搜索结果：Annals of Ibadan postgraduate medicine

The revolutionary progress in development of next-generation sequencing (NGS) technologies has made it possible to deliver accurate genomic information in a timely manner. Over the past several years, NGS has transformed biomedical and clinical research and found its application in the field of personalized medicine. Here we discuss the rise of personalized medicine and the history of NGS. We discuss current applications and uses of NGS in medicine, including infectious diseases, oncology, genomic medicine, and dermatology. We provide a brief discussion of selected studies where NGS was used to respond to wide variety of questions in biomedical research and clinical medicine. Finally, we discuss the challenges of implementing NGS into routine clinical use.

What does Artificial Intelligence (AI) have to contribute to health care? And what should we be looking out for if we are worried about its risks? In this paper we offer a survey, and initial evaluation, of hopes and fears about the applications of artificial intelligence in medicine. AI clearly has enormous potential as a research tool, in genomics and public health especially, as well as a diagnostic aid. It's also highly likely to impact on the organisational and business practices of healthcare systems in ways that are perhaps under-appreciated. Enthusiasts for AI have held out the prospect that it will free physicians up to spend more time attending to what really matters to them and their patients. We will argue that this claim depends upon implausible assumptions about the institutional and economic imperatives operating in contemporary healthcare settings. We will also highlight important concerns about privacy, surveillance, and bias in big data, as well as the risks of over trust in machines, the challenges of transparency, the deskilling of healthcare practitioners, the way AI reframes healthcare, and the implications of AI for the distribution of power in healthcare ins

Blended learning has become a dominant educational model in higher education in the UK and worldwide, particularly after the COVID-19 pandemic. This is further enriched with accompanying pedagogical changes, such as strengthened asynchronous learning, and the use of AI (from ChatGPT and all other similar tools that followed) and other technologies to aid learning. While these educational transformations have enabled flexibility in learning and resource access, they have also exposed new challenges on how students can construct successful learning in hybrid learning environments. In this paper, we investigate the interaction between different dimensions of student learning experiences (ranging from perceived acceptance of teaching methods and staff support/feedback to learning pressure and student motivation) and academic achievement within the context of postgraduate blended learning in UK universities. To achieve this, we employed a combination of several data analytics techniques including visualization, statistical tests, regression analysis, and latent profile analysis. Our empirical results (based on a survey of 255 postgraduate students and holistically interpreted via the Co

Recent studies indicate that Generative Pre-trained Transformer 4 with Vision (GPT-4V) outperforms human physicians in medical challenge tasks. However, these evaluations primarily focused on the accuracy of multi-choice questions alone. Our study extends the current scope by conducting a comprehensive analysis of GPT-4V's rationales of image comprehension, recall of medical knowledge, and step-by-step multimodal reasoning when solving New England Journal of Medicine (NEJM) Image Challenges - an imaging quiz designed to test the knowledge and diagnostic capabilities of medical professionals. Evaluation results confirmed that GPT-4V performs comparatively to human physicians regarding multi-choice accuracy (81.6% vs. 77.8%). GPT-4V also performs well in cases where physicians incorrectly answer, with over 78% accuracy. However, we discovered that GPT-4V frequently presents flawed rationales in cases where it makes the correct final choices (35.5%), most prominent in image comprehension (27.2%). Regardless of GPT-4V's high accuracy in multi-choice questions, our findings emphasize the necessity for further in-depth evaluations of its rationales before integrating such multimodal AI m

Due to the nature of most postgraduate theses in control engineering and their similarities to industrial and software engineering projects, invoking novel project control techniques could be effective. In recent decades, agile techniques have attracted popularity thanks to their attributes in delivering successful projects. Hence exploiting those methods in education and thesis supervision of engineering topics can facilitate the process. On the other hand, because of the limitations imposed by the CoVid19 pandemic, the integration of well-established online tools in collaborative education is noteworthy. This paper proposes an application of the agile project management method for the supervision of postgraduate students' theses in the general field of engineering. The study extends a Scrum technique combined with approved systems engineering and team working tools such as Jira Software, Microsoft Teams, and Git version control (Github website). A custom designed V-model to nail an outstanding thesis is presented. The overall blended method is beneficial to provide feedback and self-assessment aid for the students and the supervisors. Employing this technique has shown promising

