To investigate whether i) ultrasonographically-assessed carotid arterial disease (CAD) is associated with diabetic retinopathy (DR) progression and retinal microangiopathy measured by optical coherence tomography angiography (OCTA), and ii) baseline DR prevalence and/or OCTA parameters are associated with CAD progression in type 2 diabetes. Participants in the Fremantle Diabetes Study Phase II (n = 164, mean age 69.7 years, 55.5% males) in whom carotid ultrasonography/OCTA was performed in 2018-2019 were restudied a mean 3.7 years later. Generalized estimating equations assessed associations between baseline CAD indices and new/worsening DR and OCTA parameter changes, and between baseline DR status/OCTA parameters and changes in CAD metrics. Carotid stenosis (focal wall thickening ≥50% or intima-media thickness (IMT) > 1.5 mm) and carotid bifurcation IMT ≥1 mm at baseline were independently associated with reductions in superficial capillary plexus parafoveal vessel density (regression coefficients (95% CI) 0.73 (0.02 to 1.43) and 0.88 (95% CI: 0.06 to 1.69); P = 0.043 and 0.035, respectively). There were no independent associations between CAD parameters and new/worsening DR. There were no significant associations between baseline DR/OCTA parameters and new/worsening carotid stenosis. CAD may contribute to early DR in type 2 diabetes but we found no evidence of a bidirectional relationship.
The temporomandibular joint is anatomically and neurologically associated with the cervical spine. The aim of this study was to investigate the impact of temporomandibular disorder on neck awareness, cervical sensorimotor performance, and pain sensitivity, including pressure pain threshold, pressure pain tolerance, and temporal summation. In this observational, cross-sectional study, the diagnostic criteria for temporomandibular disorders were used to evaluate temporomandibular disorder. Trial registered as NCT06558318. Participants were divided into two groups based on temporomandibular disorder presence: a temporomandibular disorder group (n=25) and an asymptomatic control group (n=25). Neck awareness was evaluated using the Fremantle Neck Awareness Questionnaire, while cervical sensorimotor performance was assessed using the "joint position error test" for both the global cervical region and the isolated upper cervical region, measured separately with a cervical range of motion device. Pain pressure threshold, pain pressure tolerance, and temporal summation were measured using a mechanical pressure algometer. No significant differences were found between the temporomandibular disorder and control group in pain-related parameters (p>0.05). Neck awareness was significantly impaired in the temporomandibular disorder group (p<0.001), although the joint position error tests showed no significant differences (p>0.05). The presence of temporomandibular disorder did not affect pain sensitivity in the cervical region. While sensorimotor performance was not impaired in either the global or the isolated upper cervical region, neck awareness was affected in the temporomandibular disorder group. This suggests that neck awareness in patients with temporomandibular disorder should be considered in clinical evaluation and management.
Police force recruits have a high musculoskeletal injury burden, which results in a substantial economic burden and can lead to attrition. The objective of this study was to identify and prioritise the strategies perceived as important and feasible to reduce the prevalence, incidence, and burden of injury in police force recruits. Mixed-methods concept mapping study. Forty-eight participants were recruited from four broad groups: police force recruits/officers; police force staff; health professionals; and research experts. Participants brainstormed statements in response to a prompt ("To prevent injury and/or reduce the impact of injury on law enforcement recruit training, I think it's important to….") before sorting and rating the statements/strategies for importance and feasibility. Descriptive statistics, multi-dimensional scaling, hierarchical cluster analysis, pattern matching and Welch's t-tests were applied. Ninety-six unique prevention strategies were identified (42 were above the grand mean for both importance and feasibility). Eight clusters appropriately represented all statements. From highest to lowest mean cluster importance these were: i) clearly communicate physical training program expectations and requirements; ii) prepare for, monitor and manage physical training load; iii) provide best practice injury identification, prevention and management; iv) educate recruits, staff and other stakeholders involved in academy training delivery; v) provide a supportive training environment that promotes health, wellbeing and injury reporting; vi) have experienced staff deliver training and use appropriate equipment; vii) deliver a comprehensive and holistic physical training program; and viii) have appropriate physical entry standards and requirements. We identified 42 strategies above the grand means for both importance and feasibility to reduce the burden of injury in police force recruits. These strategies can be implemented by recruits, staff delivering the training program, and/ or staff managing or governing the training program. Future research should refine how these strategies can be implemented in practice and policy.
