to 7.75%. These findings emphasize the need for interventions to address the pandemic's effect on job burnout among nurses and enhance their well-being and healthcare quality. We recommend considering individual, organizational, and contextual factors influencing healthcare workers' burnout. Future research should focus on identifying effective interventions to lower burnout in nurses and other healthcare professionals during pandemics and high-stress s
Phosphorus (P) is considered to be one of the key elements for life, making it an important element to look for in the abundance analysis of spectra of stellar systems. Yet, there exists only a handful of spectroscopic studies to estimate the P abundances and investigate its trend across a range of metallicities. We have observed full HK band spectra at a spectral resolving power of R=45,000 with IGRINS instrument. Abundances are determined using SME in combination with 1D MARCS stellar atmosphere models. The investigated sample of stars have reliable stellar parameters estimated using optical FIES spectra (GILD; Jönsson et al. in prep.). In order to determine the P abundances from the 16482.92 Angstrom P line, we take special care of the CO($ν=7-4$) blend. We determine the C, N, O abundances from atomic carbon and a range of non-blended molecular lines (CO, CN, OH) which are aplenty in the H band region of K giant stars, assuring an appropriate modelling of the blending CO($ν=7-4$) line. We present [P/Fe] vs [Fe/H] trend for 38 K giant stars in the metallicity range of -1.2 dex $<$ [Fe/H] $<$ 0.4 dex. We find that our trend matches well with the compiled literature sample of
As the aging population increases and the shortage of healthcare workers increases, the need to examine other means for caring for the aging population increases. One such means is the use of humanoid robots to care for social, emotional, and physical wellbeing of the people above 65. Understanding skilled and long term care nursing home administrators' perspectives on humanoid robots in caregiving is crucial as their insights shape the implementation of robots and their potential impact on resident well-being and quality of life. This authors surveyed two hundred and sixty nine nursing homes executives to understand their perspectives on the use of humanoid robots in their nursing home facilities. The data was coded and results revealed that the executives were keen on exploring other avenues for care such as robotics that would enhance their nursing homes abilities to care for their residents. Qualitative analysis reveals diverse perspectives on integrating humanoid robots in nursing homes. While acknowledging benefits like improved engagement and staff support, concerns persist about costs, impacts on human interaction, and doubts about robot effectiveness. This highlights compl
Background: Telephone nursing is the first line of contact for many care-seekers and aims at optimizing the performance of the healthcare system by supporting and guiding patients to the correct level of care and reduce the amount of unscheduled visits. Good statistical models that describe the effects of telephone nursing are important in order to study its impact on healthcare resources and evaluate changes in telephone nursing procedures. Objective: To develop a valid model that captures the complex relationships between the nurse's recommendations, the patients' intended actions and the patients' health seeking behavior. Using the model to estimate the effects of telephone nursing on patient behavior, healthcare utilization, and infer potential cost savings. Methods: Bayesian ordinal regression modeling of data from randomly selected patients that received telephone nursing. Inference is based on Markov Chain Monte Carlo methods, model selection using the Watanabe-Akaike Information Criteria, and model validation using posterior predictive checks on standard discrepancy measures. Results and Conclusions: We present a robust Bayesian ordinal regression model that predicts 76% of
We present the results of processing the effects of the powerful Gamma Ray Burst GRB221009A captured by the charged particle detectors (electrostatic analyzers and solid-state detectors) onboard spacecraft at different points in the heliosphere on October 9, 2022. To follow the GRB221009A propagation through the heliosphere we used the electron and proton flux measurements from solar missions Solar Orbiter and STEREO-A; Earth magnetosphere and the solar wind missions THEMIS and Wind; meteorological satellites POES15, POES19, MetOp3; and MAVEN - a NASA mission orbiting Mars. GRB221009A had a structure of four bursts: less intense Pulse 1 - the triggering impulse - was detected by gamma-ray observatories at 131659 UT (near the Earth); the most intense Pulses 2 and 3 were detected on board all the spacecraft from the list, and Pulse 4 detected in more than 500 s after Pulse 1. Due to their different scientific objectives, the spacecraft, which data was used in this study, were separated by more than 1 AU (Solar Orbiter and MAVEN). This enabled tracking GRB221009A as it was propagating across the heliosphere. STEREO-A was the first to register Pulse 2 and 3 of the GRB, almost 100 secon
Eccentric planets may spend a significant portion of their orbits at large distances from their host stars, where low temperatures can cause atmospheric CO2 to condense out onto the surface, similar to the polar ice caps on Mars. The radiative effects on the climates of these planets throughout their orbits would depend on the wavelength-dependent albedo of surface CO2 ice that may accumulate at or near apoastron and vary according to the spectral energy distribution of the host star. To explore these possible effects, we incorporated a CO2 ice-albedo parameterization into a one-dimensional energy balance climate model. With the inclusion of this parameterization, our simulations demonstrated that F-dwarf planets require 29% more orbit-averaged flux to thaw out of global water ice cover compared with simulations that solely use a traditional pure water ice-albedo parameterization. When no eccentricity is assumed, and host stars are varied, F-dwarf planets with higher bond albedos relative to their M-dwarf planet counterparts require 30% more orbit-averaged flux to exit a water snowball state. Additionally, the intense heat experienced at periastron aids eccentric planets in exiting
Soft substrates such as polydimethylsiloxane (PDMS) enhance droplet nucleation during the condensation of water vapour, because their deformability inherently reduces the energetic threshold for heterogeneous nucleation relative to rigid substrates. However, this enhanced droplet nucleation is counteracted later in the condensation cycle, when the viscoelastic dissipation inhibits condensate droplet shedding from the substrate. Here, we show that bulk lubricant infusion in the soft substrate is a potential pathway for overcoming this limitation. We demonstrate that even 5% bulk lubricant infusion in PDMS reduces viscoelastic dissipation in the substrate by more than 30 times and more than doubles the droplet nucleation density. We correlate the droplet nucleation and growth rate with the material properties controlled by design, i.e. the fraction and composition of uncrosslinked chains, shear modulus, and viscoelastic dissipation. Through in-situ, microscale condensation on the substrates, we show that the increase in nucleation density and reduction in pre-coalescence droplet growth rate is insensitive to the percentage of lubricant in PDMS. Our results indicate the presence of a
The development of modern nursing and consequently nursing research in Ex- Yugoslavia is about a century old. To profile the development, volume, and content of nursing research we completed a performance and spatial bibliometric analysis combined with synthetic content analysis to identify the most productive countries and institutions, most prolific source titles, country cooperation, publication production trends, the content of research and hot topics. The corpus was harvested from the Web of Science All databases and contained 1380 papers. Slovenia was the most productive country, followed by Croatia and Serbia. The synthetic content analysis demonstrated that nursing research in ex-Yugoslavian countries is growing both in scope and number of publications, notwithstanding the fact that research content differs between countries and it seems that each country is focused on their local health problems. A substantial part of the research is published in national journals in national languages however, it is noteworthy to note that some ex-Yugoslavian authors have succeeded in publishing their research in top nursing journals. The study also revealed substantial international coop