Crystal structures of (S)-3-{1-[(4-chloro-phen-yl)sulfon-yl]piperidin-2-yl}pyridine, (S)-3-[1-(4-methyl-phen-yl)piperidin-2-yl]pyridine, (S)-3-{1-[(4-meth-oxy-phen-yl)sulfon-yl]piperidin-2-yl}pyridine and (S)-3-{1-[(3,4-di-methyl-phen-yl)sulfon-yl]piperidin-2-yl}pyridine.

内容摘要

In the presence of tri-methyl-amine, new compounds were obtained by aryl-sulfonyl-ation of 3-(piperidin-2-yl)pyridine (the alkaloid anabasine), namely: (S)-3-{1-[(4-chloro-phen-yl)sulfon-yl]piperidin-2-yl}pyridine, C16H17ClN2O2S (1); (S)-3-[1-(4-methyl-phen-yl)piperidin-2-yl]pyridine, C17H20N2O2S (2); (S)-3-{1-[(4-meth-oxy-phen-yl)sulfon-yl]piperidin-2-yl}pyridine, C17H20N2O3S (3); and (S)-3-{1-[(3,4-di-methyl-phen-yl)sulfon-yl]piperidin-2-yl}pyridine, C18H22N2O2S (4). In the crystal structures, the spatial arrangement of the pyridine and piperidine rings around the Csp 2-C* bond, as well as the orientation of the benzene ring of the aryl-sulfonyl group relative to the anabasine moiety, are analyzed.