[Investigation on the incidence of pertussis and the carriage and distribution characteristics of Bordetella pertussis among healthy individuals in certain regions of Xinjiang Uygur Autonomous Region from 2023 to 2024].

内容摘要

Objective: To analyze the incidence of pertussis and the carriage and distribution characteristics of Bordetella pertussis (BP) among healthy individuals in certain regions of Xinjiang during 2023-2024, providing scientific evidence for the prevention and control of pertussis. Methods: Patients' information in Urumqi, Karamay and Ili governorates from 2023 to 2024 was collected in the Chinese Disease Control and Prevention Information System, and the incidence of pertussis was analyzed. A multi-stage sampling method was used to select 1-2 districts (counties) as survey points in each of the above regions from June to July 2023 and October to November 2024. Nasopharyngeal swabs from healthy individuals were collected, and their BP-carrying status was analyzed through on-site vaccination, bacterial culture, and polymerase chain reaction experiments. Results: From 2023 to 2024, Karamay had a high incidence of pertussis, with a rate of 140.53/100 000. The incidence rate of pertussis declined with age (&#x3c7;2=4 327.14, P<0.001), with the highest incidence rate in the 0-4 year age group (269.02/100 000) and the lowest in the &#x2265;20-year age group (3.37/100 000). A total of 971 nasopharyngeal swab samples were collected from healthy individuals, with a BP carrier positivity rate of 1.54% (15/971). The BP carrier positivity rate was higher in the &#x2265;20-year age group, at 2.42% (4/165). Conclusion: Confirmed cases of pertussis in some areas of Xinjiang in 2023-2024 are highly prevalent in the 0-4 year age group, with a higher positive rate of BP carriers among healthy individuals aged &#x2265;20, suggesting that adults may be a hidden source of pertussis transmission. Attention should be paid to the management of pertussis in children, while strengthening monitoring of adults. &#x76ee;&#x7684;&#xff1a; &#x5206;&#x6790;&#x65b0;&#x7586;&#x90e8;&#x5206;&#x5730;&#x533a;2023&#x2014;2024&#x5e74;&#x767e;&#x65e5;&#x54b3;&#x53d1;&#x75c5;&#x60c5;&#x51b5;&#x548c;&#x5065;&#x5eb7;&#x4eba;&#x7fa4;&#x4e2d;&#x767e;&#x65e5;&#x54b3;&#x9c8d;&#x7279;&#x6746;&#x83cc;&#xff08;BP&#xff09;&#x7684;&#x643a;&#x5e26;&#x72b6;&#x51b5;&#xff0c;&#x4e3a;&#x767e;&#x65e5;&#x54b3;&#x9632;&#x63a7;&#x63d0;&#x4f9b;&#x53c2;&#x8003;&#x3002; &#x65b9;&#x6cd5;&#xff1a; &#x5728;&#x4e2d;&#x56fd;&#x75be;&#x75c5;&#x9884;&#x9632;&#x63a7;&#x5236;&#x4fe1;&#x606f;&#x7cfb;&#x7edf;&#x6536;&#x