Objective: To investigate the incidence characteristics of occupational contraindications among workers exposed to occupational hazard factors in the Guangzhou area and providing reference data for effective occupational health surveillance. Methods: In March 2024, a cross-sectional study was conducted to collect health examination data from individuals who underwent occupational health examinations at the Guangzhou Occupational Disease Prevention and Treatment Institute between 2021 and 2023. Statistical analysis was performed on the detection rates of occupational contraindications across different genders, ages, examination categories, and occupational hazard factors/special operations. Intergroup comparisons were conducted using t-tests, or analysis of variance (ANOVA), group comparisons were conducted using chisquare (χ(2)) tests. Results: A total of 205938 occupational health examinations were screened, yielding 2883 detected cases of occupational contraindications (detection rate: 1.40%). Among these, 1971 cases (68.37%) were identified during active employment (χ(2)=208.41, P<0.001) ; males accounted for the majority (2673 cases, 92.72%), with no statistically significant gender difference (χ(2)=0.02, P=0.893). The primary exposure hazard factors or special operations included noise exposure (1443 cases, 47.64%), high-temperature work (567 cases, 18.72%), and occupational motor vehicle driving (356 cases, 11.75%). Significant differences in detection rates were observed across years, age groups, and hazard factors/special operations (χ(2)=6.43, 972.62, 2861.94; all P<0.05) . Conclusion: The detection rate of occupational contraindications among workers exposed to occupational hazard factors in the Guangzhou area is relatively low, predominantly affecting young and middle-aged male workers engaged in on-the-job activities. Targeted health surveillance should be intensified for key populations and core hazard factors to mitigate occupational health risks. 目的： 分析广州地区职业病危害接触工人职业禁忌证的发病特征，为有效开展职业健康监护提供参考数据。 方法： 于2024年3月，用横断面研究的方法，收集2021至2023年在广州市职业病防治院完成职业健康体检人员的检查资料，分析不同性别、年龄、体检类别、职业病危害因素/特殊作业的职业禁忌证人员检出情况，组间比较用t检验、方差分析或χ(2)检验。 结果： 共筛选职业健康检查205 938人次，检出职业禁忌证2 883例（检出率1.40%）。在岗期间职业健康检查人员总检出例数为1 971例，占总检出人数的68.37%（χ(2)= 208.41，P<0. 001）；以男性为主（2 673例，占92.72%），但性别差异无统计学意义（χ(2)=0.02，P=0.893）。人员接触的危害因素或特殊作业主要为噪声，高温作业和职业机动车驾驶（分别检出1 443例、567例和356例，各占47.64%、18.72%、11.75%）。不同年份、年龄组、危害因素或特殊作业的职业禁忌证检出率差异有统计学意义（χ(2)=6.43、972.62、2 861.94，均P<0.05）。 结论： 广州地区接触职业病危害因素工人职业禁忌证检出率较低，以青壮年男性在岗作业人员为主。应针对重点人群与核心危害因素加强针对性健康监护，降低职业健康风险。.
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