In a retrospective study we analyzed the cases of 112 patients with erythema nodosum treated during the period 1983-1993 in the Department of Dermatology, University Hospital of Basel, Switzerland. The aim of the study was to investigate the epidemiology, incidence of different etiologies, relevance of laboratory investigations and the histopathologic features in our patients, 83% of whom were females. The peak incidence occurred between the ages of 18 and 34 years. The commonest cause of erythema nodosum was infection. Other etiologic factors were adverse drug reactions, sarcoidosis, Crohn's disease, non-Hodgkin lymphoma, pregnancy, discoid lupus erythematosus, Sharp syndrome and aspartame. Only 47% of patients showed the classic bilateral distribution of the nodes on the extensor surface of the lower extremities. 77% of infection-induced erythema nodosum healed after 7 weeks, the longest course being 18 weeks. In contrast, 30% of idiopathic erythema nodosum lasted more than 6 months. Patients in whom erythema nodosum was associated with non-Hodgkin lymphoma had an extremely protracted course. Erythema nodosum associated with non-Hodgkin lymphoma may precede the diagnosis of lymphoma by months. In 4 cases erythema nodosum was the initial sign of sarcoidosis. In 30% of biopsies we found single vessels with leukocytoclastic vasculitis. The histologic pattern failed to provide etiologic pointers.
Imatinib mesylate (STI 571; Gleevec; Novartis Pharmaceuticals, Basel, Switzerland) is an orally available tyrosine kinase inhibitor that targets a constitutively activated BCR-ABL tyrosine kinase with additional inhibitory effects on platelet derived growth factor (PDGF) receptors alpha and beta, and KIT. It has revolutionized the treatment of adult and pediatric patients with Philadelphia chromosome positive chronic myelogenous leukemia (CML) and is also FDA-approved for KIT-positive advanced gastrointestinal tumor (GIST) and dermatofibrosarcoma protuberans. A wide spectrum of dermatologic toxicities has been associated with this agent, among which a maculopapular rash is the most common event. In addition, a variety of pigmentary abnormalities of the skin and mucosal surfaces have been reported. Hypopigmentation is a well-recognized adverse effect. In contrast, paradoxical hyperpigmentation has only rarely been documented. In this case report we describe imatinib-induced cutaneous hyperpigmentation and graying of hair occurring in the same patient with dermatofibrosarcoma protuberans treated with imatinib.
Dermatologic TherapyVolume 33, Issue 4 e13774 Letter Virtual conferences of dermatology during the COVID-19 pandemic Mohamad Goldust, Mohamad Goldust orcid.org/0000-0002-9615-1246 Department of Dermatology and Allergy, University Hospital Basel, Basel, SwitzerlandSearch for more papers by this authorSwathi Shivakumar, Swathi Shivakumar orcid.org/0000-0002-4497-7687 Consultant Dermatologist, Cosmetiq Clinic, Thiruvananthapuram, Kerala, IndiaSearch for more papers by this authorGeorge Kroumpouzos, George Kroumpouzos Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island, USA Department of Dermatology, Medical School of Jundiaí, São Paulo, BrazilSearch for more papers by this authorDedee F. Murrell, Dedee F. Murrell Department of Dermatology, St George Hospital, Faculty of Medicine, University of New South Wales, Sydney, AustraliaSearch for more papers by this authorLidia Rudnicka, Lidia Rudnicka orcid.org/0000-0002-8308-1023 Department of Dermatology, Medical University of Warsaw, Warsaw, PolandSearch for more papers by this authorMohammad Jafferany, Mohammad Jafferany orcid.org/0000-0001-6358-9068 College of Medicine, Central Michigan University, Saginaw, MI, USASearch for more papers by this authorAlexander A. Navarini, Corresponding Author Alexander A. Navarini [email protected] Department of Dermatology and Allergy, University Hospital Basel, Basel, Switzerland Correspondence Alexander A. Navarini, Department of Dermatology and Allergy, University Hospital of Basel, Basel, Switzerland. Email: [email protected]Search for more papers by this author Mohamad Goldust, Mohamad Goldust orcid.org/0000-0002-9615-1246 Department of Dermatology and Allergy, University Hospital Basel, Basel, SwitzerlandSearch for more papers by this authorSwathi Shivakumar, Swathi Shivakumar orcid.org/0000-0002-4497-7687 Consultant Dermatologist, Cosmetiq Clinic, Thiruvananthapuram, Kerala, IndiaSearch for more papers by this authorGeorge Kroumpouzos, George Kroumpouzos Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island, USA Department of Dermatology, Medical School of Jundiaí, São Paulo, BrazilSearch for more papers by this authorDedee F. Murrell, Dedee F. Murrell Department of Dermatology, St George Hospital, Faculty of Medicine, University of New South Wales, Sydney, AustraliaSearch for more papers by this authorLidia Rudnicka, Lidia Rudnicka orcid.org/0000-0002-8308-1023 Department of Dermatology, Medical University of Warsaw, Warsaw, PolandSearch for more papers by this authorMohammad Jafferany, Mohammad Jafferany orcid.org/0000-0001-6358-9068 College of Medicine, Central Michigan University, Saginaw, MI, USASearch for more papers by this authorAlexander A. Navarini, Corresponding Author Alexander A. Navarini [email protected] Department of Dermatology and Allergy, University Hospital Basel, Basel, Switzerland Correspondence Alexander A. Navarini, Department of Dermatology and Allergy, University Hospital of Basel, Basel, Switzerland. Email: [email protected]Search for more papers by this author First published: 07 June 2020 https://doi.org/10.1111/dth.13774Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article.Citing Literature Volume33, Issue4July/August 2020e13774 RelatedInformation
This paper provides an overview of artificial-intelligence (AI), as applied to dermatology. We focus our discussion on methodology, AI applications for various skin diseases, limitations, and future opportunities. We review how the current image-based models are being implemented in dermatology across disease subsets, and highlight the challenges facing widespread adoption. Additionally, we discuss how the future of AI in dermatology might evolve and the emerging paradigm of large language, and multi-modal models to emphasize the importance of developing responsible, fair, and equitable models in dermatology.