96c6;2023&#x2014;2024&#x5e74;&#x4e4c;&#x9c81;&#x6728;&#x9f50;&#x5e02;&#x3001;&#x514b;&#x62c9;&#x739b;&#x4f9d;&#x5e02;&#x548c;&#x4f0a;&#x7281;&#x5dde;&#x767e;&#x65e5;&#x54b3;&#x60a3;&#x8005;&#x4fe1;&#x606f;&#xff0c;&#x5206;&#x6790;&#x767e;&#x65e5;&#x54b3;&#x53d1;&#x75c5;&#x60c5;&#x51b5;&#x3002;&#x91c7;&#x7528;&#x591a;&#x9636;&#x6bb5;&#x62bd;&#x6837;&#x6cd5;&#xff0c;&#x4e8e;2023&#x5e74;6&#x81f3;7&#x6708;&#x548c;2024&#x5e74;10&#x81f3;11&#x6708;&#xff0c;&#x5728;&#x4ee5;&#x4e0a;&#x5730;&#x533a;&#x5404;&#x9009;&#x53d6;1~2&#x4e2a;&#x533a;&#xff08;&#x53bf;&#xff09;&#x4f5c;&#x4e3a;&#x8c03;&#x67e5;&#x70b9;&#xff0c;&#x91c7;&#x96c6;&#x5065;&#x5eb7;&#x4eba;&#x7fa4;&#x7684;&#x9f3b;&#x54bd;&#x62ed;&#x5b50;&#xff0c;&#x901a;&#x8fc7;&#x73b0;&#x573a;&#x63a5;&#x79cd;&#x3001;&#x7ec6;&#x83cc;&#x57f9;&#x517b;&#x548c;&#x805a;&#x5408;&#x9176;&#x94fe;&#x53cd;&#x5e94;&#x5b9e;&#x9a8c;&#x68c0;&#x6d4b;&#xff0c;&#x5206;&#x6790;&#x5065;&#x5eb7;&#x4eba;&#x7fa4;BP&#x643a;&#x5e26;&#x72b6;&#x51b5;&#x3002; &#x7ed3;&#x679c;&#xff1a; 2023&#x2014;2024&#x5e74;&#x514b;&#x62c9;&#x739b;&#x4f9d;&#x5e02;&#x767e;&#x65e5;&#x54b3;&#x53d1;&#x75c5;&#x7387;&#x8f83;&#x9ad8;&#xff0c;&#x4e3a;140.53/10&#x4e07;&#xff1b;&#x767e;&#x65e5;&#x54b3;&#x53d1;&#x75c5;&#x7387;&#x968f;&#x5e74;&#x9f84;&#x589e;&#x957f;&#x5448;&#x4e0b;&#x964d;&#x8d8b;&#x52bf;&#xff08;&#x3c7;&#xb2;=4 327.14&#xff0c;P<0.001&#xff09;&#xff0c;0~4&#x5c81;&#x7ec4;&#x53d1;&#x75c5;&#x7387;&#x6700;&#x9ad8;&#xff08;269.02/10&#x4e07;&#xff09;&#xff0c;&#x2265;20&#x5c81;&#x7ec4;&#x6700;&#x4f4e;&#xff08;3.37/10&#x4e07;&#xff09;&#x3002;&#x91c7;&#x96c6;&#x5230;&#x5065;&#x5eb7;&#x4eba;&#x7fa4;&#x9f3b;&#x54bd;&#x62ed;&#x5b50;&#x6807;&#x672c;971&#x4efd;&#xff0c;BP&#x643a;&#x5e26;&#x9633;&#x6027;&#x7387;&#x4e3a;1.54%&#xff08;15/971&#xff09;&#xff0c;&#x2265;20&#x5c81;&#x6210;&#x4eba;&#x7ec4;&#x7684;BP&#x643a;&#x5e26;&#x9633;&#x6027;&#x7387;&#x8f83;&#x9ad8;&#x4e3a;2.42%&#xff08;4/165&#xff09;&#x3002; &#x7ed3;&#x8bba;&#xff1a; 2023&#x2014;2024&#x5e74;&#x65b0;&#x7586;&#x90e8;&#x5206;&#x5730;&#x533a;&#x767e;&#x65e5;&#x54b3;&#x786e;&#x8bca;&#x75c5;&#x4f8b;&#x4ee5;0~4&#x5c81;&#x5e74;&#x9f84;&#x7ec4;&#x4e3a;&#x9ad8;&#x53d1;&#xff0c;&#x2265;20&#x5c81;&#x7ec4;&#x5065;&#x5eb7;&#x4eba;&#x7fa4;BP&#x643a;&#x5e26;&#x9633;&#x6027;&#x7387;&#x8f83;&#x9ad8;&#xff0c;&#x63d0;&#x793a;&#x6210;&#x4eba;&#x53ef;&#x80fd;&#x662f;&#x767e;&#x65e5;&#x54b3;&#x4f20;&#x64ad;&#x7684;&#x9690;&#x533f;&#x4f20;&#x67d3;&#x6e90;&#xff0c;&#x5e94;&#x5173;&#x6ce8;&#x767e;&#x65e5;&#x54b3;&#x513f;&#x7ae5;&#x60a3;&#x8005;&#x7684;&#x7ba1;&#x7406;&#xff0c;&#x540c;&#x65f6;&#x52a0;&#x5f3a;&#x5bf9;&#x6210;&#x4eba;&#x7684;&#x76d1;&#x6d4b;&#x3002;.