Alterations in neuromotor function occur following lower-limb injuries and might be a factor in recurrent injury. We evaluated if adults with previous lower-limb muscle or tendon injury demonstrate differences in neuromotor function compared with uninjured or control limbs. A systematic search of health databases MEDLINE, EMBASE, CINAHL, and SPORTDiscus was conducted from inception until the end of April 2024. Studies evaluating neuromotor function of adults with a history of lower-limb muscle or tendon injury compared to an uninjured contralateral or control limb were included. Inverse variance, random effects meta-analyses were used to generate effect estimates for neuromotor outcomes. A best evidence synthesis determined the level of evidence (LOE) and summary estimates for changes in neuromotor function. Sixty-three studies (1 796 participants) were included, with injuries to Achilles, gluteal and patella tendons and adductor, calf, hamstring and rectus femoris muscles. Below one quarter (21%) of 232 neuromotor outcomes identified were amenable to data pooling. Evidence for changes in neuromotor function were found, notably, a reduction in lateral hamstring activation during isokinetic contractions (LOE: strong) and knee joint position sense (2 studies: control SMD ​= ​1.11, 95% CI = [0.61, 1.61]; p ​< ​0.000 1; 2 studies: uninjured SMD ​= ​0.98, 95% CI = [0.37, 1.58]; p ​= ​0.002; LOE: strong) in hamstring strain injury. Differences in neuromotor function were present in injured compared to control and uninjured limbs, including reduced muscle activation and proprioception in hamstring muscle injury. Methodological diversity was common, however, and variable results were found. As such, the overall impact of lower-limb muscle or tendon injury on neuromotor function remains uncertain.
While human malaria transmission in Indonesia has declined, reported cases of zoonotic Plasmodium knowlesi are increasing. This study examined the larval habitats of malaria vectors in North Sumatra to assess the potential of larval source management as a control strategy for both human and zoonotic malaria vectors. Multiple larval habitat surveys in the areas surrounding two dusuns with documented human and zoonotic (P. knowlesi) malaria cases in Langkat Regency, North Sumatra, were conducted over 2 years, encompassing both wet and dry seasons. Larval habitats were characterized by mosquito immature presence and density, land-use type where found, aquatic habitat class (i.e., naturally occurring, man-made from natural materials or man-made from artificial materials), and habitat subclass for a range of abiotic and biotic parameters. A total of 1413 mosquito larvae and 98 pupae were collected. Anopheles larvae comprised 20.6% of all mosquito immatures. Anopheles maculatus comprised 65.3% of all immature anophelines, followed by Anopheles dirus (21.9%), Anopheles scanloni, Anopheles kochi, and Anopheles vagus in order of abundance. Habitat class predicted anopheline presence and density, with larvae occurring more frequently in naturally occurring habitats and man-made habitats from natural materials than in artificial man-made habitats (presence: generalized linear mixed model [GLMM] β =  -1.45, P = 0.006; density: β =  -1.42, P = 0.001). At the habitat subclass level, An. maculatus larvae were most frequently detected in natural habitats, particularly stream margins. Meanwhile, An. dirus larvae occurred approximately equally in natural habitats and man-made habitats from natural materials, with tire tracks being the most common habitat subclass. Four species (An. maculatus, An. dirus, An. scanloni, and An. kochi) were detected, albeit infrequently, in man-made habitats from artificial materials. In North Sumatra, anopheline vector species utilize a diverse range of larval habitats, including natural and man-made, on both natural substrates and artificial materials. Species-specific habitat preferences were observed: An. dirus was found in both natural and man-made habitats from natural materials, whereas An. maculatus was predominantly found in more dispersed and inaccessible natural sites, suggesting that larval control may be more challenging for An. maculatus than An. dirus.
