From fragmented records to living evidence: health system-governed, artificial intelligence-driven, continuously updated real-world clinical data from Truveta.

内容摘要

Real-world data (RWD) have historically suffered from fragmentation, delayed availability, variable data quality, and limited analytic utility. Truveta developed an artificial intelligence (AI)-enabled data platform to address these longstanding challenges in using RWD for clinical research. This paper describes Truveta's partnership model, platform design, data scale, and research applications. Truveta de-identifies, aggregates, and harmonizes electronic health record (EHR) data for 130 million patients-1 in 3 Americans-from US health systems. The platform links structured and unstructured EHR content with closed claims, mortality, and social determinants of health. Data undergo daily ingestion, normalization to standard ontologies, and de-identification. Advanced AI, including NLP, extracts key clinical concepts from free-text notes, such as physician notes, imaging reports, and pathology narratives, transforming them into standardized variables suitable for large-scale observational research. Truveta Data comprise over 130 million de-identified patient records that are updated daily and represent diverse geographic regions, care settings, and patient populations in the United States. The data have supported over 100 scientific publications to date; additionally, they support health system participants' own research interests and patient care insights. Published studies have addressed treatment effectiveness, post-market device surveillance, COVID-19 vaccine safety, and health equity. Truveta addresses critical barriers that have hindered the realization of a learning health system. Unlike prior RWD initiatives limited by scope, latency, and vendor dependence, Truveta enables near-real-time, population-scale research grounded in rich clinical data. Its governance model ensures alignment with ethical, privacy, and regulatory standards. By rethinking the role of health systems from passive suppliers into active, incentivized partners, Truveta creates an unprecedented virtuous cycle of data quality and continuous improvement. Truveta represents a paradigm shift in real-world evidence generation. By aligning incentives and AI-driven harmonization, it provides a scalable, sustainable infrastructure for continuously updated clinical data. Providing large-scale, high-fidelity EHR data and daily updates, the platform accelerates clinical discovery, policy and public health decision-making, and improved patient outcomes.