To determine the red blood cell life span (RBCS) in female blood donors using a carbon monoxide (CO) breath test and analyze the influencing factors of RBCS. Female blood donors who donated whole blood at Fujian Blood Center from December 2023 to June 2024 were collected, and RBCS was measured using a CO breath test. The donors were grouped by age and body mass index (BMI), and hematological parameters were analyzed to establish 95% confidence interval. The donors were categorized into ferritin decline group and normal ferritin group based on their iron status, and the RBCS difference between the two groups were compared. The correlation between RBCS and iron metabolism indicators was analyzed and followed by linear regression analysis. The distribution of RBCS in 365 female blood donors was skewed. There were no significant differences in RBCS between different age groups and different BMI groups (P >0.05). The 95% confidence interval for RBCS was 67.7-173.2 days. The RBCS of ferritin decline group was 115.1(96.9,133.5) days, which was significantly longer than 107.1(88.5,127.7) days of normal ferritin group (P < 0.05). RBCS was significantly negatively correlated with serum iron and transferrin saturation (r =-0.412, -0.431), and positively correlated with unsaturated iron binding capacity (r =0.348). The multiple linear regression analysis of RBCS indicated that, in addition to hemoglobin and endtidal carbon monoxide, serum iron was also an important factor affecting RBCS (P < 0.05). As the availability of iron decreases, RBCS is prolonged, which may be an early compensatory response to iron deficiency in the body. 女性献血者红细胞寿命的测定及影响因素分析. 通过一氧化碳呼气试验测定女性献血者红细胞寿命（RBCS），并分析RBCS的相关影响因素。. 选取2023年12月-2024年6月在福建省血液中心捐献全血的女性献血者，采用一氧化碳呼气试验测定RBCS，按年龄、体重指数（BMI）进行分组并对各组血液学指标数据进行分析，建立95%置信区间；根据铁储备状况将女性献血者分为铁蛋白下降组和正常组，对比RBCS在两组间的差异性，分析RBCS与铁代谢指标的相关性，并进行线性回归分析。. 365名女性献血者的RBCS呈偏态分布，不同年龄、不同BMI组别之间的RBCS比较，差异均无统计学意义（P >0.05），其95%置信区间为67.7-173.2 d。铁蛋白下降组RBCS为115.1(96.9,133.5)d，明显长于正常组107.1(88.5,127.7)d（P < 0.05）。RBCS与血清铁、转铁蛋白饱和度呈显著负相关（r =-0.412、-0.431），与不饱和铁结合力呈显著正相关（r =0.348）。RBCS的多重线性回归分析显示，除了血红蛋白和呼气末一氧化碳浓度外，血清铁也是影响RBCS的重要因素（P < 0.05）。. 随着铁的可利用性下降，RBCS延长，RBCS延长可能是对机体缺铁的早期代偿性反应。.
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arXiv · 2025-07-07
arXiv · 2025-11-10