[Association between blood selenium level and depressive symptoms in older adults aged 65 years and above in 18 longevity areas in China].

内容摘要

Objective: To investigate the association between blood selenium (Se) level and depressive symptoms among the older adults aged &#x2265;65 years in 18 longevity regions of China. Methods: Based on the 2021 China Healthy Ageing and Biomarkers Cohort Study, 5 278 participants were enrolled. In this study, inductively coupled plasma-mass spectrometry was used to measure blood Se levels, and the Patient Health Questionnaire-9 was used to assess depressive symptoms; a score of &#x2265;10 was defined as indicative of depressive symptoms. Multivariable logistic regression models and restricted cubic spline (RCS) analyses were utilized to examine the association and dose-response relationship between blood Se levels and depressive symptoms. Results: The mean age of participants was (84.15&#xb1;11.28) years old, and 55.2% were female. A total of 332 older adults with depressive symptoms were detected, with a detection rate of 6.3%. Compared with those without depressive symptoms, older adults with depressive symptoms have lower blood Se levels (P<0.001), which are (105.02&#xb1;29.77) &#x3bc;g/L and (112.53&#xb1;31.84) &#x3bc;g/L, respectively. Multivariate logistic regression results showed a negative association between blood Se levels and the risk of depressive symptoms. After adjusting for all covariates, for every 10 &#x3bc;g/L increase in blood Se levels, the risk of depressive symptoms decreased by 5% (OR=0.95, 95%CI: 0.91-0.99). Compared with the Q1, the ORs (95%CIs) of blood Se in Q2, Q3, and Q4 were 0.85 (0.63-1.15), 0.69 (0.49-0.95), and 0.67 (0.47-0.94), respectively. Furthermore, RCS analysis revealed a near-linear negative dose-response relationship between blood Se levels and the risk of depressive symptoms (P for linear =0.055). Conclusion: Blood Se level is significantly associated with decreased risk of depressive symptoms among older adults aged 65 and older in 18 longevity regions of China. &#x76ee;&#x7684;&#xff1a; &#x63a2;&#x8ba8;&#x4e2d;&#x56fd;18&#x4e2a;&#x957f;&#x5bff;&#x5730;&#x533a;&#x2265;65&#x5c81;&#x8001;&#x5e74;&#x4eba;&#x8840;&#x7852;&#x4e0e;&#x6291;&#x90c1;&#x75c7;&#x72b6;&#x7684;&#x5173;&#x8054;&#x3002; &#x65b9;&#x6cd5;&#xff1a; &#x57fa;&#x4e8e;2021&#x5e74;&#x4e2d;&#x56fd;&#x8001;&#x5e74;&#x5065;&#x5eb7;&#x751f;&#x7269;&#x6807;&#x5fd7;&#x7269;&#x961f;&#x5217;&#x7814;&#x7a76;&#x9879;&#x76ee;&#xff0c;&#x5171;&#x7eb3;&#x5165;&#x4e86;5 