Objective To investigate the association between Epstein-Barr virus(EBV)and nasopharyngeal carcinoma(NPC)and to evaluate the roles of EBV antibodies Rta-IgG,VCA-IgA,and EA-IgA in the screening of NPC. Methods The related literature was retrieved from the Web of Science Core Collection.The publication output,keyword co-occurrence,and country/region collaboration were analyzed with VOSviewer,CiteSpace,and Excel.A total of 402 NPC patients,915 individuals with nasal symptoms,and 27 395 healthy participants undergoing physical examination in Xiangya Hospital,The Second Xiangya Hospital,and The Third Xiangya Hospital were enrolled.Serum Rta-IgG,VCA-IgA,and EA-IgA levels were measured by ELISA,and their diagnostic performance for NPC was assessed by receiver operating characteristic curves.Inter-group differences were compared through the χ2 test. Results The research on EBV-NPC was highly productive.The top three keywords by frequency were nasopharyngeal carcinoma,Epstein-Barr virus,and cancer.China was the leading contributor.In the NPC cohort,the diagnostic sensitivities of Rta-IgG,VCA-IgA,and EA-IgA were 76.12%,83.58%,and 62.19%,respectively,which were higher than those in the other two groups(all P<0.001).VCA-IgA showed the highest sensitivity(83.58%),whereas EA-IgA exhibited the best specificity(97.41%).The three antibodies showed high negative prediction values,which were 99.65%,99.76%,and 99.45%.Combined testing of Rta-IgG,VCA-IgA,and EA-IgA increased the sensitivity to 99.50%. Conclusions The EBV-NPC link remains a major research focus.Serum Rta-IgG,VCA-IgA,and EA-IgA levels are clinically valuable for NPC diagnosis,and their combined detection significantly improves the screening efficiency. 目的 研究EB病毒(EBV)与鼻咽癌(NPC)的相关性及EBV Rta蛋白IgG抗体(Rta-IgG)、衣壳抗原IgA抗体(VCA-IgA)和早期抗原IgA抗体(EA-IgA)在NPC筛查中的作用。 方法 通过Web of Science Core Collection数据库检索文献,采用VOSviewer、CiteSpace和Excel分析发文量、关键词共现及国家/地区共现。选取湘雅医院、湘雅二医院和湘雅三医院的402例NPC患者、915例有鼻部症状患者和27 395例健康体检者,采用ELISA法检测3组受试者血清中的Rta-IgG、VCA-IgA和EA-IgA,分析其在NPC筛查中的效能,并用卡方检验比较组间差异,受试者工作特征曲线评价诊断效能。 结果 EBV与NPC研究发文量高,出现频次前三的关键词是nasopharyngeal carcinoma、estein-barr virus和cancer,中国是核心研究国家。NPC组Rta-IgG、VCA-IgA和EA-IgA的诊断灵敏度分别为76.12%、83.58%和62.19%,显著高于其他两组(P均<0.001)。VCA-IgA灵敏度最高(83.58%),EA-IgA特异度最好(97.41%);3种抗体的阴性预测值均较高,分别为99.65%、99.76%和99.45%;联合检测Rta-IgG、VCA-IgA和EA-IgA可提高NPC诊断灵敏度至99.50%。 结论 EBV和NPC的联系是研究热点之一。NPC患者血清Rta-IgG、VCA-IgA、EA-IgA抗体具临床诊断价值,联合检测可提高NPC筛查效率。.
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PubMed · 2026-04-01
PubMed · 2026-04-01
PubMed · 2026-04-01