Juvenile fibromyalgia syndrome (JFMS) is a chronic condition characterized by symptoms of chronic diffuse musculoskeletal pain and multiple painful tender points on palpation. It is often accompanied by fatigue, disorders of sleep, chronic headaches, irritable bowel syndrome, and subjective soft tissue swelling. The complexity of the presenting clinical picture in JPFS has not been sufficiently defined in the literature. Similarities to adult fibromyalgia syndrome in JFMS are often difficult to compare, because many of the symptoms are "medically unexplained" and often overlap frequently with other medical conditions. However, a valid diagnosis of JFMS often decreases parents' anxiety, reduces unnecessary further investigations, and provides a rational framework for a management plan. The diagnostic criteria proposed by Yunus and Masi in 1985 to define JFMS were never validated or critically analyzed. In most cases, the clinical diagnosis is based on the history, the physical examination that demonstrates general tenderness (muscle, joints, tendons), the absence of other pathological conditions that could explain pain and fatigue, and the normal basic laboratory tests. Research and clinical observations defined that JFMS may have a chronic course that impacts the functional status and the psychosocial development of children and adolescents. This paper briefly reviews the existing knowledge on JFMS focusing on the diagnosis, clinical and the epidemiological characteristics in children and adolescents for better understanding of this disorder.
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A procedure for determining the Burgers vector anisotropy in irradiated ferritic steels is described, allowing identification of all a ⟨ 100 ⟩ and all a/2 ⟨ 111 ⟩ dislocations in a region of interest. The necessary micrographs to apply the procedure have been taken of a pressurized tube specimen of JFMS, a duplex ferritic steel following irradiation in FFTF/MOTA at 407°C to 7.5 × 1022 n/cm2 (E > 0.1 MeV) or 37.5 dpa, and a pressurized tube of JLF-1 irradiated at 430°C under similar conditions to 14.3 × 1022 n/cm2 (E > 0.1 MeV) or 60 dpa. Analysis of micrographs indicates that large anisotropy in Burgers vector populations develop during irradiation creep.
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The authors exploit the remarkable similarity between recent climate trends and the structure of the “annular modes” in the month-to-month variability (as described in a companion paper) to partition the trends into components linearly congruent with and linearly independent of the annular modes. The index of the Northern Hemisphere (NH) annular mode, referred to as the Arctic Oscillation (AO), has exhibited a trend toward the high index polarity over the past few decades. The largest and most significant trends are observed during the “active season” for stratospheric planetary wave–mean flow interaction, January–March (JFM), when fluctuations in the AO amplify with height into the lower stratosphere. For the periods of record considered, virtually all of the JFM geopotential height falls over the polar cap region and the strengthening of the subpolar westerlies from the surface to the lower stratosphere, ∼50% of the JFM warming over the Eurasian continent, ∼30% of the JFM warming over the NH as a whole, ∼40% of the JFM stratospheric cooling over the polar cap region, and ∼40% of the March total column ozone losses poleward of 40°N are linearly congruent with month-to-month variations in the AO index. Summertime sea level pressure falls over the Arctic basin are suggestive of a year-round drift toward the positive polarity of the AO, but the evidence is less conclusive. Owing to the photochemical memory inherent in the ozone distribution, roughly half the ozone depletion during the NH summer months is linearly dependent on AO-related ozone losses incurred during the previous active season. Lower-tropospheric geopotential height falls over the Antarctic polar cap region are indicative of a drift toward the high index polarity of the Southern Hemisphere (SH) annular mode with no apparent seasonality. In contrast, the trend toward a cooling and strengthening of the SH stratospheric polar vortex peaks sharply during the stratosphere’s relatively short active season centered in November. The most pronounced SH ozone losses have occurred in September–October, one or two months prior to this active season. In both hemispheres, positive feedbacks involving ozone destruction, cooling, and a weakening of the wave-driven meridional circulation may be contributing to a delayed breakdown of the polar vortex and enhanced ozone losses during spring.