There is increasing pressure generally for lecturers to adapt their supervision practices of postgraduate students to better prepare postgraduate students for careers outside of academia. In this paper we examine what such pressure may mean for the supervision and preparation of theoretical physicists specifically, theoretical physics being a sub-discipline of physics usually perceived as a highly specialised niche area of scientific practice. In this exploratory study we apply the concepts of the Specialisation Dimension of Legitimation Code Theory to analyse and reveal the dominant concepts and codes, as well as the code shifts that may occur during postgraduate studies, based on an autoethnographic account of theoretical physicist identity development. The findings demonstrate an underpinning value for both knowledge and knower attributes in the journey to becoming a legitimate theoretical physicist, and the critical role played by postgraduate supervisors in facilitating the process of theoretical physicist identity development. Also highlighted are possible implications for supervisors faced with students intending to take up employment outside of academia.

Medicine, including fields in healthcare and life sciences, has seen a flurry of quantum-related activities and experiments in the last few years (although biology and quantum theory have arguably been entangled ever since Schrödinger's cat). The initial focus was on biochemical and computational biology problems; recently, however, clinical and medical quantum solutions have drawn increasing interest. The rapid emergence of quantum computing in health and medicine necessitates a mapping of the landscape. In this review, clinical and medical proof-of-concept quantum computing applications are outlined and put into perspective. These consist of over 40 experimental and theoretical studies. The use case areas span genomics, clinical research and discovery, diagnostics, and treatments and interventions. Quantum machine learning (QML) in particular has rapidly evolved and shown to be competitive with classical benchmarks in recent medical research. Near-term QML algorithms have been trained with diverse clinical and real-world data sets. This includes studies in generating new molecular entities as drug candidates, diagnosing based on medical image classification, predicting patient pe

The last few years have seen rapid progress in transitioning quantum computing from lab to industry. In healthcare and life sciences, more than 40 proof-of-concept experiments and studies have been conducted; an increasing number of these are even run on real quantum hardware. Major investments have been made with hundreds of millions of dollars already allocated towards quantum applications and hardware in medicine. In addition to pharmaceutical and life sciences uses, clinical and medical applications are now increasingly coming into the picture. This chapter focuses on three key use case areas associated with (precision) medicine, including genomics and clinical research, diagnostics, and treatments and interventions. Examples of organizations and the use cases they have been researching are given; ideas how the development of practical quantum computing applications can be further accelerated are described.

A historical record of a seismic tsunami is identified in the Irish annals for October 720 (all dates herein CE). It is contained in the earliest stratum of the annals, which survives in the form of a handful of iterated scribal copies of the foundational text of the tradition. This was compiled by the contemporary observation of noteworthy events for the years c. 563-740 at the monastery of Iona in the Scottish Hebrides. The 720 event is close outside the 2$σ$ radiocarbon terminus ante quem date ranges for tsunami deposits identified at Dury Voe (530-660) and Basta Voe (430-650) in the Shetland Isles, and is identified as a candidate progenitor. The possibility of the existence of associated tsunami deposits in Scotland or on the north coast of Ireland is highlighted.

Background: Harnessing advanced computing for scientific discovery and technological innovation demands scientists and engineers well-versed in both domain science and computational science and engineering (CSE). However, few universities provide access to both integrated domain science/CSE cross-training and Top-500 High-Performance Computing (HPC) facilities. National laboratories offer internship opportunities capable of developing these skills. Purpose: This student presents an evaluation of federally-funded postgraduate internship outcomes at a national laboratory. This study seeks to answer three questions: 1) What computational skills, research skills, and professional skills do students improve through internships at the selected national laboratory. 2) Do students gain knowledge in domain science topics through their internships. 3) Do students' career interests change after these internships? Design/Method: We developed a survey and collected responses from past participants of five federally-funded internship programs and compare participant ratings of their prior experience to their internship experience. Findings: Our results indicate that participants improve CSE skil

