Objective: To explore the association between urinary nickel levels and impaired renal function in older adults aged ≥65 years from 18 longevity regions of China. Methods: Based on the 2021 China Healthy Ageing and Biomarkers Cohort Study, 5 045 participants were enrolled. Venous blood and urine samples were collected to detect renal function-related indicators and urinary nickel. Impaired renal function was jointly determined by calculating the estimated glomerular filtration rate and urinary albumin-creatinine ratio, and urinary nickel levels were adjusted by urinary creatinine. To assess the relationship between urinary nickel levels and impaired kidney function, we used multivariate logistic regression. Restricted cubic splines were applied to examine the dose-response relationship, with additional subgroup analyses and interaction analyses performed. Results: The median age of participants was 83.40 years, 54.73% of whom were female, and the median urinary nickel level was 2.10 μg/L. Following adjustment for covariates in the multivariate logistic regression analysis, the comparison with the Q1 revealed that the Q4 group of urinary nickel had a 26% increased risk of impaired renal function (OR=1.26, 95%CI: 1.05-1.51). Dose-response analysis revealed a positive nonlinear association between urinary creatinine-adjusted urinary nickel and impaired renal function (all P for overall <0.05, nonlinear P<0.05). Subgroup and interaction analyses indicated that the association between urinary nickel and impaired renal function was more significant in men, Han Chinese, and non-diabetic populations, with significant interaction effects (all P<0.05). Conclusion: The risk of impaired renal function increases with elevated urinary nickel levels in older adults aged ≥65 years from 18 longevity areas of China. 目的： 探讨中国18个长寿地区≥65岁老年人尿镍水平与肾功能受损间的关联。 方法： 基于2021年中国老年健康生物标志物队列研究项目，纳入5 045名研究对象。采集静脉血和尿液检测肾功能相关指标和尿镍。通过计算估算肾小球滤过率和尿白蛋白肌酐比值联合评估肾功能受损，采用尿肌酐校正尿镍水平。采用多因素logistic回归模型探索尿镍水平与肾功能受损风险间的关联，限制性立方样条函数探索二者间的剂量-反应关系，进一步开展亚组分析和交互作用分析。 结果： 研究对象中位年龄为83.40岁，其中54.73%为女性，尿镍中位水平为2.10 μg/L。调整混杂因素后，多因素logistic回归模型结果显示，与尿镍Q1组相比，Q4组老年人肾功能受损的风险升高了26%（OR=1.26，95%CI：1.05~1.51）。剂量-反应关系分析结果显示，尿肌酐校正后的尿镍与肾功能受损呈正向非线性关联（总P<0.05，非线性P<0.05）。亚组分析及交互作用分析发现，尿镍与肾功能受损的关联在男性、汉族和非糖尿病人群更显著且交互作用显著（均P<0.05）。 结论： 中国18个长寿地区≥65岁老年人随着尿镍水平增加老年人肾功能受损的风险升高。.
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arXiv · 2026-04-07
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