搜索结果：Frontiers in neuroanatomy

Linear interpolation between fine-tuned checkpoints has been shown to trace the Pareto front between competing objectives, but whether extrapolative weight averaging can extend such frontiers to new checkpoints useful at inference time, without additional RL training, remains unclear. We study this question in RL for competitive programming, where hidden unit tests under time and memory limits enforce both functional correctness and computational efficiency. Starting from a shared initialization, we train checkpoints under nested unit-test coverage: low-coverage rewards require passing smaller-input tests, while high-coverage rewards require passing progressively larger tests up to the full suite. This sweep reveals the emergence of a correctness-efficiency frontier: on hard problems, higher-coverage reward reduces optimization failures but increases correctness failures, leaving solve rate nearly unchanged. Interpolation between low- and high-coverage checkpoints recovers this frontier, while extrapolation extends it beyond the trained endpoints. Both the frontier and its extrapolative continuation appear across three inference settings, pure reasoning, tool use, and agentic codin

Land use expansion is linked to major sustainability concerns including climate change, food security and biodiversity loss. This expansion is largely concentrated in so-called frontiers, defined here as places experiencing marked transformations due to rapid resource exploitation. Understanding the mechanisms shaping these frontiers is crucial for sustainability. Previous work focused mainly on explaining how active frontiers advance, in particular into tropical forests. Comparatively, our understanding of how frontiers emerge in territories considered marginal in terms of agricultural productivity and global market integration remains weak. We synthesize conceptual tools explaining resource and land-use frontiers, including theories of land rent and agglomeration economies, of frontiers as successive waves, spaces of territorialization, friction, and opportunities, anticipation and expectation. We then propose a new theory of frontier emergence, which identifies exogenous pushes, legacies of past waves, and actors anticipations as key mechanisms by which frontiers emerge. Processes of abnormal rent creation and capture and the built-up of agglomeration economies then constitute k

Object Goal Navigation (OGN) is a fundamental task for robots and AI, with key applications such as mobile robot image databases (MRID). In particular, mapless OGN is essential in scenarios involving unknown or dynamic environments. This study aims to enhance recent modular mapless OGN systems by leveraging the commonsense reasoning capabilities of large language models (LLMs). Specifically, we address the challenge of determining the visiting order in frontier-based exploration by framing it as a frontier ranking problem. Our approach is grounded in recent findings that, while LLMs cannot determine the absolute value of a frontier, they excel at evaluating the relative value between multiple frontiers viewed within a single image using the view image as context. We dynamically manage the frontier list by adding and removing elements, using an LLM as a ranking model. The ranking results are represented as reciprocal rank vectors, which are ideal for multi-view, multi-query information fusion. We validate the effectiveness of our method through evaluations in Habitat-Sim.

Zero-shot open-vocabulary object navigation has progressed rapidly with the emergence of large Vision-Language Models (VLMs) and Large Language Models (LLMs), now widely used as high-level decision-makers instead of end-to-end policies. Although effective, such systems often rely on iterative large-model queries at inference time, introducing latency and computational overhead that limit real-time deployment. To address this problem, we repurpose ray frontiers (R2F), a recently proposed frontier-based exploration paradigm, to develop an LLM-free framework for indoor open-vocabulary object navigation. While ray frontiers were originally used to bias exploration using semantic cues carried along rays, we reinterpret frontier regions as explicit, direction-conditioned semantic hypotheses that serve as navigation goals. Language-aligned features accumulated along out-of-range rays are stored sparsely at frontiers, where each region maintains multiple directional embeddings encoding plausible unseen content. In this way, navigation then reduces to embedding-based frontier scoring and goal tracking within a classical mapping and planning pipeline, eliminating iterative large-model reason

