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The presence of an expanded polyglutamine produces a toxic gain of function in huntingtin. Protein aggregation resulting from this gain of function is likely to be the cause of neuronal death. Two main mechanisms of aggregation have been proposed: hydrogen bonding by polar-zipper formation and covalent bonding by transglutaminase-catalyzed cross-linking. In cell culture models of Huntington's disease, aggregates are mostly stabilized by hydrogen bonds, but covalent bonds are also likely to occur. Nothing is known about the nature of the bonds that stabilize the aggregates in the brain of patients with Huntington's disease. It seems that the nature of the bond stabilizing the aggregates is one of the most important questions, as the answer would condition the therapeutic approach to Huntington's disease.
The COVID-19 pandemic has given rise to numerous articles from different scientific fields (epidemiology, virology, immunology, airflow physics...) without any effort to link these different insights. In this review, we aim to establish relationships between epidemiological data and the characteristics of the virus strain responsible for the epidemic wave concerned. We have carried out this study on the Wuhan, Alpha, Delta and Omicron strains allowing us to illustrate the evolution of the relationships we have highlighted according to these different viral strains. We addressed the following questions: 1) How can the mean infectious dose (one quantum, by definition in epidemiology) be measured and expressed as an amount of viral RNA molecules (in genome units, GU) or as a number of replicative viral particles (in plaque-forming units, PFU)? 2) How many infectious quanta are exhaled by an infected person per unit of time? 3) How many infectious quanta are exhaled, on average, integrated over the whole contagious period? 4) How do these quantities relate to the epidemic reproduction rate R as measured in epidemiology, and to the viral load, as measured by molecular biological methods
Young Jupiter’s powerful magnetic field may have created a safe zone where several large moons could survive。 Saturn lacked this protection, possibly explaining why Titan stands almost alone among its largest moons
Scientists have created twisted laser beams that interact differently with right-handed and left-handed molecules, revealing their identity through the fragments they produce。 The approach could provide a faster, simpler, and more sensitive way to analyze important molecules used in chemistry and pharmaceuticals
Researchers have created self-destructing living plastic that uses engineered bacteria to completely break itself down when activated。 The material degrades in just six days without creating microplastics, offering a potential new solution for single-use plastic waste
MIT engineers have found a way to give chip-based lidar a wider, clearer view without relying on moving parts。 Their design uses differently shaped antennas that can sit close together without scrambling one another’s signals。 In tests, the system sharply reduced interference while steering a single precise beam across a broad field of view
Cosmic expansion allows distant galaxies to move away faster than light, while still letting us see ancient light they emitted when they were much closer。 Eventually, accelerating expansion will push nearly every galaxy beyond our Local Group out of sight, making the Universe appear almost empty
A new analysis suggests the Sun holds far more silver than earlier estimates indicated。 More advanced models of the solar atmosphere raised the calculated amount by 55 percent, bringing it into much closer agreement with ancient meteorites。 The technique may also help scientists track the cosmic origins of silver and other heavy elements
Ultrafast X-rays revealed how a molecule converts absorbed light into motion in just trillionths of a second。 Individual atoms recorded different stages of the process, opening a powerful new window into light-driven chemistry
Sony doesn't think the move will hurt it financially
Wavelength and intensity in the infrared are translated into colors in the visible
China’s Chang’e-6 samples have uncovered a surprising difference between the Moon’s two hemispheres。 Solar wind particles penetrated deeper into the far-side soil because Earth’s magnetosphere slows the particles that reach the near side。 Noble gases locked inside the lunar regolith preserved evidence of this uneven bombardment
Scientists are testing two promising ways to destroy PFAS, the stubborn “forever chemicals” that can accumulate in water and resist normal treatment。 One method uses collapsing vapor bubbles to generate extreme heat and reactive molecules, while the other uses cold plasma and rising gas bubbles to pull PFAS to the surface and break them apart
A team of mathematicians used whimsical "silly sprinklers" to solve a physics mystery that has puzzled scientists for decades。 Their experiments showed that the rotation of both normal and reverse sprinklers is driven by the momentum of flowing water, not by the outside water flow or other long-standing theories。 The results finally provide a clear
Researchers have created cosmic dust from scratch by recreating space-like conditions inside glass tubes。 The dust contains complex carbon-rich molecules built from elements essential to life and produces infrared signals similar to real material found in space。 By studying these laboratory samples, scientists can explore how organic chemistry unfo
A distant Sun-like star appears to have devoured one of its planets, leaving behind a surprising chemical fingerprint。 Researchers found an unusually high concentration of lithium, a strong sign that planetary material was mixed into the star。 Careful comparisons with dozens of similar stars confirmed the signal is highly unusual, and scientists th