Regional or local climate change modeling studies currently require starting with a global climate model, then downscaling to the region of interest. How should global models be chosen for such studies, and what effect do such choices have? This question is addressed in the context of a regional climate detection and attribution (D&A) study of January-February-March (JFM) temperature over the western U.S. Models are often selected for a regional D&A analysis based on the quality of the simulated regional climate. Accordingly, 42 performance metrics based on seasonal temperature and precipitation, the El Nino/Southern Oscillation (ENSO), and the Pacific Decadal Oscillation are constructed and applied to 21 global models. However, no strong relationship is found between the score of the models on the metrics and results of the D&A analysis. Instead, the importance of having ensembles of runs with enough realizations to reduce the effects of natural internal climate variability is emphasized. Also, the superiority of the multimodel ensemble average (MM) to any 1 individual model, already found in global studies examining the mean climate, is true in this regional study that includes measures of variability as well. Evidence is shown that this superiority is largely caused by the cancellation of offsetting errors in the individual global models. Results with both the MM and models picked randomly confirm the original D&A results of anthropogenically forced JFM temperature changes in the western U.S. Future projections of temperature do not depend on model performance until the 2080s, after which the better performing models show warmer temperatures.
Recent loss of summer sea ice in the Arctic is directly connected to shifts in northern wind patterns in the following autumn, which has the potential of altering the heat budget at the cold end of the global heat engine. With continuing loss of summer sea ice to less than 20% of its climatological mean over the next decades, we anticipate increased modification of atmospheric circulation patterns. While a shift to a more meridional atmospheric climate pattern, the Arctic Dipole (AD), over the last decade contributed to recent reductions in summer Arctic sea ice extent, the increase in late summer open water area is, in turn, directly contributing to a modification of large scale atmospheric circulation patterns through the additional heat stored in the Arctic Ocean and released to the atmosphere during the autumn season. Extensive regions in the Arctic during late autumn beginning in 2002 have surface air temperature anomalies of greater than 3 °C and temperature anomalies above 850 hPa of 1 °C. These temperatures contribute to an increase in the 1000–500 hPa thickness field in every recent year with reduced sea ice cover. While gradients in this thickness field can be considered a baroclinic contribution to the flow field from loss of sea ice, atmospheric circulation also has a more variable barotropic contribution. Thus, reduction in sea ice has a direct connection to increased thickness fields in every year, but not necessarily to the sea level pressure (SLP) fields. Compositing wind fields for late autumn 2002–2008 helps to highlight the baroclinic contribution; for the years with diminished sea ice cover there were composite anomalous tropospheric easterly winds of ∼1.4ms–1, relative to climatological easterly winds near the surface and upper troposphericwesterlies of ∼3 m s–1. Loss of summer sea ice is supported by decadal shifts in atmospheric climate patterns. A persistent positive Arctic Oscillation pattern in late autumn (OND) during 1988–1994 and in winter (JFM) during 1989–1997 shifted to more interannual variability in the following years. An anomalous meridional wind pattern with high SLP on the North American side of the Arctic—the AD pattern, shifted from primarily small interannual variability to a persistent phase during spring (AMJ) beginning in 1997 (except for 2006) and extending to summer (JAS) beginning in 2005.
