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Temporal trends in postcranial robusticity within the genus Homo are explored by comparing cross-sectional diaphyseal and articular properties of the femur, and to a more limited extent, the humerus, in samples of Recent and earlier Homo. Using both theoretical mechanical models and empirical observations within Recent humans, scaling relationships between structural properties and bone length are developed. The influence of body shape on these relationships is considered. These scaling factors are then used to standardize structural properties for comparisons with pre-Recent Homo (Homo sp. and H. erectus, archaic H. sapiens, and early modern H. sapiens). Results of the comparisons lead to the following conclusions: 1) There has been a consistent, exponentially increasing decline in diaphyseal robusticity within Homo that has continued from the early Pleistocene through living humans. Early modern H. sapiens are closer in shaft robusticity to archaic H. sapiens than they are to Recent humans. The increase in diaphyseal robusticity in earlier Homo is a result of both medullary contraction and periosteal expansion relative to Recent humans. 2) There has been no similar temporal decline in articular robusticity within Homo--relative femoral head size is similar in all groups and time periods. Thus, articular to shaft proportions are different in pre-Recent and Recent Homo. 3) These findings are most consistent with a mechanical explanation (declining mechanical loading of the postcranium), that acted primarily through developmental rather than genetic means. The environmental (behavioral) factors that brought about the decline in postcranial robusticity in Homo are ultimately linked to increases in brain size and cultural-technological advances, although changes in robusticity lag behind changes in cognitive capabilities.

A reduced HOMO−LUMO gap, which is defined as the HOMO−LUMO energy separation of a molecule divided by that of the hypothetical polyene reference, can be used as an index of kinetic stability for a variety of polycyclic aromatic hydrocarbons (PAHs). The reduced HOMO−LUMO gap < 1.00 indicates that the HOMO contributes to the decrease in the topological resonance energy. In general, PAHs with reduced HOMO−LUMO gaps < 1.30 are chemically very reactive. Fully benzenoid hydrocarbons are kinetically very stable with very large reduced HOMO−LUMO gaps. Many of the PAH molecules with large reduced HOMO−LUMO gaps are closed-shell substructures of nonmetallic one-dimensional benzenoid polymers.

A complex of traits in the femur and pelvis of Homo erectus and early "erectus-like" specimens has been described, but never satisfactorily explained. Here the functional relationships between pelvic and femoral structure in humans are explored using both theoretical biomechanical models and empirical tests within modern samples of diverse body form (Pecos Amerindians, East Africans). Results indicate that a long femoral neck increases mediolateral bending of the femoral diaphysis and decreases gluteal abductor and hip joint reaction forces. Increasing biacetabular breadth along with femoral neck length further increases M-L bending of the femoral shaft and maintains abductor and joint reaction forces at near "normal" levels. When compared to modern humans, Homo erectus and early "erectus-like" specimens are characterized by a long femoral neck and greatly increased M-L relative to A-P bending strength of the femoral shaft, coupled with no decrease in hip joint size and a probable increase in abductor force relative to body size. All of this strongly suggests that biacetabular breadth as well as femoral neck length was relatively large in early Homo. Several features preserved in early Homo partial hip bones also indicate that the true (lower) pelvis was very M-L broad, as well as A-P narrow. This is similar to the lower pelvic shape of australopithecines and suggests that nonrotational birth, in which the newborn's head is oriented transversely through the pelvic outlet, characterized early Homo as well as Australopithecus. Because M-L breadth of the pelvis is constrained by other factors, this may have limited increases in cranial capacity within Homo until rotational birth was established during the late Middle Pleistocene. During or after the transition to rotational birth biacetabular breadth decreased, reducing the body weight moment arm about the hip and allowing femoral neck length (abductor moment arm) to also decrease, both of which reduced M-L bending of the proximal femoral shaft. Variation in femoral structural properties within early Homo and other East African Early Pleistocene specimens has several taxonomic and phylogenetic implications.

Homo naledi is a previously-unknown species of extinct hominin discovered within the Dinaledi Chamber of the Rising Star cave system, Cradle of Humankind, South Africa. This species is characterized by body mass and stature similar to small-bodied human populations but a small endocranial volume similar to australopiths. Cranial morphology of H. naledi is unique, but most similar to early Homo species including Homo erectus, Homo habilis or Homo rudolfensis. While primitive, the dentition is generally small and simple in occlusal morphology. H. naledi has humanlike manipulatory adaptations of the hand and wrist. It also exhibits a humanlike foot and lower limb. These humanlike aspects are contrasted in the postcrania with a more primitive or australopith-like trunk, shoulder, pelvis and proximal femur. Representing at least 15 individuals with most skeletal elements repeated multiple times, this is the largest assemblage of a single species of hominins yet discovered in Africa.