Dermatologic TherapyVolume 33, Issue 4 e13343 Letter Learning from history: Coronavirus outbreaks in the past Pooja Arora, Pooja Arora orcid.org/0000-0002-0718-6990 Department of Dermatology, PGIMER and Dr Ram Manohar Lohia Hospital, New Delhi, IndiaSearch for more papers by this authorMohammad Jafferany, Mohammad Jafferany orcid.org/0000-0001-6358-9068 College of Medicine, Central Michigan University, Saginaw, Michigan, USASearch for more papers by this authorTorello Lotti, Torello Lotti orcid.org/0000-0003-0840-1936 Department of Dermatology, University of Studies Guglielmo Marconi, Rome, ItalySearch for more papers by this authorRoxanna Sadoughifar, Roxanna Sadoughifar Department of Dermatology, University of Rome G. Marconi, Rome, Italy Bidarskincenter, Tehran, IranSearch for more papers by this authorMohamad Goldust, Corresponding Author Mohamad Goldust [email protected] [email protected] orcid.org/0000-0002-9615-1246 Department of Dermatology, University of Rome G. Marconi, Rome, Italy Department of Dermatology, University Medical Center Mainz, Mainz, Germany Department of Dermatology, University Hospital Basel, Basel, Switzerland Correspondence Mohamad Goldust, Department of Dermatology, University Medical Center Mainz, Mainz, Germany. Email: [email protected]Search for more papers by this author Pooja Arora, Pooja Arora orcid.org/0000-0002-0718-6990 Department of Dermatology, PGIMER and Dr Ram Manohar Lohia Hospital, New Delhi, IndiaSearch for more papers by this authorMohammad Jafferany, Mohammad Jafferany orcid.org/0000-0001-6358-9068 College of Medicine, Central Michigan University, Saginaw, Michigan, USASearch for more papers by this authorTorello Lotti, Torello Lotti orcid.org/0000-0003-0840-1936 Department of Dermatology, University of Studies Guglielmo Marconi, Rome, ItalySearch for more papers by this authorRoxanna Sadoughifar, Roxanna Sadoughifar Department of Dermatology, University of Rome G. Marconi, Rome, Italy Bidarskincenter, Tehran, IranSearch for more papers by this authorMohamad Goldust, Corresponding Author Mohamad Goldust [email protected] [email protected] orcid.org/0000-0002-9615-1246 Department of Dermatology, University of Rome G. Marconi, Rome, Italy Department of Dermatology, University Medical Center Mainz, Mainz, Germany Department of Dermatology, University Hospital Basel, Basel, Switzerland Correspondence Mohamad Goldust, Department of Dermatology, University Medical Center Mainz, Mainz, Germany. Email: [email protected]Search for more papers by this author First published: 28 March 2020 https://doi.org/10.1111/dth.13343Citations: 11Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article.Citing Literature Volume33, Issue4July/August 2020e13343 This article also appears in:Dermatologic Therapy COVID-19 Articles RelatedInformation
Dermatologic TherapyVolume 33, Issue 4 e13339 Letter COVID-19 in the pediatric population Ayman Abdelmaksoud, Ayman Abdelmaksoud orcid.org/0000-0003-4848-959X Mansoura Dermatology, Venerology and Leprology Hospital, Mansoura, EgyptSearch for more papers by this authorGeorge Kroumpouzos, George Kroumpouzos Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island Department of Dermatology, Medical School of Jundiaí, São Paulo, BrazilSearch for more papers by this authorMohammad Jafferany, Mohammad Jafferany orcid.org/0000-0001-6358-9068 College of Medicine, Central Michigan University, Saginaw, Michigan, USASearch for more papers by this authorTorello Lotti, Torello Lotti orcid.org/0000-0003-0840-1936 University of Studies Guglielmo Marconi, Rome, ItalySearch for more papers by this authorRoxanna Sadoughifar, Roxanna Sadoughifar Bidarskincenter, Tehran, Iran University of Rome G. Marconi, Rome, ItalySearch for more papers by this authorMohamad Goldust, Corresponding Author Mohamad Goldust [email protected] orcid.org/0000-0002-9615-1246 Department of Dermatology, University Medical Center Mainz, Mainz, Germany Department of Dermatology, University Hospital Basel, Basel, Switzerland Correspondence Mohamad Goldust, Department of Dermatology, University Medical Center Mainz, Mainz,Germany. Email: [email protected]Search for more papers by this author Ayman Abdelmaksoud, Ayman Abdelmaksoud orcid.org/0000-0003-4848-959X Mansoura Dermatology, Venerology and Leprology Hospital, Mansoura, EgyptSearch for more papers by this authorGeorge Kroumpouzos, George Kroumpouzos Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island Department of Dermatology, Medical School of Jundiaí, São Paulo, BrazilSearch for more papers by this authorMohammad Jafferany, Mohammad Jafferany orcid.org/0000-0001-6358-9068 College of Medicine, Central Michigan University, Saginaw, Michigan, USASearch for more papers by this authorTorello Lotti, Torello Lotti orcid.org/0000-0003-0840-1936 University of Studies Guglielmo Marconi, Rome, ItalySearch for more