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Large language models (LLMs) excel in various NLP tasks and modern medicine, but their evaluation in traditional Chinese medicine (TCM) is underexplored. To address this, we introduce TCM3CEval, a benchmark assessing LLMs in TCM across three dimensions: core knowledge mastery, classical text understanding, and clinical decision-making. We evaluate diverse models, including international (e.g., GPT-4o), Chinese (e.g., InternLM), and medical-specific (e.g., PLUSE). Results show a performance hierarchy: all models have limitations in specialized subdomains like Meridian & Acupoint theory and Various TCM Schools, revealing gaps between current capabilities and clinical needs. Models with Chinese linguistic and cultural priors perform better in classical text interpretation and clinical reasoning. TCM-3CEval sets a standard for AI evaluation in TCM, offering insights for optimizing LLMs in culturally grounded medical domains. The benchmark is available on Medbench's TCM track, aiming to assess LLMs' TCM capabilities in basic knowledge, classic texts, and clinical decision-making through multidimensional questions and real cases.

Background: Retrieval augmented generation (RAG) technology can empower large language models (LLMs) to generate more accurate, professional, and timely responses without fine tuning. However, due to the complex reasoning processes and substantial individual differences involved in traditional Chinese medicine (TCM) clinical diagnosis and treatment, traditional RAG methods often exhibit poor performance in this domain. Objective: To address the limitations of conventional RAG approaches in TCM applications, this study aims to develop an improved RAG framework tailored to the characteristics of TCM reasoning. Methods: We developed TCM-DiffRAG, an innovative RAG framework that integrates knowledge graphs (KG) with chains of thought (CoT). TCM-DiffRAG was evaluated on three distinctive TCM test datasets. Results: The experimental results demonstrated that TCM-DiffRAG achieved significant performance improvements over native LLMs. For example, the qwen-plus model achieved scores of 0.927, 0.361, and 0.038, which were significantly enhanced to 0.952, 0.788, and 0.356 with TCM-DiffRAG. The improvements were even more pronounced for non-Chinese LLMs. Additionally, TCM-DiffRAG outperformed

Traditional Chinese Medicine (TCM), as an effective alternative medicine, has been receiving increasing attention. In recent years, the rapid development of large language models (LLMs) tailored for TCM has highlighted the urgent need for an objective and comprehensive evaluation framework to assess their performance on real-world tasks. However, existing evaluation datasets are limited in scope and primarily text-based, lacking a unified and standardized multimodal question-answering (QA) benchmark. To address this issue, we introduce TCM-Ladder, the first comprehensive multimodal QA dataset specifically designed for evaluating large TCM language models. The dataset covers multiple core disciplines of TCM, including fundamental theory, diagnostics, herbal formulas, internal medicine, surgery, pharmacognosy, and pediatrics. In addition to textual content, TCM-Ladder incorporates various modalities such as images and videos. The dataset was constructed using a combination of automated and manual filtering processes and comprises over 52,000 questions. These questions include single-choice, multiple-choice, fill-in-the-blank, diagnostic dialogue, and visual comprehension tasks. We tr

Large language models (LLMs) primarily trained on English texts, often face biases and inaccuracies in Chinese contexts. Their limitations are pronounced in fields like Traditional Chinese Medicine (TCM), where cultural and clinical subtleties are vital, further hindered by a lack of domain-specific data, such as rheumatoid arthritis (RA). To address these issues, this paper introduces Hengqin-RA-v1, the first large language model specifically tailored for TCM with a focus on diagnosing and treating RA. We also present HQ-GCM-RA-C1, a comprehensive RA-specific dataset curated from ancient Chinese medical literature, classical texts, and modern clinical studies. This dataset empowers Hengqin-RA-v1 to deliver accurate and culturally informed responses, effectively bridging the gaps left by general-purpose models. Extensive experiments demonstrate that Hengqin-RA-v1 outperforms state-of-the-art models, even surpassing the diagnostic accuracy of TCM practitioners in certain cases.

