Objective: To investigate the current status of post-traumatic growth (PTG) among university students, and to explore its mediation pathway with post-traumatic stress symptoms (PTSS). Methods: This study was a multicenter cross-sectional survey. From December 2024 to January 2025, using convenience sampling, 718 university students aged >18 years who met the inclusion criteria and had experienced stressful life events in the past year were selected from two comprehensive universities and one medical university in Chongqing as the study participants. A self-designed demographic questionnaire was used to collect demographic information of the university students, including gender, age, grade level, and family structure, etc. The adolescent self-rating life events checklist was used to assess university students' experiences of stressful life events and whether they were affected by these events. The post-traumatic stress disorder checklist-civilian version, the Chinese-Posttraumatic Growth Inventory, the 10-item Connor-Davidson resilience scale, and the Chinese PERMA-Profiler were used to assess university students' levels of PTSS, PTG, psychological resilience, and well-being, respectively. University students were classified according to demographic information and whether they were affected by stressful life events, and their total PTG scores were compared. Analysis of the correlation among PTG, PTSS, psychological resilience, and well-being in university students was carried out. Independent influencing factors for PTG among university students were identified. A structural equation model was constructed to analyze the mediating effects of well-being and psychological resilience on the transformation between PTSS and PTG. Results: Totally 718 questionnaires were distributed, and 647 valid questionnaires were returned, with a valid response rate of 90.1%. Among the university students, there were 584 males and 63 females, aged 18 to 27 years. There were 84 first-year students, 178 second-year students, 196 third-year students, and 189 fourth-year students. Among them, 582 students were from two-parent families, and 65 students were from single-parent families. Totally 102 students were affected by stressful life events, while 545 students were not affected by stressful life events. The stressful life events experienced by university students included 27 items, such as physical trauma, acute or serious illness, interpersonal tension, and academic pressure. The total scores of PTSS, PTG, psychological resilience, and well-being among university students were 18.00 (17.00, 27.00), 64.00 (41.00, 80.00), 30.00 (21.00, 39.00), and 118.00 (90.00, 135.00), respectively. Comparisons of total PTG scores among university students showed statistically significant differences by different age, family structure, and exposure to stressful life events (with Z values of -3.426, -2.285, and -3.693, respectively, P<0.05). The total PTG score and its subdimension scores of university students were significantly positively correlated with the total psychological resilience score, the total well-being score and its subdimension scores (with r values of 0.377 to 0.653, P<0.05). Age, family structure, whether being affected by stressful life events, well-being, and psychological resilience were independent influencing factors for PTG among university students (with β values of -0.144, 0.109, -0.151, 0.181, and 0.603, respectively, P<0.05). The constructed model was a multiple mediation model. Between PTSS and PTG transformation, both the independent mediating effect of well-being and the chain-mediating effects of well-being and psychological resilience were statistically significant (with β values of -0.140 and -0.287, respectively, 95% CI of -0.224 to -0.075 and -0.381 to -0.214, respectively, P<0.05), and the chain-mediating effect of well-being and psychological resilience was significantly higher than the independent mediating effect of well-being (β=0.146, with a 95% CI of 0.027 to 0.275, P<0.05). Conclusions: PTG among university students is at a moderate level. Well-being and psychological resilience play a chain-mediating role in the transformation between PTSS and PTG among university students. 目的： 调查大学生创伤后成长（PTG）现状，探讨其与创伤后应激症状（PTSS）之间的中介路径。 方法： 该研究为多中心横断面调查。2024年12月—2025年1月，采用便利抽样法，选取重庆市2所综合大学、1所医科大学中符合入选标准的18岁以上近1年经历生活应激事件的718名在校大学生，作为研究对象。采用自编人口学问卷调查大学生性别、年龄、年级、家庭结构等人口学资料；采用青少年生活事件量表调查大学生生活应激事件经历及是否受这些事件影响；采用创伤后应激障碍自评量表平民版、中文版PTG评定量表、简版心理弹性量表及中文版PERMA幸福指数量表，分别评估大学生PTSS、PTG、心理弹性和幸福感水平。将大学生按人口学资料和是否受生活应激事件影响分类，比较其PTG总评分；分析大学生PTG、PTSS、心理弹性及幸福感之间的相关性；筛选大学生PTG的独立影响因素；通过构建结构方程模型，分析幸福感和心理弹性在PTSS与PTG转化间的中介效应。 结果： 共发放问卷718份，回收有效问卷647份，有效回收率为90.1%。大学生中，男584人、女63人，年龄18~27岁，年级为大一年级者84人、大二年级者178人、大三年级者196人、大四年级者189人，家庭结构为双亲家庭者582人、单亲家庭者65人，受生活应激事件影响者102人、未受生活应激事件影响者545人。大学生经历的生活应激事件包括躯体创伤、患急重病、人际关系紧张、学习压力大等27项。大学生PTSS、PTG、心理弹性和幸福感总评分分别为18.00（17.00，27.00）、64.00（41.00，80.00）、30.00（21.00，39.00）、118.00（90.00，135.00）分。不同年龄、家庭结构、生活应激事件影响大学生PTG总评分比较，差异均有统计学意义（Z值分别为-3.426、-2.285、-3.693，P<0.05）。大学生PTG总评分及其各维度评分与心理弹性总评分、幸福感总评分及其各维度评分均呈显著正相关（r值为0.377~0.653，P<0.05）。年龄、家庭结构、是否受应激事件影响、幸福感和心理弹性均是大学生PTG的独立影响因素（β值分别为-0.144、0.109、-0.151、0.181、0.603，P<0.05）。构建的模型为多重中介模型，在PTSS与PTG转化间，幸福感的单独中介效应及幸福感与心理弹性的链式中介效应均具有统计学意义（β值分别为-0.140、-0.287，95%CI分别为-0.224~-0.075、-0.381~-0.214，P<0.05），幸福感与心理弹性的链式中介效应显著高于幸福感的单独中介效应（β=0.146，95%CI为0.027~0.275，P<0.05）。 结论： 大学生PTG呈中等水平，幸福感和心理弹性在大学生PTSS与PTG转化间发挥链式中介作用。.
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