The premature development of artificial superintelligence poses major risks to humanity, so researchers have proposed international agreements halting such development until it can be done safely. AI progress depends primarily on compute, algorithms, and data; a durable halt would address all three so that advances in one input do not counteract restrictions on another. Improvements to AI algorithms are driven largely through research activities, so this research may need to be restricted during a halt. Given low international trust, signatories will want to verify compliance. This paper analyzes how such restrictions on AI research could be verified, while remaining agnostic about what specific research would be prohibited. It first explores key considerations that affect the verifiability of research restrictions, such as the computational infrastructure necessary for experiments. It then catalogs 28 candidate verification mechanisms. These mechanisms include whistleblowers, search warrants, reviews of AI training code, standard intelligence gathering tools, and more. Some of these mechanisms are not yet implementation-ready, and some might be undesirable upon further inspection.
Software is at the core of most scientific discoveries today. Therefore, the quality of research results highly depends on the quality of the research software. Rigorous testing, as we know it from software engineering in the industry, could ensure the quality of the research software but it also requires a substantial effort that is often not rewarded in academia. Therefore, this research explores the effects of research software testing integrated into teaching on research software. In an in-vivo experiment, we integrated the engineering of a test suite for a large-scale network simulation as group projects into a course on software testing at the Blekinge Institute of Technology, Sweden, and qualitatively measured the effects of this integration on the research software. We found that the research software benefited from the integration through substantially improved documentation and fewer hardware and software dependencies. However, this integration was effortful and although the student teams developed elegant and thoughtful test suites, no code by students went directly into the research software since we were not able to make the integration back into the research software
This paper presents multi- and interdisciplinary approaches for finding the appropriate AI technologies for research information. Professional research information management (RIM) is becoming increasingly important as an expressly data-driven tool for researchers. It is not only the basis of scientific knowledge processes, but also related to other data. A concept and a process model of the elementary phases from the start of the project to the ongoing operation of the AI methods in the RIM is presented, portraying the implementation of an AI project, meant to enable universities and research institutions to support their researchers in dealing with incorrect and incomplete research information, while it is being stored in their RIMs. Our aim is to show how research information harmonizes with the challenges of data literacy and data quality issues, related to AI, also wanting to underline that any project can be successful if the research institutions and various departments of universities, involved work together and appropriate support is offered to improve research information and data management.
This paper presents a scientometric analysis of research output from the University of Lagos, focusing on the two decades spanning 2004 to 2023. Using bibliometric data retrieved from the Web of Science, we examine trends in publication volume, collaboration patterns, citation impact, and the most prolific authors, departments, and research domains at the university. The study reveals a consistent increase in research productivity, with the highest publication output recorded in 2023. Health Sciences, Engineering, and Social Sciences are identified as dominant fields, reflecting the university's interdisciplinary research strengths. Collaborative efforts, both locally and internationally, show a positive correlation with higher citation impact, with the United States and the United Kingdom being the leading international collaborators. Notably, open-access publications account for a significant portion of the university's research output, enhancing visibility and citation rates. The findings offer valuable insights into the university's research performance over the past two decades, providing a foundation for strategic planning and policy formulation to foster research excellence
Modern research heavily relies on software. A significant challenge researchers face is understanding the complex software used in specific research fields. We target two scenarios in this context, namely long onboarding times for newcomers and conference reviewers evaluating replication packages. We hypothesize that both scenarios can be significantly improved when there is a clear link between the paper's ideas and the code that implements them. As a time- and staff-saving approach, we propose an LLM-based automation tool that takes in a paper and the software implementing the paper, and generates a trace mapping between research ideas and their locations in code. Initial experiments have shown that the tool can generate quite useful mappings.
