[Association of urinary personal care products levels with diabetes in adults aged 18 years and above in China].

内容摘要

Objective: To investigate the association between urinary personal care products (PCPs) level and the risk of diabetes among adults aged 18-79 years. Methods: Data was derived from the China National Human Biomonitoring survey conducted in 2017-2018, with a final sample size of 911 adults. Information on general demographic characteristics, behavioral habits, and dietary frequency was collected through questionnaire surveys and physical examinations. Fasting venous blood and midstream random urine samples were collected to measure fasting blood glucose and urinary personal care product levels. Multivariable logistic regression models were used to examine the associations between urinary PCP levels and diabetes prevalence. Subgroup analyses were further conducted according to age, sex, residence, and history of hair dyeing or perming. Results: A total of 911 participants were included in this study, including 458 females (50.3%), 319 residents aged 19-39 years (35.0%), and 456 rural residents (50.1%). The concentrations of the three parabens were 23.30 (20.73, 26.19), 2.00 (1.74, 2.30), and 2.74 (2.34, 3.22) μg/g creatinine, respectively. Multivariable logistic regression analysis showed that, after adjusting for potential confounding factors, urinary ethyl paraben (EtP) levels were positively associated with diabetes prevalence (OR=1.17, 95%CI: 1.02-1.34, P=0.025). Subgroup analyses further showed that the positive association between urinary EtP levels and diabetes prevalence was stronger among females (OR=1.25, 95%CI: 1.02-1.54, P=0.029) and individuals with a history of hair dyeing or perming (OR=1.29, 95%CI: 1.05-1.59, P=0.016). Conclusion: Urinary ethyl paraben exposure was positively associated with an increased risk of diabetes among Chinese adults, with women and individuals with a history of hair dyeing or perming potentially representing susceptible subpopulations warranting further attention. 目的： 探讨我国18~79岁成年人尿液个人护理品水平与糖尿病患病风险的关联。 方法： 研究对象来自2017—2018年国家人体生物监测项目，纳入年龄≥18岁的人群。通过问卷调查和体格检查收集研究对象的一般人口学特征、行为习惯和膳食频率等信息；采集调查对象空腹静脉血及中段随机尿并检测空腹血糖及尿液个人护理品水平。采用多因素logistic回归模型分析尿液个人护理品水平与糖尿病患病的关联，并根据年龄、性别、居住地和染发烫发经历进行亚组分析。 结果： 共纳入911名研究对象，其中女性458名（50.3%），19~39岁居民319名（35.0%），农村居民456名（50.1%）。3种对羟基苯甲酸酯的浓度分别为23.30（20.73，26.19）、2.00（1.74，2.30）和2.74（2.34，3.22）μg/g·肌酐。多因素logistic回归分析显示，调整相关混杂因素后，乙基对羟基苯甲酸酯水平与糖尿病患病风险之间呈正向关联（OR=1.17，95%CI：1.02~1.34，P=0.025）。根据性别和染发烫发经历进行亚组分显示，女性（OR=1.25，95%CI：1.02~1.54，P=0.029）、染发烫发人群（OR=1.29，95%CI：1.05~1.59，P=0.016）中乙基对羟基苯甲酸酯暴露与糖尿病患病风险增加呈正向关联。 结论： 我国成人尿液乙基对羟基苯甲酸酯暴露与糖尿病患病风险增加之间存在正向关联，女性和烫发染发人群可能是需要重点关注的人群。.