Phosphorus (P) is considered to be one of the key elements for life, making it an important element to look for in the abundance analysis of spectra of stellar systems. Yet, there exists only a handful of spectroscopic studies to estimate the P abundances and investigate its trend across a range of metallicities. We have observed full HK band spectra at a spectral resolving power of R=45,000 with IGRINS instrument. Abundances are determined using SME in combination with 1D MARCS stellar atmosphere models. The investigated sample of stars have reliable stellar parameters estimated using optical FIES spectra (GILD; Jönsson et al. in prep.). In order to determine the P abundances from the 16482.92 Angstrom P line, we take special care of the CO($ν=7-4$) blend. We determine the C, N, O abundances from atomic carbon and a range of non-blended molecular lines (CO, CN, OH) which are aplenty in the H band region of K giant stars, assuring an appropriate modelling of the blending CO($ν=7-4$) line. We present [P/Fe] vs [Fe/H] trend for 38 K giant stars in the metallicity range of -1.2 dex $<$ [Fe/H] $<$ 0.4 dex. We find that our trend matches well with the compiled literature sample of

Model Medicine is the science of understanding, diagnosing, treating, and preventing disorders in AI models, grounded in the principle that AI models -- like biological organisms -- have internal structures, dynamic processes, heritable traits, observable symptoms, classifiable conditions, and treatable states. This paper introduces Model Medicine as a research program, bridging the gap between current AI interpretability research (anatomical observation) and the systematic clinical practice that complex AI systems increasingly require. We present five contributions: (1) a discipline taxonomy organizing 15 subdisciplines across four divisions -- Basic Model Sciences, Clinical Model Sciences, Model Public Health, and Model Architectural Medicine; (2) the Four Shell Model (v3.3), a behavioral genetics framework empirically grounded in 720 agents and 24,923 decisions from the Agora-12 program, explaining how model behavior emerges from Core--Shell interaction; (3) Neural MRI (Model Resonance Imaging), a working open-source diagnostic tool mapping five medical neuroimaging modalities to AI interpretability techniques, validated through four clinical cases demonstrating imaging, compari

Eccentric planets may spend a significant portion of their orbits at large distances from their host stars, where low temperatures can cause atmospheric CO2 to condense out onto the surface, similar to the polar ice caps on Mars. The radiative effects on the climates of these planets throughout their orbits would depend on the wavelength-dependent albedo of surface CO2 ice that may accumulate at or near apoastron and vary according to the spectral energy distribution of the host star. To explore these possible effects, we incorporated a CO2 ice-albedo parameterization into a one-dimensional energy balance climate model. With the inclusion of this parameterization, our simulations demonstrated that F-dwarf planets require 29% more orbit-averaged flux to thaw out of global water ice cover compared with simulations that solely use a traditional pure water ice-albedo parameterization. When no eccentricity is assumed, and host stars are varied, F-dwarf planets with higher bond albedos relative to their M-dwarf planet counterparts require 30% more orbit-averaged flux to exit a water snowball state. Additionally, the intense heat experienced at periastron aids eccentric planets in exiting

Given the growing use of generative artificial intelligence as a tool for creating multilingual content and bypassing both machine and traditional translation methods, this study explores the ability of linguistically trained individuals to discern machine-generated output from human-written text (HT). After brief training sessions on the textual anomalies typically found in synthetic text (ST), twenty-three postgraduate translation students analysed excerpts of Italian prose and assigned likelihood scores to indicate whether they believed they were human-written or AI-generated (ChatGPT-4o). The results show that, on average, the students struggled to distinguish between HT and ST, with only two participants achieving notable accuracy. Closer analysis revealed that the students often identified the same textual anomalies in both HT and ST, although features such as low burstiness and self-contradiction were more frequently associated with ST. These findings suggest the need for improvements in the preparatory training. Moreover, the study raises questions about the necessity of editing synthetic text to make it sound more human-like and recommends further research to determine whe