The first discoveries of Homo erectus were made in Java late in the 19th century. Since then many fossils have come to light in Africa as well as Asia. Homo erectus seems to have evolved in Africa before spreading to other regions of the Old World. This occurred over a long period of time, during which the populations changed relatively little. Only towards the close of the middle Pleistocene are there signs of change in evolutionary tempo leading to the appearance of more advanced humans. This book provides a wealth of information about individual crania, jaws and postcranial remains and will serve as an important guide to the anatomy of Homo erectus. It also documents the history of this extinct human species and suggests a route whereby Homo erectus may have given rise to people more like Homo sapiens.

Louis Dumont's modern classic, here presented in an enlarged, revised, and corrected second edition, simultaneously supplies that reader with the most cogent statement on the Indian caste system and its organizing principles and a provocative advance in the comparison of societies on the basis of their underlying ideologies. Dumont moves gracefully from the ethnographic data to the level of the hierarchical ideology encrusted in ancient religious texts which are revealed as the governing conception of the contemporary caste structure. On yet another plane of analysis, homo hierarchicus is contrasted with his modern Western antithesis, homo aequalis. This edition includes a lengthy new Preface in which Dumont reviews the academic discussion inspired by Homo Hierarchicus and answers his critics. A new Postface, which sketches the theoretical and comparative aspects of the concept of hierarchy, and three significant Appendixes previously omitted from the English translation complete this innovative and influential work.

Introduction Part I. The Logic of Sovereignty: 1. The paradox of sovereignty 2. 'Nomos Basileus' 3. Potentiality and law 4. Form of law Threshold Part II. Homo Sacer: 1. Homo sacer 2. The ambivalence of the sacred 3. Sacred life 4. 'Vitae Necisque Potestas' 5. Sovereign body and sacred body 6. The ban and the wolf Threshold Part III. The Camp as Biopolitical Paradigm of the Modern: 1. The politicization of life 2. Biopolitics and the rights of man 3. Life that does not deserve to live 4. 'Politics, or giving form to the life of a people' 5. VP 6. Politicizing death 7. The camp as the 'Nomos' of the modern Threshold Bibliography Index of names.

In seinem Kultbuch „Eine kurze Geschichte der Menschheit“ erklärte Yuval Noah Harari, wie unsere Spezies die Erde erobern konnte. In „Homo Deus“ stößt er vor in eine noch verborgene Welt: die Zukunft. Was wird mit uns und unserem Planeten passieren, wenn die neuen Technologien dem Menschen gottgleiche Fähigkeiten verleihen – schöpferische wie zerstörerische – und das Leben selbst auf eine völlig neue Stufe der Evolution heben? Wie wird es dem Homo Sapiens ergehen, wenn er einen technikverstärkten Homo Deus erschafft, der sich vom heutigen Menschen deutlicher unterscheidet als dieser vom Neandertaler? Was bleibt von uns und der modernen Religion des Humanismus, wenn wir Maschinen konstruieren, die alles besser können als wir? In unserer Gier nach Gesundheit, Glück und Macht könnten wir uns ganz allmählich so weit verändern, bis wir schließlich keine Menschen mehr sind.

Cellular processes often depend on interactions between proteins and the formation of macromolecular complexes. The impairment of such interactions can lead to deregulation of pathways resulting in disease states, and it is hence crucial to gain insights into the nature of macromolecular assemblies. Detailed structural knowledge about complexes and protein-protein interactions is growing, but experimentally determined three-dimensional multimeric assemblies are outnumbered by complexes supported by non-structural experimental evidence. Here, we aim to fill this gap by modeling multimeric structures by homology, only using amino acid sequences to infer the stoichiometry and the overall structure of the assembly. We ask which properties of proteins within a family can assist in the prediction of correct quaternary structure. Specifically, we introduce a description of protein-protein interface conservation as a function of evolutionary distance to reduce the noise in deep multiple sequence alignments. We also define a distance measure to structurally compare homologous multimeric protein complexes. This allows us to hierarchically cluster protein structures and quantify the diversity of alternative biological assemblies known today. We find that a combination of conservation scores, structural clustering, and classical interface descriptors, can improve the selection of homologous protein templates leading to reliable models of protein complexes.

In responding to a request for predictions about the future of economics, I predict that Homo Economicus will evolve into Homo Sapiens, or, more simply put, economics will become more related to human behavior. My specific predictions are that Homo Economicus will start to lose IQ, will become a slower learner, will start interacting with other species, and that economists will start to study human cognition, human emotion, and will distinguish more clearly between normative and descriptive theories.