278&#x540d;&#x7814;&#x7a76;&#x5bf9;&#x8c61;&#x3002;&#x91c7;&#x7528;&#x7535;&#x611f;&#x8026;&#x5408;&#x7b49;&#x79bb;&#x5b50;&#x4f53;&#x8d28;&#x8c31;&#x6cd5;&#x68c0;&#x6d4b;&#x8840;&#x7852;&#x6c34;&#x5e73;&#xff1b;&#x91c7;&#x7528;9&#x9879;&#x60a3;&#x8005;&#x5065;&#x5eb7;&#x95ee;&#x5377;&#x6291;&#x90c1;&#x91cf;&#x8868;&#xff08;PHQ-9&#xff09;&#x8bc4;&#x4f30;&#x6291;&#x90c1;&#x75c7;&#x72b6;&#xff0c;&#x4ee5;PHQ-9&#x8bc4;&#x5206;&#x2265;10&#x5206;&#x5b9a;&#x4e49;&#x4e3a;&#x6709;&#x6291;&#x90c1;&#x75c7;&#x72b6;&#x3002;&#x91c7;&#x7528;&#x591a;&#x56e0;&#x7d20;logistic&#x56de;&#x5f52;&#x6a21;&#x578b;&#x53ca;&#x9650;&#x5236;&#x6027;&#x7acb;&#x65b9;&#x6837;&#x6761;&#xff08;RCS&#xff09;&#x5206;&#x6790;&#x8840;&#x7852;&#x6c34;&#x5e73;&#x4e0e;&#x6291;&#x90c1;&#x75c7;&#x72b6;&#x7684;&#x5173;&#x8054;&#x53ca;&#x5242;&#x91cf;-&#x53cd;&#x5e94;&#x5173;&#x7cfb;&#x3002; &#x7ed3;&#x679c;&#xff1a; &#x7814;&#x7a76;&#x5bf9;&#x8c61;&#x5e74;&#x9f84;&#x4e3a;&#xff08;84.15&#xb1;11.28&#xff09;&#x5c81;&#xff0c;&#x5973;&#x6027;&#x5360;55.2%&#x3002;&#x5171;&#x68c0;&#x51fa;&#x6709;&#x6291;&#x90c1;&#x75c7;&#x72b6;&#x7684;&#x8001;&#x5e74;&#x4eba;332&#x540d;&#xff0c;&#x68c0;&#x51fa;&#x7387;&#x4e3a;6.3%&#x3002;&#x4e0e;&#x65e0;&#x6291;&#x90c1;&#x75c7;&#x72b6;&#x8005;&#x76f8;&#x6bd4;&#xff0c;&#x6709;&#x6291;&#x90c1;&#x75c7;&#x72b6;&#x7684;&#x8001;&#x5e74;&#x4eba;&#x8840;&#x7852;&#x6c34;&#x5e73;&#x66f4;&#x4f4e;&#xff0c;&#x5206;&#x522b;&#x4e3a;&#xff08;105.02&#xb1;29.77&#xff09;&#x3bc;g/L&#x548c;&#xff08;112.53&#xb1;31.84&#xff09;&#x3bc;g/L&#xff08;P<0.001&#xff09;&#x3002;&#x591a;&#x56e0;&#x7d20;logistic&#x56de;&#x5f52;&#x6a21;&#x578b;&#x7ed3;&#x679c;&#x663e;&#x793a;&#xff0c;&#x8840;&#x7852;&#x6c34;&#x5e73;&#x4e0e;&#x6291;&#x90c1;&#x75c7;&#x72b6;&#x98ce;&#x9669;&#x5448;&#x8d1f;&#x5411;&#x5173;&#x8054;&#x3002;&#x5728;&#x8c03;&#x6574;&#x6240;&#x6709;&#x534f;&#x53d8;&#x91cf;&#x540e;&#xff0c;&#x8840;&#x7852;&#x6c34;&#x5e73;&#x6bcf;&#x5347;&#x9ad8;10 &#x3bc;g/L&#xff0c;&#x6291;&#x90c1;&#x75c7;&#x72b6;&#x98ce;&#x9669;&#x964d;&#x4f4e;5%&#xff08;OR=0.95&#xff0c;95%CI&#xff1a;0.91~0.99&#xff09;&#x3002;&#x4e0e;Q1&#x7ec4;&#x76f8;&#x6bd4;&#xff0c;&#x8840;&#x7852;Q2&#x3001;Q3&#x3001;Q4&#x7ec4;&#x7684;OR&#x503c;&#xff08;95%CI&#xff09;&#x5206;&#x522b;&#x4e3a;0.85&#xff08;0.63~1.15&#xff09;&#x3001;0.69&#xff08;0.49~0.95&#xff09;&#x548c;0.67&#xff08;0.47~0.94&#xff09;&#x3002;RCS&#x7ed3;&#x679c;&#x663e;&#x793a;&#x8840;&#x7852;&#x6c34;&#x5e73;&#x4e0e;&#x6291;&#x90c1;&#x75c7;&#x72b6;&#x98ce;&#x9669;&#x4e4b;&#x95f4;&#x5b58;&#x5728;&#x8d8b;&#x4e8e;&#x7ebf;&#x6027;&#x7684;&#x8d1f;&#x5411;&#x5242;&#x91cf;-&#x53cd;&#x5e94;&#x5173;&#x7cfb;&#xff08;&#x7ebf;&#x6027;P=0.055&#xff09;&#x3002; &#x7ed3;&#x8bba;&#xff1a; &#x4e2d;&#x56fd;18&#x4e2a;&#x957f;&#x5bff;&#x5730;&#x533a;&#x2265;65&#x5c81;&#x8001;&#x5e74;&#x4eba;&#x7fa4;&#x8840;&#x7852;&#x6c34;&#x5e73;&#x4e0e;&#x6291;&#x90c1;&#x75c7;&#x72b6;&#x98ce;&#x9669;&#x5448;&#x8d1f;&#x5411;&#x5173;&#x8054;&#x3002;.