Chronic pelvic pain (CPP) affects 20% of women worldwide and is associated with substantial disability, yet its mechanisms remain unclear. Alterations in sensory or motor processing, and body perception, have been implicated in chronic pain conditions but the evidence has not been formally synthesised in CPP. This scoping review mapped the evidence for altered sensory function, motor function or body perception disturbance (BPD) in women with CPP. We searched multiple databases (up to April 2025) for studies of any design that explored these elements in women with CPP. We included 175 studies (19,457 participants). Most studies compared sensory and motor function with healthy controls, using quantitative sensory testing to assess sensory function, while a small group indirectly investigated BPD in this population. Pain-evoking sensory tests in the pelvic region consistently demonstrated reduced thresholds in people with CPP. Findings from remote body regions were less consistent, though evidence of widespread hypersensitivity and altered pain modulation suggested potential central involvement. Motor testing was limited and inconsistent. Central nervous system studies showed heterogeneous findings across conditions, including altered brain activity and evidence of altered sensorimotor processing. In qualitative studies, women described disconnection from, altered awareness of, and lack of perceived control over the pelvic region. Across all studies methods varied, with highly variable protocols and incomplete reporting limiting comparisons. Collectively, findings suggest emerging but inconsistent evidence for sensory, motor and body perception alterations in CPP. Future research should establish a theoretical framework, standardise methods and reporting, and integrate sensory, motor, and perceptual domains. PERSPECTIVE: Altered sensory function in the affected region is consistently reported in female CPP. Evidence of enhanced sensitivity in other body regions, motor changes, or changes in central nervous system structure and function is limited and inconsistent. Future research should establish a clearer conceptualisation of BPD, develop standardised methods and reporting.
Background: Poor or rapid growth velocity in early childhood can have negative long-term health consequences. Early identification of children at risk of growth problems facilitates timely intervention to change growth trajectories and health parameters, but barriers exist to routine screening in primary care. Methods: Experts from general practice, primary care nursing, pediatrics, dietetics, and academic research convened to develop a practical algorithm to support routine growth screening and intervention in children aged 1 to 5 years in primary care. Results: Using a single initial measurement of weight and height in conjunction with risk factor assessment, the algorithm presented here identifies children at risk of poor or rapid growth velocity and provides guidance for intervention and follow-up frameworks. Conclusions: This tool helps to define children in the community setting who are at risk of poor or rapid growth velocity and supports primary care providers in promoting healthy growth trajectories through timely intervention and continued routine growth monitoring.
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Preterm birth remains a leading cause of newborn death, disability, and long-term health challenges globally, with a substantial impact on families, the health system, and society. Omega-3 supplementation in women with low omega-3 status in early pregnancy has been shown to reduce the risk of preterm birth, particularly early preterm birth (<34 weeks of gestation). The cost implications of incorporating omega-3 testing and targeted supplementation into routine antenatal care to reduce early preterm birth in Australia are unclear. A decision analytic model was developed using Australian epidemiological, clinical, and cost data to compare routine omega-3 testing and targeted supplementation with current practice. The model predicted the number of early preterm births prevented and associated cost savings over an 18-year time horizon. Deterministic sensitivity analyses were conducted to examine uncertainty in key model inputs. Among 289,195 singleton pregnancies in 2022, an estimated 17.5% of women would have low omega-3 status and be eligible for supplementation. Making conservative assumptions, the model predicted that, relative to current practice, omega-3 testing and supplementation would be a dominant strategy, preventing 640 early preterm births, with projected savings of $26.1 million in direct healthcare costs. Sensitivity analyses indicated that the results were robust across most scenarios and identified the treatment effect estimate as the strongest driver of model predictions. Omega-3 testing in early pregnancy with targeted supplementation may offer a scalable and cost-effective strategy to reduce early preterm birth with potential benefits for mothers, infants, and the health system. The modelling suggests meaningful health and economic benefits. Cost savings were robust across most plausible scenarios, supporting the potential value of this approach on a national scale. Every year, thousands of babies in Australia are born too early, putting them at risk of serious health problems and placing a heavy burden on families and the health system. Babies born before 34 weeks of pregnancy face the greatest risks of death, intensive care, long hospital stays, and lifelong challenges. Evidence shows that omega-3 supplementation lowers the risk of preterm birth for women with low omega-3 levels, and this recommendation was included in Australia’s National Pregnancy Care Guidelines. We assessed whether introducing a simple omega-3 blood test and offering high-dose supplements to women with low levels, as part of routine pregnancy care, would be cost-effective. Using Australian data, we built a model to compare this approach with current care. Under conservative assumptions, the model predicted that testing and targeted supplementation could prevent about 640 births before 34 weeks of gestation each year and save $26 million in direct healthcare costs and $44.7 million overall. For every dollar invested, the health system could save $1.67 in direct costs and $3.00 in total costs. Adding omega-3 testing with targeted supplementation to routine pregnancy care has the potential to improve outcomes for mothers and babies while reducing healthcare costs substantially. This is an affordable, evidence-based change that could deliver significant benefits nationwide.