Large Language Models (LLMs) have demonstrated remarkable capabilities in modern medicine, yet their application in Traditional Chinese Medicine (TCM) remains severely limited by the absence of standardized benchmarks and the scarcity of high-quality training data. To address these challenges, we introduce TCM-Eval, the first dynamic and extensible benchmark for TCM, meticulously curated from national medical licensing examinations and validated by TCM experts. Furthermore, we construct a large-scale training corpus and propose Self-Iterative Chain-of-Thought Enhancement (SI-CoTE) to autonomously enrich question-answer pairs with validated reasoning chains through rejection sampling, establishing a virtuous cycle of data and model co-evolution. Using this enriched training data, we develop ZhiMingTang (ZMT), a state-of-the-art LLM specifically designed for TCM, which significantly exceeds the passing threshold for human practitioners. To encourage future research and development, we release a public leaderboard, fostering community engagement and continuous improvement.

Despite the success of large language models (LLMs) in various domains, their potential in Traditional Chinese Medicine (TCM) remains largely underexplored due to two critical barriers: (1) the scarcity of high-quality TCM data and (2) the inherently multimodal nature of TCM diagnostics, which involve looking, listening, smelling, and pulse-taking. These sensory-rich modalities are beyond the scope of conventional LLMs. To address these challenges, we present ShizhenGPT, the first multimodal LLM tailored for TCM. To overcome data scarcity, we curate the largest TCM dataset to date, comprising 100GB+ of text and 200GB+ of multimodal data, including 1.2M images, 200 hours of audio, and physiological signals. ShizhenGPT is pretrained and instruction-tuned to achieve deep TCM knowledge and multimodal reasoning. For evaluation, we collect recent national TCM qualification exams and build a visual benchmark for Medicinal Recognition and Visual Diagnosis. Experiments demonstrate that ShizhenGPT outperforms comparable-scale LLMs and competes with larger proprietary models. Moreover, it leads in TCM visual understanding among existing multimodal LLMs and demonstrates unified perception acro

Traditional Chinese Medicine (TCM) involves complex compatibility mechanisms characterized by multi-component and multi-target interactions, which are challenging to quantify. To address this challenge, we applied graph artificial intelligence to develop a TCM multi-dimensional knowledge graph that bridges traditional TCM theory and modern biomedical science (https://zenodo.org/records/13763953 ). Using feature engineering and embedding, we processed key TCM terminology and Chinese herbal pieces (CHP), introducing medicinal properties as virtual nodes and employing graph neural networks with attention mechanisms to model and analyze 6,080 Chinese herbal formulas (CHF). Our method quantitatively assessed the roles of CHP within CHF and was validated using 215 CHF designed for COVID-19 management. With interpretable models, open-source data, and code (https://github.com/ZENGJingqi/GraphAI-for-TCM ), this study provides robust tools for advancing TCM theory and drug discovery.

The rise of autonomous driving technology has led to concerns about inactivity-induced fatigue. This paper explores Traditional Chinese Medicine (TCM) scents for mitigating. Two human-involved studies have been conducted in a high-fidelity driving simulator. Study 1 maps six prevalent TCM scents onto the arousal/valence circumplex to select proper candidates, i.e., argy wormwood (with the highest arousal) and tangerine peel (with the highest valence). Study 2 tests both scents in an auto-driving course. Statistics show both scents can improve driver alertness and reaction-time, but should be used in different ways: argy wormwood is suitable for short-term use due to its higher intensity but poor acceptance, while tangerine peel is ideal for long-term use due to its higher likeness. These findings provide insights for in-car fatigue mitigation to enhance driver safety and well-being. However, issues such as scent longevity as for aromatherapy and automatic fatigue prediction remain unresolved.

Large Language Models (LLMs) has made significant progress in a number of professional fields, including medicine, law, and finance. However, in traditional Chinese medicine (TCM), there are challenges such as the essential differences between theory and modern medicine, the lack of specialized corpus resources, and the fact that relying only on supervised fine-tuning may lead to overconfident predictions. To address these challenges, we propose a two-stage training approach that combines continuous pre-training and supervised fine-tuning. A notable contribution of our study is the processing of a 2GB corpus dedicated to TCM, constructing pre-training and instruction fine-tuning datasets for TCM, respectively. In addition, we have developed Qibo-Benchmark, a tool that evaluates the performance of LLM in the TCM on multiple dimensions, including subjective, objective, and three TCM NLP tasks. The medical LLM trained with our pipeline, named $\textbf{Qibo}$, exhibits significant performance boosts. Compared to the baselines, the average subjective win rate is 63%, the average objective accuracy improved by 23% to 58%, and the Rouge-L scores for the three TCM NLP tasks are 0.72, 0.61,