Demographic data collection is essential in education research, as demographic data allows researchers to better describe the participant population they study and to contextualize findings. However, current research practices for neurodiversity demographics often rely on prescriptive methods (e.g., requiring participants to report official diagnoses) rather than allowing participants to self-identify. This approach can: a) not allow participants to express their intersecting identities in ways that are authentic; and b) limit trustworthiness and reliability of the data and interpretation. In addition, inconsistent dissemination and representation of demographic data across studies hinder the accessibility and usability of this work. Through a literature review of neurodivergent student experiences with learning and performing STEM, we identified widespread discrepancies in how demographic information is collected and reported. This paper explores how neurodivergent identities can be more accurately and inclusively represented in education research. We present findings of a thematic analysis on the ways neurodivergent demographic data collection is done in the literature using data
Current gastric cancer (GCa) risk systems are prone to errors since they evaluate a visual estimation of intestinal metaplasia percentages in histopathology images of gastric mucosa to assign a risk. This study presents an automated method to detect and quantify intestinal metaplasia using deep convolutional neural networks as well as a comparative analysis with visual estimations of three pathologists. Gastric samples were collected from two different cohorts: 149 asymptomatic volunteers from a region with a high prevalence of GCa in Colombia and 56 patients from a tertiary hospital. Deep learning models were trained to classify intestinal metaplasia, and predictions were used to estimate a percentage of intestinal metaplasia and to assign an adapted OLGIM stage. Atrophy was not assessed because of the limited reproducibility among pathologists. Results were compared with independent blinded metaplastic assessments performed by three graduated pathologists. The best-performing deep learning architecture classified intestinal metaplasia with F1-Score of 0.80 +- 0.01 and AUC of 0.91 +- 0.01. Among pathologists, inter-observer agreement by a Fleiss's Kappa score ranged from 0.20 to 0
Intestinal microecology is established from birth and is constantly changing until homeostasis is reached. Intestinal microecology is involved in the immune inflammatory response of the intestine and regulates the intestinal barrier function. The imbalance of intestinal microecology is closely related to the occurrence and development of digestive system diseases. In some gastrointestinal diseases related to pediatric surgery, intestinal microecology and its metabolites undergo a series of changes, which can provide a certain basis for the diagnosis of diseases. The continuous development of microecological agents and fecal microbiota transplantation technology has provided a new means for its clinical treatment. We review the relationship between pathogenesis, diagnosis and treatment of pediatric surgery-related gastrointestinal diseases and intestinal microecology, in order to provide new ideas and methods for clinical diagnosis, treatment and research.
Scientists' topic choices strongly influence both individual careers and the advancement of the scientific frontier. While a sizeable body of literature shows that specialisation in a few topics benefits individual careers and fosters impactful research, the role of research teams and their experience have been largely overlooked. This paper introduces experience as a concept distinct from specialisation and shifts the level of analysis from the individual to the research team, reflecting the increasingly team-based nature of science. Using novel publication-level measures of team specialisation and team experience applied to nearly 1 million biomedical publications, the study finds that both are positively associated with citation impact. However, the correlation with citation impact is markedly stronger for team experience than for team specialisation. The study demonstrates how science can be examined at the team level and suggests that future research should pay more attention to studying experience.