Tick bites in Australia are associated with a poorly understood syndrome known as Debilitating Symptom Complexes Attributed to Ticks (DSCATT), however, the underlying biological mechanisms remain unclear. Here, we investigate host responses to tick bite and DSCATT by profiling circulating host-encoded microRNAs (miRNAs), key regulators of gene expression. Circulating miRNAs were profiled in two cohorts: a longitudinal cohort followed from tick bite for up to 12 months, and a retrospective cohort with DSCATT. Differential expression analysis revealed that tick bite induces widespread changes in circulating miRNAs, with 149 miRNAs showing significant variation over 12 months. Temporal clustering revealed two expression patterns: one oscillating trajectory and a declining then stabilising, with predicted targets enriched for pathways related to immune modulation, tissue remodelling and cellular stress responses. DSCATT patients exhibited 98 differentially expressed miRNAs, including significant overlap with acute tick bite miRNAs, and four miRNAs correlated with symptom severity, including fatigue and dizziness. Machine learning analysis identified a five-miRNA signature that classified acute tick bite with 86% accuracy and receiver operating characteristic area under the curve (ROC AUC) of 0.92. These findings represent, to the best of our knowledge, the first characterisation of host miRNA responses to tick bite and DSCATT, highlighting potential biomarkers and mechanisms underlying chronic symptom development.
There is considerable evidence that an inflated tendency to have negative rather than benign expectancies concerning upcoming situations contributes to heightened trait anxiety. To date, the cognitive mechanisms that underpin this anxiety-linked negative expectancy bias remain unknown. In a separate line of research, it has been established that heightened trait anxiety is characterised by an attentional bias to negative information. While it is possible that these two types of bias independently contribute to elevated trait anxiety an interesting alternative possibility is that attentional bias to negative information may contribute to negative expectancy bias, which in turn contributes to elevated trait anxiety. In order to distinguish the validity of these two possibilities, the current study employed a novel methodological approach in which participants were exposed to an attentional task which presented emotionally valenced information relevant to an upcoming situation. Participants' attentional bias towards negative relative to benign information was assessed, as was their expectancy bias concerning the relative negativity of this upcoming situation. As anticipated, negative attentional bias and negative expectancy bias both correlated with trait anxiety. However, the association between negative attentional bias and trait anxiety was indirect, and this association was significantly mediated by negative expectancy bias. Thus, the findings support the hypothesis that attentional bias to negative information contributes to negative expectancy bias, which in turn contributes to elevated trait anxiety.
This study aims to identify commonly utilised self-managed non-pharmacological interventions for managing post-treatment ULD among breast cancer survivors, evaluate their effectiveness and safety, and identify the research gaps for future studies. A systematic review was conducted, and eight English databases (PubMed, Cochrane Library, Embase, CINAHL, Web of Science, Scopus, PsycINFO, and ProQuest) were searched from their inception to 30 September 2025. Google and ResearchGate were also searched to identify any additional eligible studies. Narrative synthesis was used for data analysis. Risk of Bias version 2 was used to assess the quality of the included studies. 5972 studies were identified by initial research, and eight studies were finally included. Commonly utilised self-managed non-pharmacological interventions for managing post-treatment ULD among breast cancer survivors were exercise-based strategies. Three studies reported a statistically significant effect on improving post-treatment ULD, and five studies reported unexpected events during interventions. Regarding the methodological quality, five studies had some concerns, and three had a high risk of bias. Self-managed non-pharmacological interventions for post-treatment ULD in breast cancer survivors are predominantly exercise-based. However, evidence regarding their effectiveness and safety remains inconclusive due to the limited number, heterogeneity, and methodological limitations of existing studies. Notably, evidence on non-exercise self-managed approaches is lacking. Low-intensity, structured exercise programs incorporating upper limb stretching and movement-based exercises may represent a feasible self-managed option for improving upper limb function. INPLASY2025110066 (https://doi.org/10.37766/inplasy2025.11.0066). INPLASY2025110066 (https://doi.org/10.37766/inplasy2025.11.0066).