3D data from high-resolution volumetric imaging is a central resource for diagnosis and treatment in modern medicine. While the fast development of AI enhances imaging and analysis, commonly used visualization methods lag far behind. Recent research used extended reality (XR) for perceiving 3D images with visual depth perception and touch but used restrictive haptic devices. While unrestricted touch benefits volumetric data examination, implementing natural haptic interaction with XR is challenging. The research question is whether a multisensory XR application with intuitive haptic interaction adds value and should be pursued. In a study, 24 experts for biomedical images in research and medicine explored 3D medical shapes with 3 applications: a multisensory virtual reality (VR) prototype using haptic gloves, a simple VR prototype using controllers, and a standard PC application. Results of standardized questionnaires showed no significant differences between all application types regarding usability and no significant difference between both VR applications regarding presence. Participants agreed to statements that VR visualizations provide better depth information, using the hand

Retrieval shapes how language models access and ground knowledge in retrieval-augmented generation (RAG). In historical research, the target is often not an arbitrary relevant passage, but the exact record for a specific regnal month, where temporal consistency matters as much as topical relevance. This is especially challenging for Classical Chinese annals, where time is expressed through terse, implicit, non-Gregorian reign phrases that must be interpreted from surrounding context, so semantically plausible evidence can still be temporally invalid. We introduce \textbf{ChunQiuTR}, a time-keyed retrieval benchmark built from the \textit{Spring and Autumn Annals} and its exegetical tradition. ChunQiuTR organizes records by month-level reign keys and includes chrono-near confounders that mirror realistic retrieval failures. We further propose \textbf{CTD} (Calendrical Temporal Dual-encoder), a time-aware dual-encoder that combines Fourier-based absolute calendrical context with relative offset biasing. Experiments show consistent gains over strong semantic dual-encoder baselines under time-keyed evaluation, supporting retrieval-time temporal consistency as a key prerequisite for fai

In many academic settings, medical students start their scientific work already during their studies. Like at our institution, they often work in interdisciplinary teams with more or less experienced (postgraduate) researchers of pharmaceutical sciences, natural sciences in general, or biostatistics. All of them should be taught good research practices as an integral part of their education, especially in terms of statistical analysis. This includes reproducibility as a central aspect of modern research. Acknowledging that even educators might be unfamiliar with necessary aspects of a perfectly reproducible workflow, I agreed to give a lecture series on reproducible research (RR) for medical students and postgraduate pharmacists involved in several areas of clinical research. Thus, I designed a piloting lecture series to highlight definitions of RR, reasons for RR, potential merits of RR, and ways to work accordingly. In trying to actually reproduce a published analysis, I encountered several practical obstacles. In this article, I focus on this working example to emphasize the manifold facets of RR, to provide possible explanations and solutions, and argue that harmonized curricul

In its broadest definition, systems biology is the application of a `systems' way of thinking about and doing cell biology. By implication, this also invites us to consider a systems approach in the context of medicine and the treatment of disease. In particular, the idea that systems biology can form the basis of a personalised, predictive medicine will require that much closer attention is paid to the analytic properties of the feedback loops which will be set up by a personalised approach to healthcare. To emphasize the role that feedback theory will play in understanding personalised medicine, we use the term feedback medicine to describe the issues outlined.In these notes we consider feedback and control systems concepts applied to two important themes in medical systems biology - personalised medicine and combinatorial intervention. In particular, we formulate a feedback control interpretation for the administration of medicine, and relate them to various forms of medical treatment.

Medical image analysis plays a key role in precision medicine as it allows the clinicians to identify anatomical abnormalities and it is routinely used in clinical assessment. Data curation and pre-processing of medical images are critical steps in the quantitative medical image analysis that can have a significant impact on the resulting model performance. In this paper, we introduce a precision-medicine-toolbox that allows researchers to perform data curation, image pre-processing and handcrafted radiomics extraction (via Pyradiomics) and feature exploration tasks with Python. With this open-source solution, we aim to address the data preparation and exploration problem, bridge the gap between the currently existing packages, and improve the reproducibility of quantitative medical imaging research.