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A person’s sleeping brain may reveal warning signs of dementia long before memory problems begin。 Researchers used machine learning to analyze EEG recordings from about 7,000 adults and found that an older-than-expected “brain age” was tied to a sharply higher dementia risk。 Every additional 10 years of brain aging raised that risk by nearly 40%
Stress may literally scramble the brain’s internal GPS。 Researchers found that cortisol, a hormone released during stress, made people significantly worse at navigating a virtual environment and disrupted the precise activity of grid cells, specialized brain cells that help us understand where we are in space。 When landmarks were missing, this navi
Weight loss is not simply a test of willpower。 The human brain evolved to protect body fat during times of scarcity, and it can treat a previously higher weight as the new normal, triggering stronger hunger, cravings, and lower energy use after weight loss。 This biological “memory” helps explain why many people regain weight after dieting and why m
Beginning around age 50, the brain’s memory center appears to lose many of its longtime immune cells and replace them with more inflammatory ones。 This surprising shift may help explain how normal aging sets the stage for Alzheimer’s disease and dementia
An exceptionally preserved snake fossil from Brazil reveals that early snakes were far more diverse than scientists once thought。 Detailed brain reconstructions show that Tametara mirim was adapted for burrowing, while another ancient snake was suited to life above ground。 Other fossils point to marine lifestyles as well
Scientists have identified a molecular switch that may help explain why aging makes the brain more vulnerable to diseases such as ALS and Huntington’s。 In worms, the protein EPS8 builds up with age and triggers signaling that encourages toxic proteins to clump together, damaging neurons and shortening lifespan。 Reducing EPS8 activity prevented thes
A group of brain cells called orexin neurons appears to help us keep working when reaching a reward becomes increasingly difficult。 Blocking their activity weakened motivation in rats, pointing to a possible new target for understanding why people sometimes struggle to sustain goal-directed behavior
Blocking the glycine transporter SLC6A20 restored important brain signaling and improved social, communication, and repetitive behaviors in autism-related mouse models。 The treatment also worked in human brain organoids and showed lasting effects in adult mice, suggesting the brain may remain more treatable later in life than previously thought
A long-term brain study found that common risks such as smoking, high blood pressure, heart disease, and high blood lipids were strongly linked to damage associated with vascular dementia。 The findings suggest that healthier lifestyle choices could help delay dementia by reducing several harmful brain changes at once
A new wearable patch may help people reach REM sleep faster and remain there longer without medication or surgery。 In a study of 28 participants, the device shortened the time to REM by 43 minutes and extended it by about 16 minutes。 Researchers also observed signs of improved stress regulation and changes in brain circuits tied to emotion
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