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Optimizing guideline-directed medical therapy (GDMT) remains vital for heart failure (HF) management. However, non-labelled dosing of sacubitril-valsartan is increasingly reported.This global survey characterized real-world sacubitril-valsartan prescribing patterns and evaluated pharmacist involvement in HF teams. The validated 26-item IKNOW-HF survey was disseminated globally to clinicians treating patients with HF. Participation was voluntary and anonymous. Out of 1829 responses from 76 countries, 1285 (70.3%) were complete, predominantly from cardiologists 1031 (80.2%). Non-labelled sacubitril-valsartan dosing was reported by 1107 (86.1%) respondents, heavily driven by general cardiologists 326 (90%) and clinicians in the low- and lower-middle-income countries 195 (96%). Predictors of non-labelled dosing included practicing in Asia [odds ratio (OR) 0.347; 95% confidence interval (CI) (0.214-0.563)] and having over 10 years of experience [OR 0.695; 95% CI (0.489-0.990)]. The presence of a cardiology pharmacist trended towards a fewer non-labelled prescriptions [OR 0.542; 95% CI (0.283-1.039), P-value = 0.065], whereas management by HF specialist trended towards increased non-labelled usage [OR 1.443; 95% CI (0.981-2.122), P-value = 0.063]. The IKNOW-HF survey reveals a substantial variation between guideline-recommended and real-world prescribing practices, with over 80% of responding clinicians utilizing non-labelled dosing. The higher prevalence among HF specialists likely reflects a pragmatic salvage strategy for advanced HF patients intolerant to standard target doses. These findings highlight the need for further education, pragmatic clinical trials evaluating real-world dosing outcomes, and broader integration of specialized pharmacists to optimize GDMT.
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This study aimed to determine perceptions of the oncology nursing role and workplace challenges among oncology nurses working in Australia and Türkiye. This cross-sectional comparative study used convenience sampling of from oncology nursing societies in Australia and Türkiye. Recruitment occurred via electronic invitations and social media. Participants (Australia: n = 846; Türkiye: n = 191) included registered nurses in clinical oncology; nonclinical roles were excluded. Data were collected using the translated and expert-validated Cancer Nursing Workforce Survey. Statistical analysis involved descriptive statistics and Pearson chi-square tests on dichotomized Likert-scale responses using SPSS. A total of 1,037 oncology nurses participated. Over 50% of Australian and Turkish nurses reported high workload and information overload as key workplace challenges. Most Turkish nurses (>50%) reported the following items as workforce challenges: difficulties integrating digital health technologies, restricted career progression, lack of training opportunities, unclear role expectations, ineffective interagency collaboration, and low staff motivation. Confidence in core clinical competencies was high in both countries. No significant differences were observed in confidence related to comprehensive cancer care, physical and psychological symptom management, autonomy, or peer and educational support. However, Turkish nurses reported higher confidence in managing spiritual distress, while Australian nurses reported clearer scopes of practice and greater access to professional development (P < .001). Oncology nurses in Türkiye and Australia reported high clinical confidence, with Turkish nurses expressing greater confidence in spiritual care and Australian nurses reporting clearer scopes of practice. High workload was a shared challenge, while Turkish nurses identified more structural barriers related to career progression, leadership support, and staff motivation, indicating that workforce experiences reflected system-level and career-related factors rather than individual competence. Tailored workforce strategies are required to strengthen leadership, professional development, role clarity, and resource allocation to support sustainable oncology nursing practice across diverse healthcare systems.
Paracetamol may improve renal function in patients with severe Plasmodium knowlesi malaria, particularly in those with acute kidney injury and hemolysis, via inhibition of cell-free hemoglobin mediated oxidative kidney damage. We developed a population pharmacokinetic/pharmacodynamic (PK/PD) model to assess effects of paracetamol on creatinine, hepatotoxicity, fever clearance, and parasite clearance among Malaysian patients with predominantly non-severe knowlesi malaria using data from the PACKNOW trial (Clinical Trials Registration: NCT03056391). A total of 372 patients were included in the PK/PD analyses (paracetamol: n = 183, control: n = 189). Paracetamol PK was described using a prior PK model published in patients with falciparum malaria. The PK/PD demonstrated that higher paracetamol exposures were associated with a faster decline in both creatinine and fever clearance time, supporting its renoprotective and antipyretic effects. Increased paracetamol exposure was not associated with hepatotoxicity or serious adverse events, despite a weak positive association with liver transaminases over time. No significant relationship was observed between paracetamol exposure and parasite clearance. Overall, these findings highlight an exposure-response relationship for paracetamol and a decline in creatinine, supporting its use as a renoprotective drug in treating Plasmodium knowlesi malaria.