Today, scientific research is increasingly data-centric and compute-intensive, relying on data and models across distributed sources. However, it still faces challenges in the traditional cooperation mode, due to the high storage and computing cost, geo-location barriers, and local confidentiality regulations. The Jupyter environment has recently emerged and evolved as a vital virtual research environment for scientific computing, which researchers can use to scale computational analyses up to larger datasets and high-performance computing resources. Nevertheless, existing approaches lack robust support of a decentralized cooperation mode to unlock the full potential of decentralized collaborative scientific research, e.g., seamlessly secure data sharing. In this work, we change the basic structure and legacy norms of current research environments via the seamless integration of Jupyter with Ethereum blockchain capabilities. As such, it creates a Decentralized Virtual Research Environment (D-VRE) from private computational notebooks to decentralized collaborative research ecosystem. We propose a novel architecture for the D-VRE and prototype some essential D-VRE elements for enabli
This scientometric study analyzes Avian Influenza research from 2014 to 2023 using bibliographic data from the Web of Science database. We examined publication trends, sources, authorship, collaborative networks, document types, and geographical distribution to gain insights into the global research landscape. Results reveal a steady increase in publications, with high contributions from Chinese and American institutions. Journals such as PLoS One and the Journal of Virology published the highest number of studies, indicating their influence in this field. The most prolific institutions include the Chinese Academy of Sciences and the University of Hong Kong, while the College of Veterinary Medicine at South China Agricultural University emerged as the most productive department. China and the USA lead in publication volume, though developed nations like the United Kingdom and Germany exhibit a higher rate of international collaboration. "Articles" are the most common document type, constituting 84.6% of the total, while "Reviews" account for 7.6%. This study provides a comprehensive view of global trends in Avian Influenza research, emphasizing the need for collaborative efforts ac
This study introduces an advanced multiphysics and multiscale modeling approach to investigate intestinal motility. We propose a generalized electromechanical framework that incorporates contact mechanics, enabling the development of a unique and innovative model for intestinal motility. The theoretical framework includes an electromechanical model coupling a microstructural material model, which describes the intestinal structure, with an electrophysiological model that captures the propagation of slow waves. Additionally, it integrates a self-contact detection algorithm based on a nearest-neighbour search and the penalty method, along with boundary conditions that account for the influence of surrounding organs. A staggered finite element scheme implemented in FEniCS is employed to solve the governing equations using the finite element method. The model is applied to study cases of moderate and severe strangulation hernia, as well as intestinal adhesion syndrome. The results demonstrate that low peristalsis takes place in the pre-strangulation zone. At the same time, very high pressure is recorded in the strangulation zone, and peristaltic contractions persisted in the healthy re
Drawing on 1,178 safety and reliability papers from 9,439 generative AI papers (January 2020 - March 2025), we compare research outputs of leading AI companies (Anthropic, Google DeepMind, Meta, Microsoft, and OpenAI) and AI universities (CMU, MIT, NYU, Stanford, UC Berkeley, and University of Washington). We find that corporate AI research increasingly concentrates on pre-deployment areas -- model alignment and testing & evaluation -- while attention to deployment-stage issues such as model bias has waned. Significant research gaps exist in high-risk deployment domains, including healthcare, finance, misinformation, persuasive and addictive features, hallucinations, and copyright. Without improved observability into deployed AI, growing corporate concentration could deepen knowledge deficits. We recommend expanding external researcher access to deployment data and systematic observability of in-market AI behaviors.
A new computational framework for modeling the intestinal wall as a multi-layered fiber-reinforced continuum is presented. The framework reproduces for the first time physiological motility and overcoming large-displacements limitations (self-contact and volume locking) occurring in classical hyperelastic formulations of soft tissues. We introduce: i) layer-specific functions, segregating active circumferential and longitudinal muscle fibers while maintaining homogeneous passive reinforcement, and ii) a quasi-incompressible volumetric contribution, to handle large peristaltic contractions. Cell electrophysiology is further extended to reproduce both slow waves and spike bursting activities thus mimicking for the first time a localized neural excitation in a three-dimensional geometry of small intestine segment. We introduce a spatio-temporal modulation of contractility to accurately capture activation driven by both slow waves and spike bursts. The overall coupled nonlinear electromechanical boundary valued problem is modeled following the active strain approach. A robust augmented-Lagrangian contact algorithm is also embedded to avoid self-penetration and geometrical instabilities
Research is facing a reproducibility crisis, in which the results and findings of many studies are difficult or even impossible to reproduce. This is also the case in machine learning (ML) and artificial intelligence (AI) research. Often, this is the case due to unpublished data and/or source-code, and due to sensitivity to ML training conditions. Although different solutions to address this issue are discussed in the research community such as using ML platforms, the level of reproducibility in ML-driven research is not increasing substantially. Therefore, in this mini survey, we review the literature on reproducibility in ML-driven research with three main aims: (i) reflect on the current situation of ML reproducibility in various research fields, (ii) identify reproducibility issues and barriers that exist in these research fields applying ML, and (iii) identify potential drivers such as tools, practices, and interventions that support ML reproducibility. With this, we hope to contribute to decisions on the viability of different solutions for supporting ML reproducibility.