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Summary. We define the notion of an initial segment of natural numbers and prove a number of their properties. Using this notion we introduce finite sequences, subsequences, the empty sequence, a sequence of a domain, and the operation of concatenation of two sequences. MML Identifier:FINSEQ_1. WWW:http://mizar.org/JFM/Vol1/finseq_1.html
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Abstract In this study, a cyclone detection/tracking algorithm was used to identify cyclones from two gridded 6-hourly mean sea level pressure datasets: the 40-yr ECMWF Re-Analysis (ERA-40) and the NCEP–NCAR reanalysis (NNR) for 1958–2001. The cyclone activity climatology and changes inferred from the two reanalyses are intercompared. The cyclone climatologies and trends are found to be in reasonably good agreement with each other over northern Europe and eastern North America, while ERA-40 shows systematically stronger cyclone activity over the boreal extratropical oceans than does NNR. However, significant differences between ERA-40 and NNR are seen over the austral extratropics. In particular, ERA-40 shows significantly greater strong-cyclone activity and less weak-cyclone activity over all oceanic areas south of 40°S in all seasons, while it shows significantly stronger cyclone activity over most areas of the austral subtropics in the warm seasons. The most notable historical trends in cyclone activity are found to be associated with strong-cyclone activity. Over the boreal extratropics, both ERA-40 and NNR show a significant increasing trend in January–March (JFM) strong-cyclone activity over the high-latitude North Atlantic and over the midlatitude North Pacific, with a significant decreasing trend over the midlatitude North Atlantic and a small increasing trend over northern Europe. The JFM changes over the North Atlantic are associated with the mean position of the storm track shifting about 181 km northward. Importantly, there is no evidence of abrupt changes identified for the boreal extratropics, although previous studies have suggested that the upward trend found in the NNR data could be biased high. However, there exist a few abrupt changes over the austral extratropics, which appear to be attributable to the increasing availability of observations assimilated in the reanalyses. After diminishing the effects of these abrupt changes, strong-cyclone activity over the austral circumpolar oceanic region is identified to have an increasing trend in October–December (OND) and July–September (JAS), with a decreasing trend over the 40°–60°S zone in JAS.
Ca2+ release from heavy sarcoplasmic reticulum (SR) vesicles was induced by 2 mM caffeine, and the amount (A) and the rate constant (k) of Ca2+ release were investigated as a function of the extent of Ca2+ loading. Under both passive and active loading conditions, the A value increased monotonically in parallel to Ca2+ loading. On the other hand, k sharply increased at partial Ca2+ loading, and upon further loading, it decreased to a lower level. Since most of the intravesicular calcium appears to be bound to calsequestrin both under passive and under active loading conditions, these results suggest that the kinetic properties of induced Ca2+ release show significant variation depending upon how much calcium has been bound to calsequestrin at the time of the induction of Ca2+ release. An SR membrane segment consisting of the junctional face membrane (jfm) and attached calsequestrin (jfm-calsequestrin complex) was prepared. The covalently reacting thiol-specific conformational probe N-[7-(dimethylamino)-4-methyl-3-coumarinyl]maleimide (DACM) was incorporated into several proteins of the jfm, but not into calsequestrin. The fluorescence intensity of DACM increased with Ca2+. Upon dissociation of calsequestrin from the jfm by salt treatment, the DACM fluorescence change was abolished, while upon reassociation of calsequestrin by dilution of the salt it was partially restored. These results suggest that the events occurring in the jfm proteins are mediated via the attached calsequestrin rather than by a direct effect of Ca2+ on the jfm proteins. We propose that the [Ca2+]-dependent conformational changes of calsequestrin affect the jfm proteins and in turn regulate the Ca2+ channel functions.
This article examines the concept of ‘jointness’ in India’s Joint Forest Management (JFM) programme, understood as an engagement between the state (in this case the Forest Department) and people organized into ‘communities’, with NGOs, where available, acting as the interface. By examining the commonalities between older examples of joint or co‐management of resources and current practices of joint forest management, the article challenges the notion that ‘jointness’ is a new feature of forest policy, or that it represents a resurgence of civil society against the state. Further, insofar as the basic agenda of the programme is pre‐determined, it cannot be considered very participatory in nature. None the less, within the limited degree of choice that JFM allows, there is a new and joint construction of needs.