Stochastic Multi-Objective Optimization (SMOO) is critical for decision-making trading off multiple potentially conflicting objectives in uncertain environments. SMOO aims at identifying the Pareto frontier, which contains all mutually non-dominating decisions. The problem is highly intractable due to the embedded probabilistic inference, such as computing the marginal, posterior probabilities, or expectations. Existing methods, such as scalarization, sample average approximation, and evolutionary algorithms, either offer arbitrarily loose approximations or may incur prohibitive computational costs. We propose XOR-SMOO, a novel algorithm that with probability $1-δ$, obtains $γ$-approximate Pareto frontiers ($γ>1$) for SMOO by querying an SAT oracle poly-log times in $γ$ and $δ$. A $γ$-approximate Pareto frontier is only below the true frontier by a fixed, multiplicative factor $γ$. Thus, XOR-SMOO solves highly intractable SMOO problems (\#P-hard) with only queries to SAT oracles while obtaining tight, constant factor approximation guarantees. Experiments on real-world road network strengthening and supply chain design problems demonstrate that XOR-SMOO outperforms several baseli

Language models encode text as subword tokens, raw bytes, or rendered pixels, but these encodings are usually compared under modeling constraints that expose different amounts of linguistic content to models across different languages. We instead ask what each encoding preserves when both the content and the downstream capacity are controlled. Using verified parallel sentences across thirteen languages and five scripts, we compare tokens, bytes, and pixels through a shared bottleneck whose width is swept to trace rate-utility frontiers. This separates three quantities that are often conflated: the number of input positions an encoding creates, the latent capacity available after encoding, and the task-relevant information that survives compression. We evaluate three utilities: surface form preservation, cross-lingual sentence alignment, and topic classification. No encoding dominates across tasks or capacity regimes. Pixels preserve surface form best, bytes preserve cross-lingual alignment best, especially in same-script multilingual settings, and tokens support topic prediction best. These performances are not explained by sequence length alone. Short inputs can discard useful mea

We study the problem of estimating locations in time at which the level of technology in an economy changes when given a sequence of time ordered inputs and outputs. We approach the problem through the lens of nonparametric frontier analysis with frontiers that expand sharply and globally over time, and develop an offline change point detection procedure which achieves the minimax localization rates for the problem at hand up to logarithmic factors. We additionally give a simple method for constructing confidence intervals for the unobserved change point locations. Finally, we explain how the procedure can be modified to accommodate local changes in technology, meaning that efficiency gains are only realized for certain combinations of inputs. Simulation studies and real data examples are also presented to illustrate the practical value of our methods.

Multi-modal neuroimaging projects are advancing our understanding of human brain architecture, function, connectivity using high-quality non-invasive data from many subjects. However, ground truth validation of connectivity using invasive tracers is not feasible in humans. Our NonHuman Primate Neuroimaging & Neuroanatomy Project (NHP_NNP) is an international effort (6 laboratories in 5 countries) to: (i) acquire and analyze high-quality multi-modal brain imaging data of macaque and marmoset monkeys using protocols and methods adapted from the HCP; (ii) acquire quantitative invasive tract-tracing data for cortical and subcortical projections to cortical areas; and (iii) map the distributions of different brain cell types with immunocytochemical stains to better define brain areal boundaries. We are acquiring high-resolution structural, functional, and diffusion MRI data together with behavioral measures from over 100 individual macaques and marmosets in order to generate non-invasive measures of brain architecture such as myelin and cortical thickness maps, as well as functional and diffusion tractography-based connectomes. We are using classical and next-generation anatomical t

Learning functional neuroanatomy requires forming mental representations of 3D structure, but forming such representations from 2D textbook diagrams can be challenging. We address this challenge in the UW Virtual Brain Project by developing 3D narrated diagrams, which are interactive, guided tours through 3D models of perceptual systems. Lessons can be experienced in virtual realty (VR) or on a personal computer monitor (PC). We predicted participants would learn from lessons presented on both VR and PC devices (comparing pre-test/post-test scores), but that VR would be more effective for achieving both content-based learning outcomes (i.e test performance) and experience-based learning outcomes (i.e., reported enjoyment and ease of use). All participants received lessons about the visual system and auditory system, one in VR and one on a PC(order counterbalanced). We assessed content learning using a drawing/labeling task on paper (2D drawing) in Experiment 1 and a Looking Glass autostereoscopic display (3D drawing) in Experiment 2. In both experiments, we found that the UW Virtual Brain Project lessons were effective for teaching functional neuroanatomy, with no difference betwee

