The integration of biological networks provides crucial support for accurate gene function prediction, a task that aims to assign genes to corresponding functional categories through computational methods. However, existing approaches struggle with multi-source heterogeneous networks due to their limited ability to capture complex nonlinear dependencies. Contrastive learning, which captures data distributions by measuring similarities and dissimilarities between samples, can generate semantically rich feature representations, offering a new approach to address the aforementioned issues. In this work, we propose EPILOGUE, a multi-view graph contrastive learning framework for gene function prediction. By integrating graph neural networks with contrastive learning, EPILOGUE enables the extraction of high-quality, discriminative gene representations for accurate functional annotation. Additionally, protein sequences are used as node features, offering biological information beyond network topology and supporting the learning of comprehensive semantic representations. Experiments on yeast and human datasets from the STRING database demonstrate that EPILOGUE outperforms nine state-of-the-art methods across six evaluation metrics, validating its effectiveness in learning semantically rich representations for gene function annotation.
This epilogue reviews key concepts and summarizes the seven articles presented in the forum focused on addressing childhood trauma and maltreatment through the lens of the International Classification of Functioning, Disability and Health (ICF) framework. Each of these articles presents information relevant to how the occurrence and subsequent effects of trauma and maltreatment can be conceptualized, realized, and mitigated. At its essence, this forum provides a collection of articles that underscore how to provide contextualized care by considering environment, social factors, individual characteristics, and so forth, as opposed to focusing on treatment in insolation. While different approaches are discussed, this epilogue highlights the central theme of the ICF and how speech-language pathologists can apply this framework to provide compassionate trauma-informed care to children with communication disorders who have experienced trauma and/or maltreatment.
This epilogue considers the approach and conception of this collection, highlighting key analytical strands in the essays while also suggesting possible avenues of further research. It spotlights the global nature of their analysis, which offers one structural framework - individual scientific personas and the often transnational networks which they inhabit - as a possible avenue to imagine a so-called global Space Age. The epilogue also investigates possible frames for further analyses, particularly regarding gender and translation. Men dominate the pantheon of space personas, which, I argue, is a function of the way popular discourses about space travel are still dominated not only by patriarchal and often misogynistic tropes, but also by how we define 'technology' itself as essentially a male domain of activity. More broadly, we need further investigation of multiple and gendered erasures involved in the creation of male space personas. Similarly, the kinds of tools, work and strategies the space personas deployed to translate their visions across different social, discursive, cultural and temporal domains require attention. In particular, one can imagine that the afterlife of these personas will be susceptible to change and alteration as their messages, reputations, and principal attachments are continually reshaped by historical change, popular culture, and academic currents.
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Wars have profound effects on well-being, but what about the ending of war? This study investigates this topic using representative samples of 4127 Afghans living through the latter stages of the War in Afghanistan and its aftermath. We find that the life satisfaction of Afghans dropped significantly following the conclusion of the War in Afghanistan in 2022, with two-thirds reporting a life satisfaction rating of 0 or 1 on a 0-to-10-point scale. When compared to data from two international well-being datasets together covering more than 170 countries between 1946 and 2022, the mean life satisfaction score in Afghanistan following the Taliban regaining power (M = 1.28) is the lowest ever recorded. The mean hope score in the country also dropped to a critically low level (M = 1.02) in 2022. Wars are devastating, but the conclusion of war can appear worse from the perspectives of civilians despite the de-escalation of physical violence.
Long term clinical studies are needed to confirm the usefulness of LEDs. Charcoal toothpaste with whitening power is a product that defies logic. One must fight discoloration by incorporating an ingredient that is dark in color. Again, controversies exist, and we are just introducing the readers to the possibility. One major US oral health product company has aggressively marketed such a product so there must be some magic behind the concept. One important issue concerning dental bleaching is that of public safety. To add to the confusion, the European Union regulations are much stricter than those in the USA. FDA classified dental bleaching as a cosmetic procedure and not under its supervision. We often see advertisements on cruise ships and shopping kiosks recruiting clients for "teeth whitening". They are careful with the terminology since according to the FDA, whitening restores natural tooth color and bleaching whitens beyond the natural color. Currently, there are multiple ongoing clinical studies and we will wait for conclusive clinical data to help guide us. Lastly, I would like to thank all the contributors and the editorial staff at the American Journal of Dentistry who were so patient with us through this process. Without them, the issue would not be possible.
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In this article I reflect on almost 40 years of clinical practice. I remember the first day like it was yesterday, and I remember the last day, but the in between represents my soul, a soul that has been shaped by countless experiences. Some of these experiences were immediately impactful and left an indelible mark on my soul, but most of them were memorable only for a fleeting moment, soon to be forgotten. Yet the cumulation of these seemingly trivial experiences, in retrospect, served as the foundation of my career at Kaiser Permanente.
In mid-March 2020, the Kerala government implemented additional preventive measures to the steps already taken to reduce the transmission of COVID-19. Strategies were taken by a non-governmental palliative care organisation (Pallium India) with Coastal Students Cultural Forum - a coastal area-based collective of young educated people in the coastal region to address the medical needs of people living in this community. The facilitated partnership lasted 6 months (July-December 2020) and addressed the palliative care needs of the community in the selected coastal regions during the first wave of the pandemic. Volunteers sensitised by the NGO identified more than 209 patients. The current article highlights the reflective narratives of key players in this facilitated community partnership. The current article is dedicated to highlighting the reflective narratives of key players in this facilitate community partnership to the readers of this journal. The palliative care team's overall experience was collected from selected key participants to understand the program's impact, identify areas of improvement, and discuss possible solutions if there were any challenges. The contents below are their statements on the experience of the entire program. Palliative care delivery programmes must be configured to respond to local needs and customs, be community-based and integrated with local health and social care and have accessible referral pathways between and across services. They must also be responsive to changing individual and population needs and shifts in local and national health structures.
This prologue introduces the Language, Speech, and Hearing Services in Schools forum, Addressing Childhood Trauma and Maltreatment Through the Lens of the ICF. The goals of the forum are twofold: first, to draw attention to the prevalence of children who have experienced trauma and maltreatment and how it affects their language and literacy development, and second, to provide an overview of the International Classification of Functioning, Disability and Health (ICF) framework and how it can be used to conceptualize assessment procedures and tailor interventions to meet the individual needs of the child while providing compassionate trauma-informed care. This prologue provides an overview of the prevalence of childhood trauma and how it affects children's language and literacy development. By extension, this prologue also underscores why speech-language pathologists (SLPs) should carefully consider this topic. Importantly, SLPs treat children in context, and although other professionals such as psychologists or social workers are the professionals expected to provide direct services in this area, SLPs still have an obligation to provide compassionate trauma-informed care, and they have expertise in areas that can support children in being able to better benefit from and participate in therapeutic treatments. To this point, this prologue also provides an overview of the ICF and provides examples of how the ICF may be used to support children with histories of trauma or maltreatment. As such, this prologue introduces the topics covered by seven articles as well as the epilogue. These articles cover reviews, tutorials, case studies, clinician development, and professional programming. Children who have experienced trauma or maltreatment are at an increased risk for experiencing neurological disruptions that affect their language and literacy development, which increases the likelihood SLPs will encounter children with these experiences on their caseloads. The articles included within this forum underscore the various ways children might be affected by traumatic experiences and how SLPs can use the ICF framework to identify barriers and facilitators when engaging in assessments and developing interventions.