Away from the tropical Pacific Ocean, an ENSO event is associated with relatively minor changes of the probability distributions of atmospheric variables. It is nonetheless important to estimate the changes accurately for each ENSO event, because even small changes of means and variances can imply large changes of the likelihood of extreme values. The mean signals are not strictly symmetric with respect to El Niño and La Niña. They also depend upon the unique aspects of the SST anomaly patterns for each event. As for changes of variance and higher moments, little is known at present. This is a concern especially for precipitation, whose distribution is strongly skewed in areas of mean tropospheric descent. These issues are examined here in observations and GCM simulations of the northern winter (January–March, JFM). For the observational analysis, the 42-yr (1958–99) reanalysis data generated at NCEP are stratified into neutral, El Niño, and La Niña winters. The GCM analysis is based on NCEP atmospheric GCM runs made with prescribed seasonally evolving SSTs for neutral, warm, and cold ENSO conditions. A large number (180) of seasonal integrations, differing only in initial atmospheric states, are made each for observed climatological mean JFM SSTs, the SSTs for an observed warm event (JFM 1987), and the SSTs for an observed cold event (JFM 1989). With such a large ensemble, the changes of probability even in regions not usually associated with strong ENSO signals are ascertained. The results suggest a substantial asymmetry in the remote response to El Niño and La Niña, not only in the mean but also the variability. In general the remote seasonal mean geopotential height response in the El Niño experiment is stronger, but also more variable, than in the La Niña experiment. One implication of this result is that seasonal extratropical anomalies may not necessarily be more predictable during El Niño than La Niña. The stronger seasonal extratropical variability during El Niño is suggested to arise partly in response to stronger variability of rainfall over the central equatorial Pacific Ocean. The changes of extratropical variability in these experiments are large enough to affect substantially the risks of extreme seasonal anomalies in many regions. These and other results confirm that the remote impacts of individual tropical ENSO events can deviate substantially from historical composite El Niño and La Niña signals. They also highlight the necessity of generating much larger GCM ensembles than has traditionally been done to estimate reliably the changes to the full probability distribution, and especially the altered risks of extreme anomalies, during those events.
Abstract This study uses bibliometrics to present a retrospective on the Journal of Futures Markets ( JFM ) on its 40th anniversary. The Journal's annual number of publications and citations grew substantially, with US‐affiliated authors being the dominant contributors. Authorship analysis reveals an increase in collaboration and diversity among JFM authors. Bibliographic coupling analysis reveals that the Journal's main themes include commodities, volatility, trading, hedging, arbitrage and pricing, forecasting volatility, and credit default swaps. Its primary citation drivers are article age, article length, number of authors, FT100 affiliation, and references.
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The most severe effects of global warning will be related to the frequency and severity of extreme events. We provide an analysis of projections of temperature and related extreme events for Africa based on a large ensemble of Regional Climate Models from the COordinated Regional climate Downscaling EXperiment (CORDEX). Results are presented not only by means of widely used indices but also with a recently developed Heat Wave Magnitude Index-daily (HWMId), which takes into account both heat wave duration and intensity. Results show that under RCP8.5, warming of more than 3.5 °C is projected in JFM over most of the continent, whereas in JAS temperatures over large part of Northern Africa, the Sahara and the Arabian peninsula are projected to increase up to 6 °C. Large increase in in the number of warm days (Tx90p) is found over sub equatorial Africa, with values up to more than 90 % in JAS, and more than 80 % in JFM over e.g., the gulf of Guinea, Central African Republic, South Sudan and Ethiopia. Changes in Tn90p (warm nights) are usually larger, with some models projecting Tn90p reaching 95 % starting from around 2060 even under RCP4.5 over the Gulf of Guinea and the Sahel. Results also show that the total length of heat spells projected to occur normally (i.e. once every 2 years) under RCP8.5 may be longer than those occurring once every 30 years under the lower emission scenario. By employing the recently developed HWMId index, it is possible to investigate the relationship between heat wave length ad intensity; in particular it is shown that very intense heat waves such as that occurring over the Horn of Africa may have values of HWMId larger than that of longer, but relatively weak, heat waves over West Africa.