papers by this authorRoxanna Sadoughifar, Roxanna Sadoughifar Bidarskincenter, Tehran, Iran University of Rome G. Marconi, Rome, ItalySearch for more papers by this authorMohamad Goldust, Corresponding Author Mohamad Goldust [email protected] orcid.org/0000-0002-9615-1246 Department of Dermatology, University Medical Center Mainz, Mainz, Germany Department of Dermatology, University Hospital Basel, Basel, Switzerland Correspondence Mohamad Goldust, Department of Dermatology, University Medical Center Mainz, Mainz,Germany. Email: [email protected]Search for more papers by this author First published: 27 March 2020 https://doi.org/10.1111/dth.13339Citations: 8Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article.Citing Literature Volume33, Issue4July/August 2020e13339 This article also appears in:Dermatologic Therapy COVID-19 Articles RelatedInformation
Astronomers have found the first confirmed atmosphere around a rocky planet in another star’s habitable zone。 The planet, LHS 1140 b, revealed its atmosphere through helium slowly leaking into space。 Located 48 light-years away, the world may have preserved its atmosphere for billions of years, making it a promising target in the search for potenti
A team of mathematicians used whimsical "silly sprinklers" to solve a physics mystery that has puzzled scientists for decades。 Their experiments showed that the rotation of both normal and reverse sprinklers is driven by the momentum of flowing water, not by the outside water flow or other long-standing theories。 The results finally provide a clear
Young Jupiter’s powerful magnetic field may have created a safe zone where several large moons could survive。 Saturn lacked this protection, possibly explaining why Titan stands almost alone among its largest moons
eBay sent bloody pig mask and other macabre deliveries to journalists' home
NASA’s Swift Observatory observed a supermassive black hole ripping apart a star more than 30,000 light-years from the center of a distant galaxy。 The extraordinary flare briefly outshone its entire host galaxy in ultraviolet light and revealed a black hole about a million times the Sun’s mass
Scientists have created twisted laser beams that interact differently with right-handed and left-handed molecules, revealing their identity through the fragments they produce。 The approach could provide a faster, simpler, and more sensitive way to analyze important molecules used in chemistry and pharmaceuticals
Conflicts of interest exist in dermatology when professional judgement concerning a primary interest, such as research validity, may be influenced by a secondary interest, such as financial gain from a for-profit organization. Conflict of interest is a condition and not a behaviour, although there is clear evidence that gifts influence behaviour. Little has been written about conflicts of interest in dermatology. This series of papers raises awareness of the subject by exploring it in greater depth from the perspective of a dermatology researcher, an industry researcher, a dermatology journal editor, a health services researcher and a patient representative. Collectively, they illustrate the many ways in which conflicts can pervade the world of dermatology publications and patient support group activities.
"I'm beginning to suspect we are not in Jumanji
A new review highlights exciting progress in atomically thin quantum materials where light and magnetism work together in ways never before possible。 In these materials, light-generated excitons can interact directly with magnetic behavior, creating opportunities to control magnetic states using light alone。 Scientists believe this could pave the w
"We're feeling pretty good about that," Boeing CEO Kelly Ortberg said
JWST has captured unusually detailed images of gas feeding the supermassive black hole at the center of NGC 4696。 A vast filament appears to funnel material into an 800-light-year-wide spinning disk, where gas races around at up to 600 kilometers per second。 The findings suggest black holes may recycle their own fuel by heating gas with jets and la
Scientists have created a programmable optical chip that can slow light on demand, giving engineers far greater control over how optical signals propagate through a circuit。 The technology could provide the delays, synchronization, and buffering functions needed to make light-based computing more practical。 A single chip could eventually perform se
Government ban on foreign-made robots may hinder instead of help US robotics
Scientists are testing two promising ways to destroy PFAS, the stubborn “forever chemicals” that can accumulate in water and resist normal treatment。 One method uses collapsing vapor bubbles to generate extreme heat and reactive molecules, while the other uses cold plasma and rising gas bubbles to pull PFAS to the surface and break them apart