Robotic exploration in large-scale environments is computationally demanding due to the high overhead of processing extensive frontiers. This article presents an OctoMap-based frontier exploration algorithm with predictable, asymptotically bounded performance. Unlike conventional methods whose complexity scales with environment size, our approach maintains a complexity of $\mathcal{O}(|\mathcal{F}|)$, where $|\mathcal{F}|$ is the number of frontiers. This is achieved through strategic forward and inverse sensor modeling, which enables approximate yet efficient frontier detection and maintenance. To further enhance performance, we integrate a Bayesian regressor to estimate information gain, circumventing the need to explicitly count unknown voxels when prioritizing viewpoints. Simulations show the proposed method is more computationally efficient than the existing OctoMap-based methods and achieves computational efficiency comparable to baselines that are independent of OctoMap. Specifically, the Bayesian-enhanced framework achieves up to a $54\%$ improvement in total exploration time compared to standard deterministic frontier-based baselines across varying spatial scales, while gu

Defining interdisciplinary physics today requires first a reformulation of what is physics today, which in turn calls for clarifying what makes a physicist. This assessment results from my forty year journey arguing and fighting to build sociophysics. My view on interdisciplinary physics has thus evolved jumping repeatedly to opposite directions before settling down to the following claim: today physics is what is done by physicists who handle a problem the "physicist's way". However the training of physicists should stay restricted to inert matter. Yet adding a focus on the universality of the physicist approach as a generic path to investigate a topic. Consequently, interdisciplinary physics should become a cabinet of curiosities including an incubator. The cabinet of curiosities would welcome all one shots papers related to any kind of object provided it is co-authored at least by one physicist. Otherwise the paper should uses explicitly technics from physics. In case a topic gets many papers, it would be moved to the incubator to foster the potential emergence of a new appropriate subfield of physics. A process illustrated by the subsection social physics in Frontiers in physic

Benchmarking the performance of complex systems such as rail networks, renewable generation assets and national economies is central to transport planning, regulation and macroeconomic analysis. Classical frontier methods, notably Data Envelopment Analysis (DEA) and Stochastic Frontier Analysis (SFA), estimate an efficient frontier in the observed input-output space and define efficiency as distance to this frontier, but rely on restrictive assumptions on the production set and only indirectly address heterogeneity and scale effects. We propose Geometric Manifold Analysis (GeMA), a latent manifold frontier framework implemented via a productivity-manifold variational autoencoder (ProMan-VAE). Instead of specifying a frontier function in the observed space, GeMA represents the production set as the boundary of a low-dimensional manifold embedded in the joint input-output space. A split-head encoder learns latent variables that capture technological structure and operational inefficiency. Efficiency is evaluated with respect to the learned manifold, endogenous peer groups arise as clusters in latent technology space, a quotient construction supports scale-invariant benchmarking, and

A principal screens an agent with an arbitrary set of allocations $X$. The agent's preferences over allocations are comonotonic. A subset of allocations $X^*\subseteq X$ is a surplus-elasticity frontier if (i) any other allocation has a demand curve that is pointwise lower and less elastic than some allocation in $X^*$ and (ii) the allocations in $X^*$ can be ordered in terms of their demand curves such that a higher demand curve is more inelastic. We show that any surplus-elasticity frontier is an optimal menu. Moreover, if the incremental demand curves along the frontier are also ordered by their elasticities, then the frontier is optimal even among stochastic mechanisms. The result is agnostic to type distributions and redistributive welfare weights -- the same frontier remains optimal for a broad class of objectives. As applications, we show how these results immediately yield new insights into optimal bundling, optimal taxation, sequential screening, selling information, and regulating a data-rich monopolist.