No previous work has studied the performance of Large Language Models (LLMs) in the context of Traditional Chinese Medicine (TCM), an essential and distinct branch of medical knowledge with a rich history. To bridge this gap, we present a TCM question dataset named TCM-QA, which comprises three question types: single choice, multiple choice, and true or false, to examine the LLM's capacity for knowledge recall and comprehensive reasoning within the TCM domain. In our study, we evaluate two settings of the LLM, zero-shot and few-shot settings, while concurrently discussing the differences between English and Chinese prompts. Our results indicate that ChatGPT performs best in true or false questions, achieving the highest precision of 0.688 while scoring the lowest precision is 0.241 in multiple-choice questions. Furthermore, we observed that Chinese prompts outperformed English prompts in our evaluations. Additionally, we assess the quality of explanations generated by ChatGPT and their potential contribution to TCM knowledge comprehension. This paper offers valuable insights into the applicability of LLMs in specialized domains and paves the way for future research in leveraging th

This paper explores the application of prompt engineering to enhance the performance of large language models (LLMs) in the domain of Traditional Chinese Medicine (TCM). We propose TCM-Prompt, a framework that integrates various pre-trained language models (PLMs), templates, tokenization, and verbalization methods, allowing researchers to easily construct and fine-tune models for specific TCM-related tasks. We conducted experiments on disease classification, syndrome identification, herbal medicine recommendation, and general NLP tasks, demonstrating the effectiveness and superiority of our approach compared to baseline methods. Our findings suggest that prompt engineering is a promising technique for improving the performance of LLMs in specialized domains like TCM, with potential applications in digitalization, modernization, and personalized medicine.

Pre-training and fine-tuning have emerged as a promising paradigm across various natural language processing (NLP) tasks. The effectiveness of pretrained large language models (LLM) has witnessed further enhancement, holding potential for applications in the field of medicine, particularly in the context of Traditional Chinese Medicine (TCM). However, the application of these general models to specific domains often yields suboptimal results, primarily due to challenges like lack of domain knowledge, unique objectives, and computational efficiency. Furthermore, their effectiveness in specialized domains, such as Traditional Chinese Medicine, requires comprehensive evaluation. To address the above issues, we propose a novel domain specific TCMDA (TCM Domain Adaptation) approach, efficient pre-training with domain-specific corpus. Specifically, we first construct a large TCM-specific corpus, TCM-Corpus-1B, by identifying domain keywords and retreving from general corpus. Then, our TCMDA leverages the LoRA which freezes the pretrained model's weights and uses rank decomposition matrices to efficiently train specific dense layers for pre-training and fine-tuning, efficiently aligning t

Traditional Chinese medicine (TCM) prescription is the most critical form of TCM treatment, and uncovering the complex nonlinear relationship between symptoms and TCM is of great significance for clinical practice and assisting physicians in diagnosis and treatment. Although there have been some studies on TCM prescription generation, these studies consider a single factor and directly model the symptom-prescription generation problem mainly based on symptom descriptions, lacking guidance from TCM knowledge. To this end, we propose a RoBERTa and Knowledge Enhancement model for Prescription Generation of Traditional Chinese Medicine (RoKEPG). RoKEPG is firstly pre-trained by our constructed TCM corpus, followed by fine-tuning the pre-trained model, and the model is guided to generate TCM prescriptions by introducing four classes of knowledge of TCM through the attention mask matrix. Experimental results on the publicly available TCM prescription dataset show that RoKEPG improves the F1 metric by about 2% over the baseline model with the best results.

The surge of large language models (LLMs) has driven significant progress in medical applications, including traditional Chinese medicine (TCM). However, current medical LLMs struggle with TCM diagnosis and syndrome differentiation due to substantial differences between TCM and modern medical theory, and the scarcity of specialized, high-quality corpora. To this end, in this paper we propose BianCang, a TCM-specific LLM, using a two-stage training process that first injects domain-specific knowledge and then aligns it through targeted stimulation to enhance diagnostic and differentiation capabilities. Specifically, we constructed pre-training corpora, instruction-aligned datasets based on real hospital records, and the ChP-TCM dataset derived from the Pharmacopoeia of the People's Republic of China. We compiled extensive TCM and medical corpora for continual pre-training and supervised fine-tuning, building a comprehensive dataset to refine the model's understanding of TCM. Evaluations across 11 test sets involving 31 models and 4 tasks demonstrate the effectiveness of BianCang, offering valuable insights for future research. Code, datasets, and models are available on https://gith