[Research Advances in Obstructive Sleep Apnea and Lung Cancer Comorbidity].

内容摘要

Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder characterized by recurrent upper airway collapse and apnea during sleep, resulting in intermittent hypoxia, oxidative stress, and systemic inflammation, and is closely associated with multisystem dysfunction, including cardiovascular disease, cognitive impairment, and metabolic abnormalities. Lung cancer remains one of the leading causes of cancer-related mortality worldwide and represents a major threat to human health. Recent studies suggest that OSA and lung cancer share several common risk factors, including smoking, older age, and obesity, and exhibit overlapping pathophysiological mechanisms, indicating that OSA may be involved in the initiation and progression of lung cancer. However, the epidemiological evidence regarding the association between OSA and lung cancer remains inconsistent, and the underlying molecular mechanisms as well as the clinical value of potential interventions have yet to be systematically elucidated. This review therefore summarizes the epidemiological characteristics, potential pathophysiological mechanisms, and therapeutic strategies related to the coexistence of OSA and lung cancer, with the aim of providing a theoretical basis for clinical decision-making and future mechanistic studies.
. 【中文题目：阻塞性睡眠呼吸暂停合并肺癌的研究进展】 【中文摘要：阻塞性睡眠呼吸暂停（obstructive sleep apnea, OSA）是临床常见的睡眠障碍性疾病，其典型特征为睡眠过程中反复发生的上气道塌陷与呼吸暂停现象，可引起间歇性低氧、氧化应激及全身炎症反应，并与心血管疾病、认知功能障碍及代谢异常等多系统功能损害密切相关。肺癌作为全球肿瘤相关死亡的主要原因之一，严重威胁患者的生命健康。近年来研究发现OSA与肺癌具有吸烟、高龄及肥胖等共同危险因素，且二者在病理生理机制上存在一定交叉性，提示OSA可能参与肺癌的发生发展过程。然而，目前关于OSA合并肺癌的流行病学证据仍不一致，其潜在分子机制及临床干预价值尚未得到系统阐明，相关研究仍存在一定不足。故本文拟从OSA合并肺癌的流行病学现状、可能的病理生理机制以及治疗策略等方面进行综述，以期为后续临床治疗决策以及机制研究提供理论依据及参考。
】 【中文关键词：阻塞性睡眠呼吸暂停；肺肿瘤；慢性间歇性低氧；病理生理机制；流行病学】.