This paper introduces the necessary and sufficient conditions that surrogate functions must satisfy to properly define frontiers of non-dominated solutions in multi-objective optimization problems. These new conditions work directly on the objective space, thus being agnostic about how the solutions are evaluated. Therefore, real objectives or user-designed objectives' surrogates are allowed, opening the possibility of linking independent objective surrogates. To illustrate the practical consequences of adopting the proposed conditions, we use Gaussian processes as surrogates endowed with monotonicity soft constraints and with an adjustable degree of flexibility, and compare them to regular Gaussian processes and to a frontier surrogate method in the literature that is the closest to the method proposed in this paper. Results show that the necessary and sufficient conditions proposed here are finely managed by the constrained Gaussian process, guiding to high-quality surrogates capable of suitably synthesizing an approximation to the Pareto frontier in challenging instances of multi-objective optimization, while an existing approach that does not take the theory proposed in conside

This paper analyzes a model in which an outcome equals a frontier function of inputs minus a nonnegative unobserved deviation. The inputs may be endogenous (statistically dependent on the deviation). If zero lies in the support of the deviation given the inputs -- an assumption we term assignment at the frontier -- then the frontier is identified by the supremum of the outcome given those inputs, obviating the need for instruments. We then consider estimation with random error that is mean-independent of the inputs. Motivated by the assignment at the frontier assumption, we regularize estimation by requiring the fitted distribution of the deviation to maintain a minimum probability mass in a neighborhood of zero. Finally, we derive a lower bound on mean deviation, using only variance and skewness, that is robust to scarcity of data near the frontier. We apply our methods to estimate a frontier production function and mean inefficiency.

Despite numerous achievements and recent progress, nuclear physics is often (wrongly) considered an old field of research nowadays. However, developments in theoretical frameworks and reliable experimental techniques have made the field mature enough to explore many new frontiers. In this regard, extending existing knowledge to an emerging field of physics -- where particles interact with a relatively low-energy but high intensity field (intense enough so that multi-particle processes become comparable or more important than one-to-one processes) -- can lead to exciting discoveries. Investigations can be realized under a highly time-compressed beam source (e.g., particle sources generated by laser-matter interaction using high-power laser systems). Here we focus on a new scheme, where high-power laser systems are exploited as a driver to generate energetic ($γ$-ray) photons. Together with additional low-energy photons provided by a second, less intense laser, a multi-photon absorption scheme enables a very attainable manipulation of nuclear transitions including isomer pumping and depletion.

This paper provides identification results to characterize a fairness-accuracy (FA) frontier, and statistical inference tools to test hypotheses and build a confidence set for the FA-frontier, when outcomes are observed only for selected individuals. When the selection process is unrestricted but loss is measured in specific ways, we provide a characterization of the sharp identification region of the FA-frontier. Under an assumption of unconfoundedness conditional on observables (and unrestricted loss functions), we obtain point identification and propose a debiased machine learning estimator, derive its asymptotic distribution, and show how this can be used to carry out inference for the FA-frontier. In work in progress, we extend the partial identification results to a broader class of loss functions.

We identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current approaches to research in melanoma and the dermatological sciences. We focus on four themes: (1) clinical melanoma research, (2) basic melanoma research, (3) clinical dermatology, and (4) basic pigment cell research, with the goal of outlining current highlights, challenges, and frontiers associated with pigmentation and melanocyte biology. Significantly, this document encapsulates important advances in melanocyte and melanoma research including emerging frontiers in melanoma immunotherapy, medical and surgical oncology, dermatology, vitiligo, albinism, genomics and systems biology, epidemiology, pigment biophysics and chemistry, and evolution.

The trade off between risks and returns gives rise to multi-criteria optimisation problems that are well understood in finance, efficient frontiers being the tool to navigate their set of optimal solutions. Motivated by the recent advances in the use of deep neural networks in the context of hedging vanilla options when markets have frictions, we introduce the Efficient Hedging Frontier (EHF) by enriching the pipeline with a filtering step that allows to trade off costs and risks. This way, a trader's risk preference is matched with an expected hedging cost on the frontier, and the corresponding hedging strategy can be computed with a deep neural network. We further develop our framework to improve the EHF and find better hedging strategies. By adding a random forest classifier to the pipeline to forecast market movements, we show how the frontier shifts towards lower costs and reduced risks, which indicates that the overall hedging performances have improved. In addition, by designing a new recurrent neural network, we also find strategies on the frontier where hedging costs are even lower.