Potential of IMNN-001 in epithelial ovarian cancer: assessment of clinical findings.

内容摘要

IMNN-001 is designed for local and durable delivery of a pluripotent anti-tumor cytokine, IL-12, using an expression plasmid and a synthetic lipopolymer delivery system. IMNN-001, delivered intraperitoneally in combination with chemotherapy, is currently in a Phase 3 trial for the front-line treatment of advanced epithelial ovarian cancer. This report details IMNN-001 preclinical and clinical development, demonstrating local and durable production of IL-12, minimal systemic exposure and manageable safety profile, as well as its antitumoral effects in a total of six completed trials in ovarian cancer. In the OVATION-2 Phase 2 randomized trial, neo- and adjuvant chemotherapy combined with IMNN-001 produced a numerical 13 month increase in overall survival, with even greater benefit in tumors that lacked DNA homologous repair activity. In translational studies, IMNN-001-induced changes in the tumor microenvironment are consistent with the observed induction of IL-12 and IFN-γ levels at the tumor site and support the hypothesis that IMNN-001 treatment alters the tumor microenvironment in favor of broad immune stimulation and inhibition of immunosuppressive mechanisms. IMNN-001 gene therapy could add clinically meaningful IL-12-driven immunotherapy to newly diagnosed ovarian cancer patients. IMNN-001 holds promise for synergistic combinations with immunotherapies requiring intrinsic immune activity. The recent ability to harness a patient’s own immune system to control or destroy a tumor has revolutionized the care and outcomes in many types of cancers. Unfortunately, up to this time, such efforts have been unsuccessful in ovarian cancer, where the standard of care has not improved for 25 or more years. The barrier in ovarian cancer is that the tumor is not recognized by the body’s defense mechanism. IMNN-001 represents a new and promising approach to this problem. IMNN-001 is designed to stimulate tumor cells and the cells surrounding the tumor to make IL-12, a natural molecule which strongly activates the body’s natural response against the tumor, resulting in the destruction of the malignant cells. In previous and ongoing studies, beneficial outcomes of IMNN-001 on tumor response and survival have been observed with a manageable safety profile. A large clinical trial is ongoing, with the hope that IMNN-001 could provide a new, safe, and novel treatment for women with advanced ovarian cancer.