Grief is typically conceptualized as an individual process, yet it unfolds within families and is shaped by its dynamics. We conducted a systematic review to synthesize evidence examining how family dynamics influence grief responses. A pre-registered review (PROSPERO registration: CRD420251061451) was conducted in accordance with PRISMA guidelines. Four databases (CINAHL, Scopus, PsycINFO, Medline) and gray literature were searched to identify studies that reported original data, involved two or more members of multiple families, and focused on post-death grief, with the last search in June 2025, yielding 7,806 records. Twenty-nine studies met inclusion criteria and methodological quality was assessed. Findings were narratively synthesized into four themes: communication and cohesion, caregiver influence on child adjustment, roles and reorganization, and cultural and societal influence. Evidence was limited by self-report measures, retrospective data, and cross-sectional designs. Findings suggest that addressing family dynamics in clinical practice, community programs, and policy may promote healthier adaptation following bereavement.
The SPHInX study is the first-ever randomized controlled trial (RCT) seeking to inform an area of equipoise regarding the efficacy of oral anticoagulation as adjunct therapy in systemic sclerosis-related pulmonary arterial hypertension (SSc-PAH). The SPHInX study was an Australian multicenter, double-blind Phase III RCT of 1:1 oral apixaban 2.5 mg twice daily versus placebo over 3 years, as additional therapy in patients with SSc-PAH. The primary end-point was time to clinical worsening (TtCW), or death. A sample size of 85 per arm was required to show a two-fold reduction in TtCW. Participants experiencing clinical worsening events continued in the study, allowing for assessment of exploratory endpoints (including physical function and quality of life measures) up until 3 years of treatment. Among 11 SSc-PAH participants assigned apixaban treatment and 14 participants assigned placebo, apixaban demonstrated no benefit compared to placebo for TtCW from commencement until 30 days after discontinuation of study drug, Cox proportional hazard ratio 0.92 (95% confidence interval 0.32-2.66), p = 0.88. There was no difference between treatment groups in event-free survival, all-cause mortality, or exploratory endpoints. New iron deficiency anemia occurred in 9 (81.8%) apixaban treated participants compared to 4 (28.6%) controls. Although strict selection criteria in a complex disease meant recruitment was insufficient for the primary efficacy endpoint, the SPHInX RCT showed no signal for benefit with anticoagulation as adjunct therapy, with a high frequency of iron deficiency anemia suggesting that even at low doses, risk may outweigh benefit with anticoagulation in SSc-PAH. Trial Registration: Australian New Zealand Clinical Trials Registry Registration Number: ACTRN12614000418673 (http://www.ANZCTR.org.au/ACTRN12614000418673.aspx).
Native joint septic arthritis (NJSA) requires joint excision and arthroplasty when debridement fails or irreversible joint damage is present. Traditionally, this is performed as a staged procedure with a spacer and antibiotics prior to definitive arthroplasty. While effective, this approach is associated with multiple operations, prolonged treatment, and increased morbidity. The 1.5-stage arthroplasty has recently emerged as a potential alternative in treating periprosthetic joint infections, but its role in NJSA remains unexplored. This study evaluated the clinical outcomes of 1.5-stage arthroplasties in hips and knees for NJSA. A retrospective analysis was conducted on patients who underwent a 1.5-stage (n = 45) arthroplasty for NJSA between 2015 and 2024. Primary outcome was the revision rate at 12 months postoperatively. Secondary outcomes included surgical complication rates, length of hospital stay, rate of progression to second stage, 30-day emergency department and hospital readmission rates, and 1-year mortality. At 1 year, the revision rate was 26.7%, with only 2 revisions performed for surgical complications (6.7%). Overall, 24.4% of patients progressed to a planned second stage within 1 year, primarily for functional optimization. The median length of stay was 13.5 days (interquartile range: 8-16). Thirty-day emergency department presentations (11.1%), readmissions (6.7%), and 1-year mortality (4.4%) were low and did not differ between hip and knee cohorts. No baseline demographic or clinical factors were significantly associated with revision risk. These findings suggest that 1.5-stage arthroplasty is a safe and effective option for NJSA, potentially avoiding additional surgery in selected patients.