In this work, we study a system of degenerate parabolic equations modeling the dynamics of multiple cell populations in intestinal crypts. The model describes cell division, differentiation, and migration through a strongly coupled system of reaction-cross-diffusion equations with degenerate diffusion. By working with initial data in BV, we first consider a regularized form of the system and establish uniform BV estimates. Using these bounds, we then pass to the limit to obtain the existence of weak solutions.
The primary function of intestinal microvilli is to increase the surface area of the intestinal lining to maximize nutrient absorption. This is especially important as fish, like other animals, need to efficiently absorb proteins, carbohydrates, lipids, vitamins, and minerals from their digested food to support their growth and energy needs. Despite its importance to the fish health, the small size and dense footprint of microvilli hinders its investigation and necessitates the need of advanced microscopy methods for its visualization. Characterization of the microvilli using super-resolution microscopy provides insights into their structural organization, spatial distribution, and surface properties. Here, we present a comprehensive investigation of different optical, electron and force microscopy methods for analysis of fish microvilli. The super-resolution optical microscopy methods used are 3D structured illumination microscopy (SIM), stimulated emission depletion microscopy (STED), and fluorescence fluctuation based super-resolution microscopy (FF-SRM). We also visualized the intestinal microvilli in fish using diffraction-limited optical microscopy methods including confocal
This paper presents, for the first time, an image enhancement methodology designed to enhance the clarity of small intestinal villi in Wireless Capsule Endoscopy (WCE) images. This method first separates the low-frequency and high-frequency components of small intestinal villi images using guided filtering. Subsequently, an adaptive light gain factor is generated based on the low-frequency component, and an adaptive gradient gain factor is derived from the convolution results of the Laplacian operator in different regions of small intestinal villi images. The obtained light gain factor and gradient gain factor are then combined to enhance the high-frequency components. Finally, the enhanced high-frequency component is fused with the original image to achieve adaptive sharpening of the edges of WCE small intestinal villi images. The experiments affirm that, compared to established WCE image enhancement methods, our approach not only accentuates the edge details of WCE small intestine villi images but also skillfully suppresses noise amplification, thereby preventing the occurrence of edge overshooting.
The production of knowledge has become increasingly a global endeavor. Yet, location related factors, such as local working environment and national policy designs, may continue to affect what kind of science is being pursued. Here we examine the geography of the production of creative science by country, through the lens of novelty and atypicality proposed in Uzzi et al. (2013). We quantify a country's representativeness in novel and atypical science, finding persistent differences in propensity to generate creative works, even among developed countries that are large producers in science. We further cluster countries based on how their tendency to publish novel science changes over time, identifying one group of emerging countries. Our analyses point out the recent emergence of China not only as a large producer in science but also as a leader that disproportionately produces more novel and atypical research. Discipline specific analysis indicates that China's over-production of atypical science is limited to a few disciplines, especially its most prolific ones like materials science and chemistry.
In most countries, basic research is supported by research councils that select, after peer review, the individuals or teams that are to receive funding. Unfortunately, the number of grants these research councils can allocate is not infinite and, in most cases, a minority of the researchers receive the majority of the funds. However, evidence as to whether this is an optimal way of distributing available funds is mixed. The purpose of this study is to measure the relation between the amount of funding provided to 12,720 researchers in Quebec over a fifteen year period (1998-2012) and their scientific output and impact from 2000 to 2013. Our results show that both in terms of the quantity of papers produced and of their scientific impact, the concentration of research funding in the hands of a so-called "elite" of researchers generally produces diminishing marginal returns. Also, we find that the most funded researchers do not stand out in terms of output and scientific impact.